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Article

Surgical lung biopsy in onco‑hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU

  • Authors:
    • Eduardo Mantovani Cardoso
    • Alexandre Galvão Bueno
    • Daniel Augusto Pavan
    • Ademar Dantas Cunha
    • Raysa Cristina Schmidt
    • Péricles A.D. Duarte
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, Hospital do Câncer/UOPECCAN, Cascavel, Paraná 85806‑300, Brazil, Department of Pathology, Hospital do Câncer/UOPECCAN, Cascavel, Paraná 85806‑300, Brazil, Department of Thoracic Surgery, Hospital do Câncer/UOPECCAN, Cascavel, Paraná 85806‑300, Brazil, Department of Oncology, Hospital do Câncer/UOPECCAN, Cascavel, Paraná 85806‑300, Brazil
  • Pages: 3997-4003
    |
    Published online on: February 21, 2019
       https://doi.org/10.3892/ol.2019.10065
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Abstract

Among onco‑hematological patients with acute respiratory failure (ARpF), surgical lung biopsy (SLB) could contribute to the medical management, by guiding initiation, maintenance or discontinuation of diagnostic and therapeutic interventions. The aim of the present study was to evaluate the results of SLB in these patients in an oncological center from a medium‑income country, as well as analyze if this procedure is clinically useful in this context, and its impact on complications and mortality. This observational retrospective study analyzed onco‑hematological patients with ARpF in the Intensive Care Unit (ICU) of a cancer center in southern Brazil between 2010‑2016, who required mechanical ventilation and were submitted to open SLB. Among the studied population (n=17), the most commonly found etiology was infectious, present in ~50% of the biopsies, followed by unspecific inflammatory infiltrate acute respiratory distress syndrome and interstitial fibrosis, alveolar hemorrhage, neoplastic infiltrate and pulmonary embolism. Biopsy has led to a change of management in 63.3% of patients that were alive when results were available; however, 35% of patients succumbed prior to the pathological result. There was no requirement for re‑operation or mortality attributable to the procedure. However, ICU mortality was elevated (88%). SLB in onco‑hematological patients mechanically ventilated in the ICU is a safe procedure with few severe complications and that contributes for diagnosis and management in the majority of cases. Due to the high mortality of this population, controlled trials may be required to establish its benefit in mortality and ICU outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Cardoso EM, Bueno AG, Pavan DA, Cunha AD, Schmidt RC and Duarte PA: Surgical lung biopsy in onco‑hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU. Oncol Lett 17: 3997-4003, 2019.
APA
Cardoso, E.M., Bueno, A.G., Pavan, D.A., Cunha, A.D., Schmidt, R.C., & Duarte, P.A. (2019). Surgical lung biopsy in onco‑hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU. Oncology Letters, 17, 3997-4003. https://doi.org/10.3892/ol.2019.10065
MLA
Cardoso, E. M., Bueno, A. G., Pavan, D. A., Cunha, A. D., Schmidt, R. C., Duarte, P. A."Surgical lung biopsy in onco‑hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU". Oncology Letters 17.4 (2019): 3997-4003.
Chicago
Cardoso, E. M., Bueno, A. G., Pavan, D. A., Cunha, A. D., Schmidt, R. C., Duarte, P. A."Surgical lung biopsy in onco‑hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU". Oncology Letters 17, no. 4 (2019): 3997-4003. https://doi.org/10.3892/ol.2019.10065
Copy and paste a formatted citation
x
Spandidos Publications style
Cardoso EM, Bueno AG, Pavan DA, Cunha AD, Schmidt RC and Duarte PA: Surgical lung biopsy in onco‑hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU. Oncol Lett 17: 3997-4003, 2019.
APA
Cardoso, E.M., Bueno, A.G., Pavan, D.A., Cunha, A.D., Schmidt, R.C., & Duarte, P.A. (2019). Surgical lung biopsy in onco‑hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU. Oncology Letters, 17, 3997-4003. https://doi.org/10.3892/ol.2019.10065
MLA
Cardoso, E. M., Bueno, A. G., Pavan, D. A., Cunha, A. D., Schmidt, R. C., Duarte, P. A."Surgical lung biopsy in onco‑hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU". Oncology Letters 17.4 (2019): 3997-4003.
Chicago
Cardoso, E. M., Bueno, A. G., Pavan, D. A., Cunha, A. D., Schmidt, R. C., Duarte, P. A."Surgical lung biopsy in onco‑hematological patients with diffuse pulmonary infiltrates and mechanical ventilation in the ICU". Oncology Letters 17, no. 4 (2019): 3997-4003. https://doi.org/10.3892/ol.2019.10065
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