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Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function

  • Authors:
    • Xiaomin Zhang
    • Hao Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesia, The Second Cancer Hospital of Heilongjiang Province, Harbin, Heilongjiang 150086, P.R. China, Department of Anesthesia, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4443-4448
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    Published online on: February 26, 2019
       https://doi.org/10.3892/ol.2019.10074
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Abstract

Effect of sevoflurane inhalation combined with epidural anesthesia on postoperative perceptual function in patients with colorectal cancer (CRC) was investigated. The clinical data of 78 patients undergoing laparoscopic CRC radical surgery in The Second Cancer Hospital of Heilongjiang Province from June 2016 to June 2017 were retrospectively analyzed and divided into 2 groups: Sevoflurane inhalation combined with epidural anesthesia (observation group, n=40); propofol intravenous general anesthesia (control group, n=38). The mean arterial pressure and heart rate before anesthesia (T0), immediate intubation (T1), 30 min after surgery started (T2), end of surgery (T3), 10 min after extubation (T4) were compared between the two groups. The recovery conditions were also compared between the two groups. The cognitive functions were evaluated by mini-mental state scale (MMSE). The mean arterial pressure and heart rate in the observation group were significantly lower than those in the control group at T2, T3 and T4 (P<0.05). The recovery time, extubation time, anal exhaust time, eating time, urinary catheter removal time and hospital stay in the observation group were significantly lower than those in the control group (P<0.05). There was a significant difference in cognitive function between the two groups at different time points (P<0.001). Postoperative cognitive function showed a trend of decreasing first and then increasing; the scores of cognitive function in both groups 1 day after surgery were at trough level, and recovered gradually from 3 days after surgery. The mean arterial pressure and heart rate during the perioperative period are more stable in the elderly patients with sevoflurane inhalation combined with epidural anesthesia; the recovery time is shorter and more rapid, and the recovery time of postoperative cognitive function is also faster. Therefore, it provides a reference for patients undergoing CRC radical surgery to select high-quality and appropriate anesthetic protocols.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang X and Jiang H: Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function. Oncol Lett 17: 4443-4448, 2019.
APA
Zhang, X., & Jiang, H. (2019). Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function. Oncology Letters, 17, 4443-4448. https://doi.org/10.3892/ol.2019.10074
MLA
Zhang, X., Jiang, H."Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function". Oncology Letters 17.5 (2019): 4443-4448.
Chicago
Zhang, X., Jiang, H."Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function". Oncology Letters 17, no. 5 (2019): 4443-4448. https://doi.org/10.3892/ol.2019.10074
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X and Jiang H: Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function. Oncol Lett 17: 4443-4448, 2019.
APA
Zhang, X., & Jiang, H. (2019). Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function. Oncology Letters, 17, 4443-4448. https://doi.org/10.3892/ol.2019.10074
MLA
Zhang, X., Jiang, H."Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function". Oncology Letters 17.5 (2019): 4443-4448.
Chicago
Zhang, X., Jiang, H."Application of sevoflurane inhalation combined with epidural anesthesia in patients with colorectal cancer and its effect on postoperative perceptual function". Oncology Letters 17, no. 5 (2019): 4443-4448. https://doi.org/10.3892/ol.2019.10074
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