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Article

Upregulated forkhead‑box A3 elevates the expression of forkhead‑box A1 and forkhead‑box A2 to promote metastasis in esophageal cancer

  • Authors:
    • Bing Chen
    • Jiegen Yu
    • Linming Lu
    • Fangyuan Dong
    • Fangfang Zhou
    • Xiangxiang Tao
    • Entao Sun
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medical Sciences, Wannan Medical College, Wuhu, Anhui 241002, P.R. China, Department of Management Science, School of Humanities and Management, Wannan Medical College, Wuhu, Anhui 241002, P.R. China, Department of Health Inspection and Quarantine, School of Laboratory Medicine, Wannan Medical College, Wuhu, Anhui 241002, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4351-4360
    |
    Published online on: February 26, 2019
       https://doi.org/10.3892/ol.2019.10078
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Abstract

Esophageal cancer (EC) is one of the most lethal cancers currently known. Members of the forkhead‑box A (FOXA) family, including FOXA1 and FOXA2, have been reported to regulate EC progression. However, the role of FOXA3, which is another FOXA member, has not yet been investigated. In the present study, public dataset analyses and immunohistochemistry of 96 samples from patients with EC were performed to determine the potential roles of FOXA3 in EC. The results revealed that FOXA3 was significantly upregulated in EC tumor tissues and Barrett's esophagus tissues. In addition, FOXA3 upregulation was positively associated with tumor invasion, distant metastasis, tumor‑node‑metastasis stage and shorter overall survival in patients with EC, and multivariate analysis identified FOXA3 as an independent prognostic marker. In vitro experiments demonstrated that the migratory and invasive abilities of EC109 and EC9706 cell lines were inhibited following FOXA3 knockdown. Notably, FOXA3 expression levels were positively correlated with FOXA1 and FOXA2 expression levels according to The Cancer Genome Atlas dataset analysis. Furthermore, FOXA3 knockdown decreased the expression levels of FOXA1 and FOXA2 in EC109 and EC9706 cell lines. Conversely, FOXA1 or FOXA2 overexpression compensated for the effects of FOXA3 knockdown on the migratory and invasive capacities of EC cells. In conclusion, the present study demonstrated that FOXA3 upregulation in EC cells promoted metastasis through regulation of other FOXA members.
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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Yu J, Lu L, Dong F, Zhou F, Tao X and Sun E: Upregulated forkhead‑box A3 elevates the expression of forkhead‑box A1 and forkhead‑box A2 to promote metastasis in esophageal cancer. Oncol Lett 17: 4351-4360, 2019.
APA
Chen, B., Yu, J., Lu, L., Dong, F., Zhou, F., Tao, X., & Sun, E. (2019). Upregulated forkhead‑box A3 elevates the expression of forkhead‑box A1 and forkhead‑box A2 to promote metastasis in esophageal cancer. Oncology Letters, 17, 4351-4360. https://doi.org/10.3892/ol.2019.10078
MLA
Chen, B., Yu, J., Lu, L., Dong, F., Zhou, F., Tao, X., Sun, E."Upregulated forkhead‑box A3 elevates the expression of forkhead‑box A1 and forkhead‑box A2 to promote metastasis in esophageal cancer". Oncology Letters 17.5 (2019): 4351-4360.
Chicago
Chen, B., Yu, J., Lu, L., Dong, F., Zhou, F., Tao, X., Sun, E."Upregulated forkhead‑box A3 elevates the expression of forkhead‑box A1 and forkhead‑box A2 to promote metastasis in esophageal cancer". Oncology Letters 17, no. 5 (2019): 4351-4360. https://doi.org/10.3892/ol.2019.10078
Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Yu J, Lu L, Dong F, Zhou F, Tao X and Sun E: Upregulated forkhead‑box A3 elevates the expression of forkhead‑box A1 and forkhead‑box A2 to promote metastasis in esophageal cancer. Oncol Lett 17: 4351-4360, 2019.
APA
Chen, B., Yu, J., Lu, L., Dong, F., Zhou, F., Tao, X., & Sun, E. (2019). Upregulated forkhead‑box A3 elevates the expression of forkhead‑box A1 and forkhead‑box A2 to promote metastasis in esophageal cancer. Oncology Letters, 17, 4351-4360. https://doi.org/10.3892/ol.2019.10078
MLA
Chen, B., Yu, J., Lu, L., Dong, F., Zhou, F., Tao, X., Sun, E."Upregulated forkhead‑box A3 elevates the expression of forkhead‑box A1 and forkhead‑box A2 to promote metastasis in esophageal cancer". Oncology Letters 17.5 (2019): 4351-4360.
Chicago
Chen, B., Yu, J., Lu, L., Dong, F., Zhou, F., Tao, X., Sun, E."Upregulated forkhead‑box A3 elevates the expression of forkhead‑box A1 and forkhead‑box A2 to promote metastasis in esophageal cancer". Oncology Letters 17, no. 5 (2019): 4351-4360. https://doi.org/10.3892/ol.2019.10078
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