Non-invasive imaging techniques for the in vivo diagnosis of Bowen's disease: Three case reports

Ianoși,Simona   Laura; Batani,Alexandra; Ilie,Mihaela   Adriana; Tampa,Mircea; Georgescu,Simona-Roxana; Zurac,Sabina; Boda,Daniel; Ianosi,Nicolae   Gabriel; Neagoe,Daniela; Calina,Daniela; Tutunaru,Cristina; Constantin,Caruntu

doi:10.3892/ol.2019.10079

Non-invasive imaging techniques for the in vivo diagnosis of Bowen's disease: Three case reports

Authors:
- Simona Laura Ianoși
- Alexandra Batani
- Mihaela Adriana Ilie
- Mircea Tampa
- Simona-Roxana Georgescu
- Sabina Zurac
- Daniel Boda
- Nicolae Gabriel Ianosi
- Daniela Neagoe
- Daniela Calina
- Cristina Tutunaru
- Caruntu Constantin
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Affiliations: Department of Dermatology, University of Medicine and Pharmacy of Craiova, Emergency County Hospital, 200349 Craiova, Romania, Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, Romania, Dermatology Research Laboratory, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania , Department of Pathology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Surgery, University of Medicine and Pharmacy, 200349 Craiova, Romania, Department of Internal Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania, Department of Pharmacology, University of Medicine and Pharmacy, 200349 Craiova, Romania, Department of Dermatology, ‘Prof. N. Paulescu’ National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania
Published online on: February 27, 2019 https://doi.org/10.3892/ol.2019.10079
Pages: 4094-4101
Copyright: © Ianoși et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bowen's disease (BD) is a relatively frequent non-melanoma skin cancer occurring mostly in elderly people. Until now, the usual way to establish the diagnosis is histopathological examination of a skin biopsy. Dermoscopy and reflectance confocal microscopy (RCM) are modern alternative methods that can be used as quick and non-invasive diagnostic techniques and as follow-up instruments in cases in which a conservative treatment is chosen for the management of BD. There are no very specific dermoscopic criteria for the diagnosis of this disease, but some dermoscopic features (scaly surface, vascular structures and pigmentation) can be found more frequent and can be helpful for the diagnosis. RCM of BD shows an acanthotic epidermis with two types of targetoid cells: the first, a large cell with bright center and dark peripheral halo, the second, a cell with dark center and a bright rim surrounded by a dark hallo, related with dyskeratotic cells on histological examination. BD management could be improved by using non-invasive, in vivo imaging techniques that allow a fast and easy diagnosis and can be used as follow-up tools. However, larger studies are necessary for the validation of our observations.

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