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Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo

  • Authors:
    • Qingan Yu
    • Wenjing Jiang
    • Dan Li
    • Mingqi Gu
    • Kunpeng Liu
    • Liqian Dong
    • Chaoqun Wang
    • Hongchi Jiang
    • Wenjie Dai
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4255-4262
    |
    Published online on: February 28, 2019
       https://doi.org/10.3892/ol.2019.10090
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Abstract

Vanadium and its compounds exhibit concentration‑ and time‑dependent anticancer effects on various types of tumor; however, the effects of sodium orthovanadate (SOV) on anaplastic thyroid carcinoma (ATC) have not yet been reported. In the present study, the anticancer effects of SOV on ATC were evaluated. In vitro experiments, including cell viability assays, plate colony formation assays, cell cycle analysis and apoptosis analysis were used to study the role of SOV in ATC. Using in vivo experiments, the effects of SOV on the growth and apoptosis of an ATC‑xenograft tumor were studied by comparing the SOV‑treatment with the control group. The results revealed that treatment of the human ATC cell line 8505C with SOV inhibited cell viability, induced G2/M phase cell cycle arrest, stimulated apoptosis and reduced mitochondrial membrane potential in a concentration‑dependent manner. These findings were confirmed in vivo in a nude mouse ATC xenograft model. In conclusion, the present study demonstrated that SOV inhibited human ATC by regulating proliferation, cell cycle progression and apoptosis, thus suggesting that SOV may be considered a novel option for the treatment of ATC.
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1 

Nagaiah G, Hossain A, Mooney CJ, Parmentier J and Remick SC: Anaplastic thyroid cancer: A review of epidemiology, pathogenesis, and treatment. J Oncol. 2011:5423582011. View Article : Google Scholar : PubMed/NCBI

2 

Davies L and Welch HG: Increasing incidence of thyroid cancer in the United States, 1973–2002. Jama. 295:2164–2167. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Cornett WR, Sharma AK, Day TA, Richardson MS, Hoda RS, van Heerden JA and Fernandes JK: Anaplastic thyroid carcinoma: An overview. Curr Oncol Rep. 9:152–158. 2007. View Article : Google Scholar : PubMed/NCBI

4 

O'Neill JP, O'Neill B, Condron C, Walsh M and Bouchier-Hayes D: Anaplastic (undifferentiated) thyroid cancer: Improved insight and therapeutic strategy into a highly aggressive disease. J Laryngol Otol. 119:585–591. 2005.PubMed/NCBI

5 

Paunovic IR, Sipetic SB, Zoric GV, Diklic AD, Savic DV, Marinkovic J and Zivaljevic VR: Survival and prognostic factors of anaplastic thyroid carcinoma. Acta Chir Belg. 115:62–72. 2015. View Article : Google Scholar

6 

Perri F, Lorenzo GD, Scarpati GD and Buonerba C: Anaplastic thyroid carcinoma: A comprehensive review of current and future therapeutic options. World J Clin Oncol. 2:150–157. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Kim SH, Kang JG, Kim CS, Ihm SH, Choi MG, Yoo HJ and Lee SJ: Apigenin induces c-Myc-mediated apoptosis in FRO anaplastic thyroid carcinoma cells. Mol Cell Endocrinol. 369:130–139. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Yu XM, Jaskulasztul R, Ahmed K, Harrison AD, Kunnimalaiyaan M and Chen H: Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth. Mol Cancer Ther. 12:1276–1287. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Che H, Guo H, Si X, You Q and Lou W: Additive effect by combination of Akt inhibitor, MK-2206, and PDGFR inhibitor, tyrphostin AG 1296, in suppressing anaplastic thyroid carcinoma cell viability and motility. Onco Ther. 7:425–432. 2014.

10 

Reeb AN, Li W, Sewell W, Marlow LA, Tun HW, Smallridge RC, Copland JA, Spradling K, Chernock R and Lin RY: S100A8 is a novel therapeutic target for anaplastic thyroid carcinoma. J Clin Endocrinol Metab. 100:232–242. 2015. View Article : Google Scholar

11 

Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J and Mustelin T: Protein tyrosine phosphatases in the human genome. Cell. 117:699–711. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Korbecki J, Baranowska-Bosiacka I, Gutowska I and Chlubek D: Biochemical and medical importance of vanadium compounds. Acta Biochim Pol. 59:195–200. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Tian X, Fan J, Hou W, Bai S, Ao Q and Tong H: Sodium orthovanadate induces the apoptosis of SH-SY5Y cells by inhibiting PIWIL2. Mol Med Rep. 13:874–880. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Klein A, Holko P, Ligeza J and Kordowiak AM: Sodium orthovanadate affects growth of some human epithelial cancer cells (A549, HTB44, DU145). Folia Biol (Krakow). 56:115–121. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Liu TT, Liu YJ, Wang Q, Yang XG and Wang K: Reactive- oxygen-species-mediated Cdc25C degradation results in differential antiproliferative activities of vanadate, tungstate, and molybdate in the PC-3 human prostate cancer cell line. J Biol Inorg Chem. 17:311–320. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Günther TM, Kviecinski MR, Baron CC, Felipe KB, Farias MS, da Silva FO, Bücker NC, Pich CT, Ferreira EA, Wilhelm Filho D, et al: Sodium orthovanadate associated with pharmacological doses of ascorbate causes an increased generation of ROS in tumor cells that inhibits proliferation and triggers apoptosis. Biochem Biophys Res Commun. 430:883–888. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Wu Y, Ma Y, Xu Z, Wang D, Zhao B, Pan H, Wang J, Xu D, Zhao X, Pan S, et al: Sodium orthovanadate inhibits growth of human hepatocellular carcinoma cells in vitro and in an orthotopic model in vivo. Cancer Lett. 351:108–116. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Kordowiak AM, Klein A, Goc A and Dabroś W: Comparison of the effect of VOSO4, Na3VO4 and NaVO3 on proliferation, viability and morphology of H35-19 rat hepatoma cell line. Pol J Pathol. 58:51–57. 2007.PubMed/NCBI

19 

Reed LJ and Muench H: A simple method of estimating fifty percent endpoints. Am J Hyg. 27:1938.

20 

Ostrowski J, Woszczyński M, Kowalczyk P, Trzeciak L, Hennig E and Bomsztyk K: Treatment of mice with EGF and orthovanadate activates cytoplasmic and nuclear MAPK, p70S6k, and p90rsk in the liver. J Hepatol. 32:965–974. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Choi YJ, Lim SY, Woo JH, Kim YH, Kwon YK, Suh SI, Lee SH, Choi WY, Kim JG, Lee IS, et al: Sodium orthovanadate potentiates EGCG-induced apoptosis that is dependent on the ERK pathway. Biochem Biophys Res Commun. 305:176–185. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Afshari CA, Kodama S, Bivins HM, Willard TB, Fujiki H and Barrett JC: Induction of neoplastic progression in Syrian hamster embryo cells treated with protein phosphatase inhibitors. Cancer Res. 53:1777–1782. 1993.PubMed/NCBI

23 

Hwang JT, Lee M, Jung SN, Lee HJ, Kang I, Kim SS and Ha J: AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 25:24972004. View Article : Google Scholar : PubMed/NCBI

24 

Zhang Z, Huang C, Li J and Shi X: Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells. J Inorg Biochem. 89:142–148. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita M, Suzuki T, Ohtomo K and Hosoi Y: Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. Cell Death Differ. 13:499–511. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Gamero AM and Larner AC: Vanadate facilitates interferon alpha-mediated apoptosis that is dependent on the Jak/Stat pathway. J Bioll Chem. 276:13547–13553. 2001. View Article : Google Scholar

27 

Stewart C, Mihai R and Holly JM: Increased tyrosine kinase activity but not calcium mobilization is required for ceramide-induced apoptosis. Exp Cell Res. 250:329–338. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Guo YL, Baysal K, Kang B, Yang LJ and Williamson JR: Correlation between sustained c-Jun N-terminal protein Kinase activation and apoptosis induced by tumor necrosis factor-α in rat mesangial cells. J Biol Chem. 273:4027–4034. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Figiel I and Kaczmarek L: Orthovanadate induces cell death in rat dentate gyrus primary culture. Neuroreport. 8:2465–2470. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Morita A, Yamamoto S, Wang B, Tanaka K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, et al: Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res. 70:257–265. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Cossarizza A, Franceschi C, Monti D, Salvioli S, Bellesia E, Rivabene R, Biondo L, Rainaldi G, Tinari A and Malorni W: Protective effect of N-acetylcysteine in tumor necrosis factor-alpha-induced apoptosis in U937 cells: The role of mitochondria. Exp Cell Res. 220:232–240. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Ray RS, Ghosh B, Rana A and Chatterjee M: Suppression of cell proliferation, induction of apoptosis and cell cycle arrest: Chemopreventive activity of vanadium in vivo and in vitro. Int J Cancer. 120:13–23. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Kanna P, Mahendrakumar CB, Chakraborty T, Hemalatha P, Banerjee P and Chatterjee M: Effect of vanadium on colonic aberrant crypt loci induced in rats by 1,2 dimethyl hydrazine. World J Gastroenterol. 9:1020–1027. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu Q, Jiang W, Li D, Gu M, Liu K, Dong L, Wang C, Jiang H and Dai W: Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo. Oncol Lett 17: 4255-4262, 2019.
APA
Yu, Q., Jiang, W., Li, D., Gu, M., Liu, K., Dong, L. ... Dai, W. (2019). Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo. Oncology Letters, 17, 4255-4262. https://doi.org/10.3892/ol.2019.10090
MLA
Yu, Q., Jiang, W., Li, D., Gu, M., Liu, K., Dong, L., Wang, C., Jiang, H., Dai, W."Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo". Oncology Letters 17.5 (2019): 4255-4262.
Chicago
Yu, Q., Jiang, W., Li, D., Gu, M., Liu, K., Dong, L., Wang, C., Jiang, H., Dai, W."Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo". Oncology Letters 17, no. 5 (2019): 4255-4262. https://doi.org/10.3892/ol.2019.10090
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Q, Jiang W, Li D, Gu M, Liu K, Dong L, Wang C, Jiang H and Dai W: Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo. Oncol Lett 17: 4255-4262, 2019.
APA
Yu, Q., Jiang, W., Li, D., Gu, M., Liu, K., Dong, L. ... Dai, W. (2019). Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo. Oncology Letters, 17, 4255-4262. https://doi.org/10.3892/ol.2019.10090
MLA
Yu, Q., Jiang, W., Li, D., Gu, M., Liu, K., Dong, L., Wang, C., Jiang, H., Dai, W."Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo". Oncology Letters 17.5 (2019): 4255-4262.
Chicago
Yu, Q., Jiang, W., Li, D., Gu, M., Liu, K., Dong, L., Wang, C., Jiang, H., Dai, W."Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo". Oncology Letters 17, no. 5 (2019): 4255-4262. https://doi.org/10.3892/ol.2019.10090
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