Open Access

Evaluation of the prognostic significances of γ‑secretase genes in pancreatic cancer

  • Authors:
    • Yun Ho Jeon
    • Mihyang Ha
    • Sung Won Kim
    • Mun Ju Kim
    • Chi‑Seung Lee
    • Chang‑Kyu Oh
    • Myoung‑Eun Han
    • Sae‑Ock Oh
    • Yun Hak Kim
  • View Affiliations

  • Published online on: March 5, 2019     https://doi.org/10.3892/ol.2019.10113
  • Pages: 4614-4620
  • Copyright: © Jeon et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

With the growing requirement for novel prognostic biomarkers for pancreatic cancer, many studies have focused on clinical and/or genomic variables. Although many studies have been performed, carbohydrate antigen 19‑9 is the only biomarker in clinical use. Therefore, the present study examined whether γ‑secretase genes, including presenilin (PSEN), nicastrin (NCSTN), presenilin enhancer protein 2 (PSENEN), and anterior pharynx‑defective 1 (APH1‑), could serve as prognostic factors for pancreatic cancer. The cohorts selected included >100 pancreatic cancer patients. Patient data were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GSE21501). The prognostic roles of the γ‑secretase genes were analyzed by several survival analysis methods. Among the γ‑secretase genes, the prognosis tended to be worse in the 2 cohorts with increasing expression of PSEN1, APH1A, and PSENEN, while the remaining genes were the opposite in the 2 cohorts. Notably, although the patient characteristics were quite different, APH1A was statistically significantly associated with prognosis in the 2 cohorts. The hazard ratio of APH1A for overall survival was 1.598 (TCGA) and 2.724 (GSE21501). These results contribute to the study of γ‑secretase in pancreatic cancer. We believe that γ‑secretase, particularly APH1A, will be a new prognostic biomarker for pancreatic cancer.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jeon YH, Ha M, Kim SW, Kim MJ, Lee CS, Oh CK, Han ME, Oh SO and Kim Y: Evaluation of the prognostic significances of γ‑secretase genes in pancreatic cancer. Oncol Lett 17: 4614-4620, 2019
APA
Jeon, Y.H., Ha, M., Kim, S.W., Kim, M.J., Lee, C., Oh, C. ... Kim, Y. (2019). Evaluation of the prognostic significances of γ‑secretase genes in pancreatic cancer. Oncology Letters, 17, 4614-4620. https://doi.org/10.3892/ol.2019.10113
MLA
Jeon, Y. H., Ha, M., Kim, S. W., Kim, M. J., Lee, C., Oh, C., Han, M., Oh, S., Kim, Y."Evaluation of the prognostic significances of γ‑secretase genes in pancreatic cancer". Oncology Letters 17.5 (2019): 4614-4620.
Chicago
Jeon, Y. H., Ha, M., Kim, S. W., Kim, M. J., Lee, C., Oh, C., Han, M., Oh, S., Kim, Y."Evaluation of the prognostic significances of γ‑secretase genes in pancreatic cancer". Oncology Letters 17, no. 5 (2019): 4614-4620. https://doi.org/10.3892/ol.2019.10113