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Article Open Access

High expression of TRIM36 is associated with radiosensitivity in gastric cancer

  • Authors:
    • Zhongsong Man
    • Tao Chen
    • Zhongwei Zhu
    • Haitao Zhang
    • Lei Ao
    • Liting Xi
    • Jin Zhou
    • Zaixiang Tang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China, Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Man et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4401-4408
    |
    Published online on: March 7, 2019
       https://doi.org/10.3892/ol.2019.10122
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Abstract

Radiotherapy is one of the main adjuvant treatments for gastric cancer (GC) that can effectively reduce local recurrence and improve survival rates. However, radiotherapy may result in cytotoxicity and not benefit all patients. This highlights the requirement for identifying potential radiosensitivity genes in GC. The current study investigated the association between tripartite motif containing 36 (TRIM36) status and the prognosis of patients with GC receiving radiotherapy. A total of 371 patients with GC were selected from The Cancer Genome Atlas and randomly divided into test and the validation groups. The results revealed that TRIM36 expression was not associated with the overall survival (OS) rate. Patients who received radiotherapy with high TRIM36 expression had an improved OS rate compared with patients who did not receive radiotherapy in the test group, as demonstrated by univariate analysis [hazard ratio (HR), 0.062; 95% confidence interval (CI), 0.008‑0.462; P=0.007] and multivariate analysis (HR, 0.095; 95% CI, 0.012‑0.748; P=0.025). In the validation group, patients with high TRIM36 expression had decreased mortality risk when they received radiotherapy compared with patients who did not receive radiotherapy, as determined by univariate analysis (HR, 0.190; 95% CI, 0.067‑0.540; P=0.002) and multivariate analysis (HR, 0.075; 95% CI, 0.020‑0.276; P<0.001). However, for patients with low expression, no significant difference was identified in the overall survival rates between the radiotherapy and non‑radiotherapy groups. Chi‑squared analysis revealed that the expression status of TRIM36 was an independent factor and was not associated with clinicopathological factors. The results indicated that patients with high TRIM36 expression receiving radiotherapy exhibited an improved OS rate. TRIM36 may therefore be an important factor affecting the clinical prognosis of patients with GC receiving radiotherapy and may be considered as a potential radiosensitivity gene signature.
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Copy and paste a formatted citation
Spandidos Publications style
Man Z, Chen T, Zhu Z, Zhang H, Ao L, Xi L, Zhou J and Tang Z: High expression of TRIM36 is associated with radiosensitivity in gastric cancer. Oncol Lett 17: 4401-4408, 2019.
APA
Man, Z., Chen, T., Zhu, Z., Zhang, H., Ao, L., Xi, L. ... Tang, Z. (2019). High expression of TRIM36 is associated with radiosensitivity in gastric cancer. Oncology Letters, 17, 4401-4408. https://doi.org/10.3892/ol.2019.10122
MLA
Man, Z., Chen, T., Zhu, Z., Zhang, H., Ao, L., Xi, L., Zhou, J., Tang, Z."High expression of TRIM36 is associated with radiosensitivity in gastric cancer". Oncology Letters 17.5 (2019): 4401-4408.
Chicago
Man, Z., Chen, T., Zhu, Z., Zhang, H., Ao, L., Xi, L., Zhou, J., Tang, Z."High expression of TRIM36 is associated with radiosensitivity in gastric cancer". Oncology Letters 17, no. 5 (2019): 4401-4408. https://doi.org/10.3892/ol.2019.10122
Copy and paste a formatted citation
x
Spandidos Publications style
Man Z, Chen T, Zhu Z, Zhang H, Ao L, Xi L, Zhou J and Tang Z: High expression of TRIM36 is associated with radiosensitivity in gastric cancer. Oncol Lett 17: 4401-4408, 2019.
APA
Man, Z., Chen, T., Zhu, Z., Zhang, H., Ao, L., Xi, L. ... Tang, Z. (2019). High expression of TRIM36 is associated with radiosensitivity in gastric cancer. Oncology Letters, 17, 4401-4408. https://doi.org/10.3892/ol.2019.10122
MLA
Man, Z., Chen, T., Zhu, Z., Zhang, H., Ao, L., Xi, L., Zhou, J., Tang, Z."High expression of TRIM36 is associated with radiosensitivity in gastric cancer". Oncology Letters 17.5 (2019): 4401-4408.
Chicago
Man, Z., Chen, T., Zhu, Z., Zhang, H., Ao, L., Xi, L., Zhou, J., Tang, Z."High expression of TRIM36 is associated with radiosensitivity in gastric cancer". Oncology Letters 17, no. 5 (2019): 4401-4408. https://doi.org/10.3892/ol.2019.10122
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