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Article

IL‑32 expression indicates unfavorable prognosis in patients with colon cancer

  • Authors:
    • Jing‑Ming Zhai
    • Yan‑Hui An
    • Wei Wang
    • Yong‑Gang Fan
    • Guo‑Liang Yao
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital and College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
  • Pages: 4655-4660
    |
    Published online on: March 12, 2019
       https://doi.org/10.3892/ol.2019.10136
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Abstract

Recently, interleukin (IL)‑32 has been demonstrated to represent a novel biomarker for evaluating the prognosis of patients with gastric and lung cancer; however, its clinical significance in colon cancer remains unknown. In the present study, the IL‑32 expression in 60 patients with colon cancer was examined with an immunohistochemistry assay. IL‑32 expression was determined in 37 (61.67%) patients with colon cancer. Additionally, IL‑32 was associated with tumor size and Dukes' stage. By using the Kaplan‑Meier method, patients with positive IL‑32 expression had shorter overall survival time, compared with those with negative IL‑32 expression. Multivariate analysis indicated that IL‑32 could be an independent prognostic factor in patients with colon cancer; therefore, IL‑32 may be a novel prognostic biomarker and therapeutic target for colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhai JM, An YH, Wang W, Fan YG and Yao GL: IL‑32 expression indicates unfavorable prognosis in patients with colon cancer. Oncol Lett 17: 4655-4660, 2019.
APA
Zhai, J., An, Y., Wang, W., Fan, Y., & Yao, G. (2019). IL‑32 expression indicates unfavorable prognosis in patients with colon cancer. Oncology Letters, 17, 4655-4660. https://doi.org/10.3892/ol.2019.10136
MLA
Zhai, J., An, Y., Wang, W., Fan, Y., Yao, G."IL‑32 expression indicates unfavorable prognosis in patients with colon cancer". Oncology Letters 17.5 (2019): 4655-4660.
Chicago
Zhai, J., An, Y., Wang, W., Fan, Y., Yao, G."IL‑32 expression indicates unfavorable prognosis in patients with colon cancer". Oncology Letters 17, no. 5 (2019): 4655-4660. https://doi.org/10.3892/ol.2019.10136
Copy and paste a formatted citation
x
Spandidos Publications style
Zhai JM, An YH, Wang W, Fan YG and Yao GL: IL‑32 expression indicates unfavorable prognosis in patients with colon cancer. Oncol Lett 17: 4655-4660, 2019.
APA
Zhai, J., An, Y., Wang, W., Fan, Y., & Yao, G. (2019). IL‑32 expression indicates unfavorable prognosis in patients with colon cancer. Oncology Letters, 17, 4655-4660. https://doi.org/10.3892/ol.2019.10136
MLA
Zhai, J., An, Y., Wang, W., Fan, Y., Yao, G."IL‑32 expression indicates unfavorable prognosis in patients with colon cancer". Oncology Letters 17.5 (2019): 4655-4660.
Chicago
Zhai, J., An, Y., Wang, W., Fan, Y., Yao, G."IL‑32 expression indicates unfavorable prognosis in patients with colon cancer". Oncology Letters 17, no. 5 (2019): 4655-4660. https://doi.org/10.3892/ol.2019.10136
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