IL‑32 expression indicates unfavorable prognosis in patients with colon cancer

  • Authors:
    • Jing‑Ming Zhai
    • Yan‑Hui An
    • Wei Wang
    • Yong‑Gang Fan
    • Guo‑Liang Yao
  • View Affiliations

  • Published online on: March 12, 2019     https://doi.org/10.3892/ol.2019.10136
  • Pages: 4655-4660
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Recently, interleukin (IL)‑32 has been demonstrated to represent a novel biomarker for evaluating the prognosis of patients with gastric and lung cancer; however, its clinical significance in colon cancer remains unknown. In the present study, the IL‑32 expression in 60 patients with colon cancer was examined with an immunohistochemistry assay. IL‑32 expression was determined in 37 (61.67%) patients with colon cancer. Additionally, IL‑32 was associated with tumor size and Dukes' stage. By using the Kaplan‑Meier method, patients with positive IL‑32 expression had shorter overall survival time, compared with those with negative IL‑32 expression. Multivariate analysis indicated that IL‑32 could be an independent prognostic factor in patients with colon cancer; therefore, IL‑32 may be a novel prognostic biomarker and therapeutic target for colon cancer.
View Figures
View References

Related Articles

Journal Cover

May-2019
Volume 17 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhai JM, An YH, Wang W, Fan YG and Yao GL: IL‑32 expression indicates unfavorable prognosis in patients with colon cancer. Oncol Lett 17: 4655-4660, 2019
APA
Zhai, J., An, Y., Wang, W., Fan, Y., & Yao, G. (2019). IL‑32 expression indicates unfavorable prognosis in patients with colon cancer. Oncology Letters, 17, 4655-4660. https://doi.org/10.3892/ol.2019.10136
MLA
Zhai, J., An, Y., Wang, W., Fan, Y., Yao, G."IL‑32 expression indicates unfavorable prognosis in patients with colon cancer". Oncology Letters 17.5 (2019): 4655-4660.
Chicago
Zhai, J., An, Y., Wang, W., Fan, Y., Yao, G."IL‑32 expression indicates unfavorable prognosis in patients with colon cancer". Oncology Letters 17, no. 5 (2019): 4655-4660. https://doi.org/10.3892/ol.2019.10136