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Article Open Access

The potential role of miR‑126, miR‑21 and miR‑10b as prognostic biomarkers in renal cell carcinoma

  • Authors:
    • Jessica Carlsson
    • Jesper Christiansen
    • Sabina Davidsson
    • Francesca Giunchi
    • Michelangelo Fiorentino
    • Pernilla Sundqvist
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Faculty of Medicine and Health, Örebro University, 701 85 Örebro, Sweden, Department of Surgery, Faculty of Medicine and Health, Örebro University, 701 85 Örebro, Sweden, Department of Pathology, F. Addari Institute of Oncology, S. Orsola Hospital, I‑401 38 Bologna, Italy
    Copyright: © Carlsson et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4566-4574
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    Published online on: March 12, 2019
       https://doi.org/10.3892/ol.2019.10142
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Abstract

Renal cell carcinoma (RCC) is the most commonly diagnosed renal tumor, consisting of ~3% of all malignancies worldwide. The prognosis of RCC can vary widely, and detecting patients at risk of recurrence at an early stage of disease may improve patient outcome. The factors presently used in a clinical setting cannot reliably predict the natural history of the disease. Therefore, there is a requirement to identify novel biomarkers that can aid in predicting patient outcome. Previous studies have indicated that microRNAs (miRNAs/miRs) are potential candidates as prognostic biomarkers for patients suffering from RCC. Consequently, the aims of the present study were to validate the potential of 3 of these miRNAs to predict the prognosis of patients with RCC, and to investigate the stability of endogenous control genes for miRNA studies in RCC tissues. The expression of 7 endogenous controls was measured using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) in formalin‑fixed paraffin‑embedded tumor and benign tissues from patients suffering from clear cell RCC (ccRCC). The analyses identified RNU48 and U47 as the most stable endogenous controls. The expression of miR‑126, miR‑21 and miR‑10b was analyzed using RT‑qPCR in renal tissues from 116 patients diagnosed with ccRCC. All three investigated miRNAs were differentially expressed between malignant and benign tissues. miR‑126 and miR‑10b were also differentially expressed between grades and stages of ccRCC. In a univariate, but not in a multivariate model, low expression of miR‑126 was associated with shorter time to recurrence of the disease. The results of the present study indicate that of the 3 miRNAs investigated, the expression of miR‑126 has the strongest potential as a prognostic biomarker for patients suffering from ccRCC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Lopez-Beltran A, Carrasco JC, Cheng L, Scarpelli M, Kirkali Z and Montironi R: 2009 update on the classification of renal epithelial tumors in adults. Int J Urol. 16:432–443. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Ljungberg B, Alamdari FI, Rasmuson T and Roos G: Follow-up guidelines of nonmetastatic renal cell carcinoma based on the occurrence of metastases after radical nephrectomy. BJU Int. 84:405–411. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Regional Cancer Center: Renal cancer-National quality register report of 2015. https://www.cancercentrum.se/globalassets/cancerdiagnoser/urinvagar/njurcancer/natvp_njurcancer_2017-09-13_final.pdf?v=c90d6e26233847b9801df004ceb97ae2October 13–2017(In Swedish).

5 

Diaz de Leon A and Pedrosa I: Imaging and screening of kidney cancer. Radiol Clin North Am. 55:1235–1250. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Azawi NH, Lund L and Fode M: Renal cell carcinomas mass of <4 cm are not always indolent. Urol Ann. 9:234–238. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Delahunt B, Srigley JR, Montironi R and Egevad L: Advances in renal neoplasia: Recommendations from the 2012 international society of urological pathology consensus conference. Urology. 83:969–974. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Nerich V, Hugues M, Paillard MJ, Borowski L, Nai T, Stein U, Nguyen Tan Hon T, Montcuquet P, Maurina T, Mouillet G, et al: Clinical impact of targeted therapies in patients with metastatic clear-cell renal cell carcinoma. Onco Targets Ther. 7:365–374. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Heng DY, Xie W, Regan MM, Harshman LC, Bjarnason GA, Vaishampayan UN, Mackenzie M, Wood L, Donskov F, Tan MH, et al: External validation and comparison with other models of the international metastatic renal-cell carcinoma database consortium prognostic model: A population-based study. Lancet Oncol. 14:141–148. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI

11 

Brennecke J, Hipfner DR, Stark A, Russell RB and Cohen SM: bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell. 113:25–36. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Chen CZ, Li L, Lodish HF and Bartel DP: MicroRNAs modulate hematopoietic lineage differentiation. Science. 303:83–86. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Backes C, Meese E, Lenhof HP and Keller A: A dictionary on microRNAs and their putative target pathways. Nucleic Acids Res. 38:4476–4486. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Faragalla H, Youssef YM, Scorilas A, Khalil B, White NM, Mejia-Guerrero S, Khella H, Jewett MA, Evans A, Lichner Z, et al: The clinical utility of miR-21 as a diagnostic and prognostic marker for renal cell carcinoma. J Mol Diagn. 14:385–392. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Vergho D, Kneitz S, Rosenwald A, Scherer C, Spahn M, Burger M, Riedmiller H and Kneitz B: Combination of expression levels of miR-21 and miR-126 is associated with cancer-specific survival in clear-cell renal cell carcinoma. BMC Cancer. 14:252014. View Article : Google Scholar : PubMed/NCBI

16 

Fritz HKM, Lindgren D, Ljungberg B, Axelson H and Dahlback B: The miR(21/10b) ratio as a prognostic marker in clear cell renal cell carcinoma. Eur J Cancer. 50:1758–1765. 2014. View Article : Google Scholar : PubMed/NCBI

17 

He C, Zhao X, Jiang H, Zhong Z and Xu R: Demethylation of miR-10b plays a suppressive role in ccRCC cells. Int J Clin Exp Pathol. 8:10595–10604. 2015.PubMed/NCBI

18 

Khella HWZ, Daniel N, Youssef L, Scorilas A, Nofech-Mozes R, Mirham L, Krylov SN, Liandeau E, Krizova A, Finelli A, et al: miR-10b is a prognostic marker in clear cell renal cell carcinoma. J Clin Pathol. 70:854–859. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Khella HW, Scorilas A, Mozes R, Mirham L, Lianidou E, Krylov SN, Lee JY, Ordon M, Stewart R, Jewett MA and Yousef GM: Low expression of miR-126 is a prognostic marker for metastatic clear cell renal cell carcinoma. Am J Pathol. 185:693–703. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Vergho DC, Kneitz S, Kalogirou C, Burger M, Krebs M, Rosenwald A, Spahn M, Löser A, Kocot A, Riedmiller H and Kneitz B: Impact of miR-21, miR-126 and miR-221 as prognostic factors of clear cell renal cell carcinoma with tumor thrombus of the inferior vena cava. PLoS One. 9:e1098772014. View Article : Google Scholar : PubMed/NCBI

21 

Zaman MS, Shahryari V, Deng G, Thamminana S, Saini S, Majid S, Chang I, Hirata H, Ueno K, Yamamura S, et al: Up-regulation of microRNA-21 correlates with lower kidney cancer survival. PLoS One. 7:e310602012. View Article : Google Scholar : PubMed/NCBI

22 

Lu Z, Liu M, Stribinskis V, Klinge CM, Ramos KS, Colburn NH and Li Y: MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene. 27:4373–4379. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Zhang A, Liu Y, Shen Y, Xu Y and Li X: miR-21 modulates cell apoptosis by targeting multiple genes in renal cell carcinoma. Urology. 78:474 e413–479. 2011. View Article : Google Scholar

24 

Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 133:647–658. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S and Allgayer H: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene. 27:2128–2136. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Zhu S, Wu H, Wu F, Nie D, Sheng S and Mo YY: MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 18:350–359. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Liu SG, Qin XG, Zhao BS, Qi B, Yao WJ, Wang TY, Li HC and Wu XN: Differential expression of miRNAs in esophageal cancer tissue. Oncol Lett. 5:1639–1642. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Guan P, Yin Z, Li X, Wu W and Zhou B: Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues. J Exp Clin Cancer Res. 31:542012. View Article : Google Scholar : PubMed/NCBI

29 

Snowdon J, Boag S, Feilotter H, Izard J and Siemens DR: A pilot study of urinary microRNA as a biomarker for urothelial cancer. Can Urol Assoc J. 7:28–32. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Otsubo T, Akiyama Y, Hashimoto Y, Shimada S, Goto K and Yuasa Y: MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS One. 6:e166172011. View Article : Google Scholar : PubMed/NCBI

31 

Liu B, Peng XC, Zheng XL, Wang J and Qin YW: MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer. 66:169–175. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Zhu N, Zhang D, Xie H, Zhou Z, Chen H, Hu T, Bai Y, Shen Y, Yuan W, Jing Q and Qin Y: Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. Mol Cell Biochem. 351:157–164. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Guo C, Sah JF, Beard L, Willson JK, Markowitz SD and Guda K: The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer. 47:939–946. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Harris TA, Yamakuchi M, Ferlito M, Mendell JT and Lowenstein CJ: MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA. 105:1516–1521. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Ahmad A, Sethi S, Chen W, Ali-Fehmi R, Mittal S and Sarkar FH: Up-regulation of microRNA-10b is associated with the development of breast cancer brain metastasis. Am J Transl Res. 6:384–390. 2014.PubMed/NCBI

36 

Wang YY, Li L, Ye ZY, Zhao ZS and Yan ZL: MicroRNA-10b promotes migration and invasion through Hoxd10 in human gastric cancer. World J Surg Oncol. 13:2592015. View Article : Google Scholar : PubMed/NCBI

37 

Sun L, Yan W, Wang Y, Sun G, Luo H, Zhang J, Wang X, You Y, Yang Z and Liu N: MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10. Brain Res. 1389:9–18. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Li Y, Chen D, Jin L, Liu J, Su Z, Qi Z, Shi M, Jiang Z, Ni L, Yang S, et al: Oncogenic cAMP responsive element binding protein 1 is overexpressed upon loss of tumor suppressive miR-10b-5p and miR-363-3p in renal cancer. Oncol Rep. 35:1967–1978. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Andersen CL, Jensen JL and Orntoft TF: Normalization of real-time quantitative reverse transcription-PCR data: A model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 64:5245–5250. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Edge SB, Byrd D, Compton C, Fritz AG, Greene FL and Trotti A III: AJCC cancer staging manual (7th). Springer-Verlag. New York, NY: 2010.

42 

Fuhrman SA, Lasky LC and Limas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 6:655–663. 1982. View Article : Google Scholar : PubMed/NCBI

43 

Heinzelmann J, Henning B, Sanjmyatav J, Posorski N, Steiner T, Wunderlich H, Gajda MR and Junker K: Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. World J Urol. 29:367–373. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Juan D, Alexe G, Antes T, Liu H, Madabhushi A, Delisi C, Ganesan S, Bhanot G and Liou LS: Identification of a microRNA panel for clear-cell kidney cancer. Urology. 75:835–841. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Jung M, Mollenkopf HJ, Grimm C, Wagner I, Albrecht M, Waller T, Pilarsky C, Johannsen M, Stephan C, Lehrach H, et al: MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy. J Cell Mol Med. 13:3918–3928. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Osanto S, Qin Y, Buermans HP, Berkers J, Lerut E, Goeman JJ and van Poppel H: Genome-wide microRNA expression analysis of clear cell renal cell carcinoma by next generation deep sequencing. PLoS One. 7:e382982012. View Article : Google Scholar : PubMed/NCBI

47 

Slaby O, Redova M, Poprach A, Nekvindova J, Iliev R, Radova L, Lakomy R, Svoboda M and Vyzula R: Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients. Genes Chromosomes Cancer. 51:707–716. 2012. View Article : Google Scholar : PubMed/NCBI

48 

White NM, Khella HW, Grigull J, Adzovic S, Youssef YM, Honey RJ, Stewart R, Pace KT, Bjarnason GA, Jewett MA, et al: miRNA profiling in metastatic renal cell carcinoma reveals a tumour-suppressor effect for miR-215. Br J Cancer. 105:1741–1749. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Wotschofsky Z, Liep J, Meyer HA, Jung M, Wagner I, Disch AC, Schaser KD, Melcher I, Kilic E, Busch J, et al: Identification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas. Int J Biol Sci. 8:1363–1374. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Yi Z, Fu Y, Zhao S, Zhang X and Ma C: Differential expression of miRNA patterns in renal cell carcinoma and nontumorous tissues. J Cancer Res Clin Oncol. 136:855–862. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Peltier HJ and Latham GJ: Normalization of microRNA expression levels in quantitative RT-PCR assays: Identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA. 14:844–852. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A and Speleman F: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3:RESEARCH00342002. View Article : Google Scholar : PubMed/NCBI

53 

Tricarico C, Pinzani P, Bianchi S, Paglierani M, Distante V, Pazzagli M, Bustin SA and Orlando C: Quantitative real-time reverse transcription polymerase chain reaction: Normalization to rRNA or single housekeeping genes is inappropriate for human tissue biopsies. Anal Biochem. 309:293–300. 2002. View Article : Google Scholar : PubMed/NCBI

54 

Youssef YM, White NM, Grigull J, Krizova A, Samy C, Mejia-Guerrero S, Evans A and Yousef GM: Accurate molecular classification of kidney cancer subtypes using microRNA signature. Eur Urol. 59:721–730. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Zhang KL, Han L, Chen LY, Shi ZD, Yang M, Ren Y, Chen LC, Zhang JX, Pu PY and Kang CS: Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas. Cancer Lett. 342:139–149. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Ma L, Teruya-Feldstein J and Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 449:682–688. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Carlsson J, Christiansen J, Davidsson S, Giunchi F, Fiorentino M and Sundqvist P: The potential role of miR‑126, miR‑21 and miR‑10b as prognostic biomarkers in renal cell carcinoma. Oncol Lett 17: 4566-4574, 2019.
APA
Carlsson, J., Christiansen, J., Davidsson, S., Giunchi, F., Fiorentino, M., & Sundqvist, P. (2019). The potential role of miR‑126, miR‑21 and miR‑10b as prognostic biomarkers in renal cell carcinoma. Oncology Letters, 17, 4566-4574. https://doi.org/10.3892/ol.2019.10142
MLA
Carlsson, J., Christiansen, J., Davidsson, S., Giunchi, F., Fiorentino, M., Sundqvist, P."The potential role of miR‑126, miR‑21 and miR‑10b as prognostic biomarkers in renal cell carcinoma". Oncology Letters 17.5 (2019): 4566-4574.
Chicago
Carlsson, J., Christiansen, J., Davidsson, S., Giunchi, F., Fiorentino, M., Sundqvist, P."The potential role of miR‑126, miR‑21 and miR‑10b as prognostic biomarkers in renal cell carcinoma". Oncology Letters 17, no. 5 (2019): 4566-4574. https://doi.org/10.3892/ol.2019.10142
Copy and paste a formatted citation
x
Spandidos Publications style
Carlsson J, Christiansen J, Davidsson S, Giunchi F, Fiorentino M and Sundqvist P: The potential role of miR‑126, miR‑21 and miR‑10b as prognostic biomarkers in renal cell carcinoma. Oncol Lett 17: 4566-4574, 2019.
APA
Carlsson, J., Christiansen, J., Davidsson, S., Giunchi, F., Fiorentino, M., & Sundqvist, P. (2019). The potential role of miR‑126, miR‑21 and miR‑10b as prognostic biomarkers in renal cell carcinoma. Oncology Letters, 17, 4566-4574. https://doi.org/10.3892/ol.2019.10142
MLA
Carlsson, J., Christiansen, J., Davidsson, S., Giunchi, F., Fiorentino, M., Sundqvist, P."The potential role of miR‑126, miR‑21 and miR‑10b as prognostic biomarkers in renal cell carcinoma". Oncology Letters 17.5 (2019): 4566-4574.
Chicago
Carlsson, J., Christiansen, J., Davidsson, S., Giunchi, F., Fiorentino, M., Sundqvist, P."The potential role of miR‑126, miR‑21 and miR‑10b as prognostic biomarkers in renal cell carcinoma". Oncology Letters 17, no. 5 (2019): 4566-4574. https://doi.org/10.3892/ol.2019.10142
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