Open Access

Liquid biopsy for lung cancer immunotherapy (Review)

  • Authors:
    • Liang‑Liang Cai
    • Jie Wang
  • View Affiliations

  • Published online on: March 19, 2019     https://doi.org/10.3892/ol.2019.10166
  • Pages: 4751-4760
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The recent successful use of the immune checkpoint inhibitors (CPIs) anti‑programmed death receptor‑1 (PD‑1)/PD‑1 ligand 1 in clinical trials indicates their crucial role in obtaining an effective cancer immune therapy. These CPIs have been identified to have an effective therapeutic response, particularly in tumors with high tumor mutation burden. Targeting private somatic mutations encoding immunogenic neoantigens (neo‑Ags) has been developed as an autologous gene therapy. T‑cell receptor‑engineered T cells targeting neo‑Ags are a novel option for adoptive cell therapy used for the treatment of lung cancer. However, not all patients experience an effective response from immunotherapy. Although the resistance mechanism of CPIs has been reported, its association with other treatment methods during systemic anticancer therapy remains unclear, particularly the treatment options following the emergence of drug resistance in lung cancer. The potential biomarkers used for liquid biopsy may assist in the identification of patients who would benefit the most from immunotherapy. Attempts to identify potential biomarkers for predicting clinical response to immunotherapy are underway. With regard to liquid biopsy, the present review summarizes and discusses the lung cancer management of immunotherapy for precision medicine by reviewing recent literature and associated clinical trials.
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June-2019
Volume 17 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Cai LL and Cai LL: Liquid biopsy for lung cancer immunotherapy (Review). Oncol Lett 17: 4751-4760, 2019
APA
Cai, L., & Cai, L. (2019). Liquid biopsy for lung cancer immunotherapy (Review). Oncology Letters, 17, 4751-4760. https://doi.org/10.3892/ol.2019.10166
MLA
Cai, L., Wang, J."Liquid biopsy for lung cancer immunotherapy (Review)". Oncology Letters 17.6 (2019): 4751-4760.
Chicago
Cai, L., Wang, J."Liquid biopsy for lung cancer immunotherapy (Review)". Oncology Letters 17, no. 6 (2019): 4751-4760. https://doi.org/10.3892/ol.2019.10166