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Article

Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple‑negative breast cancer

  • Authors:
    • Nitin T. Telang
    • Hareesh B. Nair
    • George Y.C. Wong
  • View Affiliations / Copyright

    Affiliations: Cancer Prevention Research Program, Palindrome Liaisons Consultants, Montvale, NJ 07645, USA, Department of Obstetrics and Gynecology, University of Texas Health Sciences Center, San Antonio, TX 78229, USA, American Foundation for Chinese Medicine, New York, NY 11103, USA
  • Pages: 5261-5266
    |
    Published online on: March 21, 2019
       https://doi.org/10.3892/ol.2019.10182
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Abstract

Triple‑negative breast cancer (TNBC) lacks the expressions of estrogen receptor‑α, progesterone receptor and human epidermal growth factor receptor‑2. The treatment options for TNBC include anthracyclin/taxol based conventional chemotherapy and small molecular inhibitor based targeted therapy. However, the therapeutic efficacy is limited by systemic toxicity and acquired tumor resistance; identification of less toxic testable alternatives is urgently required. Non‑toxic nutritional herbs are commonly used in traditional Chinese herbal medicine for general health management and may additionally represent a testable therapeutic alternative for TNBC. The present study examined the growth inhibitory efficacy of the nutritional herb Cornus officinalis (CO) in MDA‑MB‑231 cells, which represent a cell culture model for TNBC, and identified potential mechanistic leads. In MDA‑MB‑231 cells, CO induced dose‑dependent cytostatic growth arrest [inhibitory concentration (IC)50, 0.1% and IC90, 0.5%], and inhibited anchorage independent colony formation. Mechanistically, CO inhibited G1 to S phase transition leading to G1 arrest and decreased the expression of cyclin D1 and phosphorylated‑retinoblastoma proteins. CO additionally altered apoptosis specific BCL‑2 associated X protein/B‑cell lymphoma‑2 expression and upregulated pro‑apoptotic caspase‑3/7 activity. Collectively, these data provided mechanistic evidence for the efficacy of CO, and validated a mechanism‑based approach to prioritize efficacious nutritional herbs as testable alternatives for secondary prevention/treatment of TNBC.
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Copy and paste a formatted citation
Spandidos Publications style
Telang NT, Nair HB and Wong GY: Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple‑negative breast cancer. Oncol Lett 17: 5261-5266, 2019.
APA
Telang, N.T., Nair, H.B., & Wong, G.Y. (2019). Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple‑negative breast cancer. Oncology Letters, 17, 5261-5266. https://doi.org/10.3892/ol.2019.10182
MLA
Telang, N. T., Nair, H. B., Wong, G. Y."Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple‑negative breast cancer". Oncology Letters 17.6 (2019): 5261-5266.
Chicago
Telang, N. T., Nair, H. B., Wong, G. Y."Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple‑negative breast cancer". Oncology Letters 17, no. 6 (2019): 5261-5266. https://doi.org/10.3892/ol.2019.10182
Copy and paste a formatted citation
x
Spandidos Publications style
Telang NT, Nair HB and Wong GY: Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple‑negative breast cancer. Oncol Lett 17: 5261-5266, 2019.
APA
Telang, N.T., Nair, H.B., & Wong, G.Y. (2019). Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple‑negative breast cancer. Oncology Letters, 17, 5261-5266. https://doi.org/10.3892/ol.2019.10182
MLA
Telang, N. T., Nair, H. B., Wong, G. Y."Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple‑negative breast cancer". Oncology Letters 17.6 (2019): 5261-5266.
Chicago
Telang, N. T., Nair, H. B., Wong, G. Y."Growth inhibitory efficacy of Cornus officinalis in a cell culture model for triple‑negative breast cancer". Oncology Letters 17, no. 6 (2019): 5261-5266. https://doi.org/10.3892/ol.2019.10182
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