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Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma

  • Authors:
    • Qingxu Liu
    • Yan Gao
    • Yongxue Wang
    • Jiexin Du
    • Qiang Yin
    • Kewei Shi
  • View Affiliations / Copyright

    Affiliations: Department of Medical Imaging, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China, Department of Radiology, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Department of Medical Records, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Neurology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Ward 1, Department of Oncology, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5635-5641
    |
    Published online on: April 8, 2019
       https://doi.org/10.3892/ol.2019.10228
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Abstract

Diagnostic value of hepatic artery perfusion fraction (HAF) combined with transforming growth factor-β (TGF-β) in the diagnosis of primary liver carcinoma (PLC) was evaluated. The clinical data of 128 PLC patients undergoing radical hepatectomy in Affiliated Hospital of Jining Medical University were regarded as the study group. Seventy‑four healthy volunteers examined in Affiliated Hospital of Jining Medical University were collected as the control group. Double-antibody sandwich enzyme-linked immunosorbent assay was used to detect the expression level of serum TGF-β. The upper abdomen of the subjects was scanned by a 64-slice spiral CT, and the perfusion parameters were analyzed and calculated. According to the HAF and the expression level of TGF-β in the two groups, single and combined detection of TGF-β and HAF parameters were detected, respectively, by ROC curve. The expression of TGF-β in serum of the study group was higher than that of the control group (P<0.05). The expression level of serum TGF-β was closely related to total bilirubin, ascites, TNM stage, prothrombin time and tumor diameter. Blood flow (BF), blood volume (BV), permeability surface (PS), HAF and other perfusion parameters in the study group were higher than those in the control group (P<0.05). The specificity and sensitivity of TGF-β expression level in diagnosing PLC were 73 and 93%, respectively; the specificity and sensitivity of HAF parameter in diagnosing PLC were 73 and 100%, respectively; the specificity and sensitivity of HAF parameter combined with TGF-β expression level were 84 and 100%, respectively. TGF-β is highly expressed in serum of PLC patients; HAF parameter combined with TGF-β expression level can improve the specificity and has an important value in the diagnosis of PLC, which is worthy of clinical promotion.
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1 

Valery PC, Laversanne M, Clark PJ, Petrick JL, McGlynn KA and Bray F: Projections of primary liver cancer to 2030 in 30 countries worldwide. Hepatology. 67:22017.

2 

Tsai WC, Kung PT, Wang YH, Kuo WY and Li YH: Influence of the time interval from diagnosis to treatment on survival for early-stage liver cancer. PLoS One. 13:e01995322018. View Article : Google Scholar : PubMed/NCBI

3 

Giunchi F, Vasuri F, Baldin P, Rosini F, Corti B and D'Errico-Grigioni A: Primary liver sarcomatous carcinoma: Report of two cases and review of the literature. Pathol Res Pract. 209:249–254. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Chuang SC, Lee YC, Hashibe M, Dai M, Zheng T and Boffetta P: Interaction between cigarette smoking and hepatitis B and C virus infection on the risk of liver cancer: A meta-analysis. Cancer Epidemiol Biomarkers Prev. 19:1261–1268. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Romani S, Azimzadeh P, Mohebbi SR, Kazemian S, Almasi S, Naghoosi H, Derakhshan F and Zali MR: Investigation of transforming growth factor-β1 gene polymorphisms among Iranian patients with chronic hepatitis C. Hepat Mon. 11:901–906. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Yao H, Chen H, Chen J, Zhu J and Zhang Y: Long-term survival trends for liver cancer in Qidong: 1972 to 2011. Zhonghua Gan Zang Bing Za Zhi. 22:921–925. 2014.(In Chinese). PubMed/NCBI

7 

Barranger E, Cortez A, Uzan S, Callard P and Darai E: Value of intraoperative imprint cytology of sentinel nodes in patients with cervical cancer. Gynecol Oncol. 94:175–180. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Zheng R, Zuo T, Zeng H, Zhang S and Chen W: Mortality and survival analysis of liver cancer in China. Zhonghua Zhong Liu Za Zhi. 37:697–702. 2015.(In Chinese). PubMed/NCBI

9 

Finnson KW, Arany PR and Philip A: Transforming growth factor beta signaling in cutaneous wound healing: Lessons learned from animal studies. Adv Wound Care (New Rochelle). 2:225–237. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Ahn YO, Lee JC, Sung MW and Heo DS: Presence of membrane-bound TGF-beta1 and its regulation by IL-2-activated immune cell-derived IFN-gamma in head and neck squamous cell carcinoma cell lines. J Immunol. 182:6114–6120. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Fu BH, Fu ZZ, Meng W, Gu T, Sun XD and Zhang Z: Platelet VEGF and serum TGF-β1 levels predict chemotherapy response in non-small cell lung cancer patients. Tumour Biol. 36:6477–6483. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Dumitrescu CI, Gheonea IA, Săndulescu L, Surlin V, Săftoiu A and Dumitrescu D: Contrast enhanced ultrasound and magnetic resonance imaging in hepatocellular carcinoma diagnosis. Med Ultrason. 15:261–267. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Noebauer-Huhmann IM, Szomolanyi P, Kronnerwetter C, Widhalm G, Weber M, Nemec S, Juras V, Ladd ME, Prayer D and Trattnig S: Brain tumours at 7T MRI compared to 3T - contrast effect after half and full standard contrast agent dose: Initial results. Eur Radiol. 25:106–112. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Regan F, Beall DP, Bohlman ME, Khazan R, Sufi A and Schaefer DC: Fast MR imaging and the detection of small-bowel obstruction. AJR Am J Roentgenol. 170:1465–1469. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Patel V, Chityala RN, Hoffmann KR, Ionita CN, Bednarek DR and Rudin S: Self-calibration of a cone-beam micro-CT system. Med Phys. 36:48–58. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Fujimoto S, Giannopoulos AA, Kumamaru KK, Matsumori R, Tang A, Kato E, Kawaguchi Y, Takamura K, Miyauchi K, Daida H, et al: The transluminal attenuation gradient in coronary CT angiography for the detection of hemodynamically significant disease: Can all arteries be treated equally? Br J Radiol. 91:201800432018. View Article : Google Scholar : PubMed/NCBI

17 

Cui HZ, Dai GH, Shi Y and Chen L: Sorafenib combined with TACE in advanced primary hepatocellular carcinoma. Hepatogastroenterology. 60:305–310. 2013.PubMed/NCBI

18 

Chung KY and Kemeny N: Regional and systemic chemotherapy for primary hepatobiliary cancers and for colorectal cancer metastatic to the liver. Semin Radiat Oncol. 15:284–298. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Nderitu P, Bosco C, Garmo H, Holmberg L, Malmström H, Hammar N, Walldius G, Jungner I, Ross P and Van Hemelrijck M: The association between individual metabolic syndrome components, primary liver cancer and cirrhosis: A study in the Swedish AMORIS cohort. Int J Cancer. 141:1148–1160. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Raju J and Bird RP: Differential modulation of transforming growth factor-betas and cyclooxygenases in the platelet lysates of male F344 rats by dietary lipids and piroxicam. Mol Cell Biochem. 231:139–146. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Kloen P, Gebhardt MC, Perez-Atayde A, Rosenberg AE, Springfield DS, Gold LI and Mankin HJ: Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression. Cancer. 80:2230–2239. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Chen HY, Chen ZX, Huang RF, Lin N and Wang XZ: Hepatitis B virus X protein activates human hepatic stellate cells through upregulating TGFβ1. Genet Mol Res. 13:8645–8656. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Dong YD, Cui L, Peng CH, Cheng DF, Han BS and Huang F: Expression and clinical significance of HMGB1 in human liver cancer: Knockdown inhibits tumor growth and metastasis in vitro and in vivo. Oncol Rep. 29:87–94. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Song BC, Chung YH, Kim JA, Choi WB, Suh DD, Pyo SI, Shin JW, Lee HC, Lee YS and Suh DJ: Transforming growth factor-beta1 as a useful serologic marker of small hepatocellular carcinoma. Cancer. 94:175–180. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Jain AR, Jain M, Kanthala AR, Damania D, Stead LG, Wang HZ and Jahromi BS: Association of CT perfusion parameters with hemorrhagic transformation in acute ischemic stroke. AJNR Am J Neuroradiol. 34:1895–1900. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Zhang Q, Zhang XL, Zhang YZ, Cheng GX and Chen ZQ: Hemodynamic study of primary hepatocellular carcinoma evolved from viral-induced cirrhosis using CT perfusion imaging. Nan Fang Yi Ke Da Xue Xue Bao. 28:1986–1989. 2008.(In Chinese). PubMed/NCBI

27 

Bilezikçi B, Haberal AN and Demirhan B: Hepatocyte growth factor in patients with three different stages of chronic liver disease including hepatocellular carcinoma, cirrhosis and chronic hepatitis: An immunohistochemical study. Can J Gastroenterol. 15:159–165. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Lu DD, Zhang XR and Cao XR: Expression and significance of new tumor suppressor gene PTEN in primary liver cancer. J Cell Mol Med. 7:67–71. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Li JP, Feng GL, Li DQ, Wang HB, Zhao DL, Wan Y and Jiang HJ: Detection and differentiation of early hepatocellular carcinoma from cirrhosis using CT perfusion in a rat liver model. Hepatobiliary Pancreat Dis Int. 15:612–618. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Q, Gao Y, Wang Y, Du J, Yin Q and Shi K: Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma. Oncol Lett 17: 5635-5641, 2019.
APA
Liu, Q., Gao, Y., Wang, Y., Du, J., Yin, Q., & Shi, K. (2019). Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma. Oncology Letters, 17, 5635-5641. https://doi.org/10.3892/ol.2019.10228
MLA
Liu, Q., Gao, Y., Wang, Y., Du, J., Yin, Q., Shi, K."Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma". Oncology Letters 17.6 (2019): 5635-5641.
Chicago
Liu, Q., Gao, Y., Wang, Y., Du, J., Yin, Q., Shi, K."Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma". Oncology Letters 17, no. 6 (2019): 5635-5641. https://doi.org/10.3892/ol.2019.10228
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, Gao Y, Wang Y, Du J, Yin Q and Shi K: Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma. Oncol Lett 17: 5635-5641, 2019.
APA
Liu, Q., Gao, Y., Wang, Y., Du, J., Yin, Q., & Shi, K. (2019). Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma. Oncology Letters, 17, 5635-5641. https://doi.org/10.3892/ol.2019.10228
MLA
Liu, Q., Gao, Y., Wang, Y., Du, J., Yin, Q., Shi, K."Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma". Oncology Letters 17.6 (2019): 5635-5641.
Chicago
Liu, Q., Gao, Y., Wang, Y., Du, J., Yin, Q., Shi, K."Diagnostic value of hepatic artery perfusion fraction combined with TGF-β in patients with hepatocellular carcinoma". Oncology Letters 17, no. 6 (2019): 5635-5641. https://doi.org/10.3892/ol.2019.10228
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