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Article

Association of low expression of E‑cadherin and β‑catenin with the progression of early stage human squamous cervical cancer

  • Authors:
    • Jing Jiang
    • Xinling Li
    • Xiangmei Yin
    • Jieying Zhang
    • Bin Shi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Pathology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
  • Pages: 5729-5739
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    Published online on: April 18, 2019
       https://doi.org/10.3892/ol.2019.10266
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Abstract

The precise involvement and mechanisms of human papilloma virus type 16 (HPV16) in epithelial‑mesenchymal transition (EMT) of cervical intraepithelial neoplasia (CIN) and squamous cervical cancer (SCC) remain unknown. The present study aimed to examine the expression of EMT indicators and their association with HPV16 in CIN and early stage SCC, and their prognostic value in early stage SCC. The expression levels of E‑cadherin, N‑cadherin, β‑catenin, vimentin, and fibronectin were determined by immunohistochemistry in 40 patients with normal uterine cervix, 22 patients with CIN1, 60 patients with CIN2‑3, and 86 patients with SCC, stage Ia‑IIa, according to the International Federation of Gynecology and Obstetrics. The expression of the epithelial indicators E‑cadherin and β‑catenin gradually declined, and the mesenchymal indicators N‑cadherin, vimentin, and fibronectin increased with progression of the cervical lesions (P<0.05). Patients with SCC with lymph node metastasis, parametrial invasion, negative E‑cadherin, and negative β‑catenin expression had shorter overall survival (P=0.001, P=0.015, P=0.014, and P=0.043, respectively) and disease‑free survival (P=0.002, P=0.021, P=0.025, and P=0.045, respectively) time. Multivariate survival analysis indicated that lymph node metastasis [Hazard ratio (HR)=3.544; P=0.010], parametrial invasion (HR=2.014; P=0.007) and E‑cadherin expression (HR=0.163; P<0.001) were independently associated with overall survival, but also with disease‑free survival (HR=3.612, P=0.009; HR=1.935, P=0.011; HR=0.168, P<0.001, respectively). In patients with CINs, HPV16 infection was negatively correlated with the expression of E‑cadherin, and positively correlated with the expression of N‑cadherin, vimentin, and fibronectin. EMT occurs during the progression of CINs to early stage SCC, and is associated with HPV16 infection in CINs. Lymph node metastasis and parametrial invasion are poor prognostic factors for SCC, while positive E‑cadherin expression may serve as a protective prognostic factor for SCC.
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View References

1 

Lertkhachonsuk AA, Yip CH, Khuhaprema T, Chen DS, Plummer M, Jee SH, Toi M and Wilailak S; Asian Oncology Summit 2013, : Cancer prevention in Asia: Resource-stratified guidelines from the Asian Oncology Summit, 2013. Lancet Oncol. 14:e497–e507. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Stanley M: Pathology and epidemiology of HPV infection in females. Gynecol Oncol 117 (2 Suppl). S5–S10. 2010. View Article : Google Scholar

3 

Clifford GM, Smith JS, Plummer M, Muñoz N and Franceschi S: Human papillomavirus types in invasive cervical cancer worldwide: A meta-analysis. Br J Cancer. 88:63–73. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Jiang J, Wei LH, Li YL, Wu RF, Xie X, Feng YJ, Zhang G, Zhao C, Zhao Y and Chen Z: Detection of TERC amplification in cervical epithelial cells for the diagnosis of high-grade cervical lesions and invasive cancer: A multicenter study in China. J Mol Diagn. 12:808–817. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Geiger TR and Peeper DS: Metastasis mechanisms. Biochim Biophys Acta. 1796:293–308. 2009.PubMed/NCBI

7 

Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Guarino M, Rubino B and Ballabio G: The role of epithelial-mesenchymal transition in cancer pathology. Pathology. 39:305–318. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Zhau HE, Odero-Marah V, Lue HW, Nomura T, Wang R, Chu G, Liu ZR, Zhou BP, Huang WC and Chung LW: Epithelial to mesenchymal transition (EMT) in human prostate cancer: Lessons learned from ARCaP model. Clin Exp Metastasis. 25:601–610. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, Peng WL and Wu JC: Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology. 50:1464–1474. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Gjerdrum C, Tiron C, Høiby T, Stefansson I, Haugen H, Sandal T, Collett K, Li S, McCormack E, Gjertsen BT, et al: Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc Natl Acad Sci USA. 107:1124–1129. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Chambers AF, Groom AC and MacDonald IC: Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2:563–572. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Guarino M: Epithelial-mesenchymal transition and tumour invasion. Int J Biochem Cell Biol. 39:2153–2160. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Greenburg G and Hay ED: Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol. 95:333–339. 1982. View Article : Google Scholar : PubMed/NCBI

15 

Thiery JP: Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol. 15:740–746. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Kowalski PJ, Rubin MA and Kleer CG: E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res. 5:R217–R222. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Ngan CY, Yamamoto H, Seshimo I, Tsujino T, Man-i M, Ikeda JI, Konishi K, Takemasa I, Ikeda M, Sekimoto M, et al: Quantitative evaluation of vimentin expression in tumour stroma of colorectal cancer. Br J Cancer. 96:986–992. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Liang J, Zhou H, Peng Y, Xie X, Li R, Liu Y, Xie Q and Lin Z: β-catenin expression negatively correlates with WIF1 and predicts poor clinical outcomes in patients with cervical cancer. Biomed Res Int. 2016:49239032016. View Article : Google Scholar : PubMed/NCBI

19 

Lee MY, Chou CY, Tang MJ and Shen MR: Epithelial-mesenchymal transition in cervical cancer: Correlation with tumor progression, epidermal growth factor receptor overexpression, and snail up-regulation. Clin Cancer Res. 14:4743–4750. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Cheng Y, Zhou Y, Jiang W, Yang X, Zhu J, Feng D, Wei Y, Li M, Yao F, Hu W, et al: Significance of E-cadherin, β-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma. Hum Pathol. 43:1213–1220. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Li XL, Jiang J and Lu SY: Epithelial-mesenchymal transition and gynecologic oncology. Chin J Obstet Gynecol. 47:549–551. 2012.(In Chinese).

22 

Chen X, Bode AM, Dong Z and Cao Y: The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer. FASEB J. 30:3001–3010. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Cyprian FS, Al-Farsi HF, Vranic S, Akhtar S and Al Moustafa AE: Epstein-barr virus and human papillomaviruses interactions and their roles in the initiation of epithelial-mesenchymal transition and cancer progression. Fron Oncol. 8:1112018. View Article : Google Scholar

24 

Lapierre SG, Sauthier P, Mayrand MH, Dufresne S, Petignat P, Provencher D, Drouin P, Gauthier P, Dupuis MJ, Michon B, et al: Human papillomavirus (HPV) DNA triage of women with atypical squamous cells of undetermined significance with cobas 4800 HPV and Hybrid Capture 2 tests for detection of high-grade lesions of the uterine cervix. J Clin Microbiol. 50:1240–1244. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Benedet JL, Bender H, Jones H III, Ngan HY and Pecorelli S: FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO committee on gynecologic oncology. Int J Gynecol Obstet. 70:209–262. 2000. View Article : Google Scholar

26 

Lax SF, Horn LC and Löning T: Categorization of uterine cervix tumors: What's new in the 2014 WHO classification. Pathologe. 37:573–584. 2016.(In German). View Article : Google Scholar : PubMed/NCBI

27 

Isidean SD, Coutlée F and Franco EL: cobas 4800 HPV Test, a real-time polymerase chain reaction assay for the detection of human papillomavirus in cervical specimens. Expert Rev Mol Diagn. 14:5–16. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Jang TJ, Jung KH and Choi EA: Id-1 gene downregulation by sulindac sulfide and its upregulation during tumor development in gastric cancer. Int J Cancer. 118:1356–1363. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Fedchenko N and Reifenrath J: Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue-a review. Diagn Pathol. 9:2212014. View Article : Google Scholar : PubMed/NCBI

30 

Shi D, Jiang K, Fu Y, Fang R, Liu XI and Chen J: Overexpression of SPARC correlates with poor prognosis in patients with cervical carcinoma and regulates cancer cell epithelial-mesenchymal transition. Oncol Lett. 11:3251–3258. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Li B, Shi H, Wang F, Hong D, Lv W, Xie X and Cheng X: Expression of E-, P- and N-cadherin and its clinical significance in cervical squamous cell carcinoma and precancerous lesions. PLoS One. 11:e01559102016. View Article : Google Scholar : PubMed/NCBI

32 

Hazelbag S, Kenter GG, Gorter A, Dreef EJ, Koopman LA, Violette SM, Weinreb PH and Fleuren GJ: Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. J Pathol. 212:316–324. 2007. View Article : Google Scholar : PubMed/NCBI

33 

van Roy F and Berx G: The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci. 65:3756–3788. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Clevers H: Wnt/beta-catenin signaling in development and disease. Cell. 127:469–480. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Stewart CJ and McCluggage WG: Epithelial-mesenchymal transition in carcinomas of the female genital tract. Histopathology. 62:31–43. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Jeanes A, Gottardi CJ and Yap AS: Cadherins and cancer: How does cadherin dysfunction promote tumor progression? Oncogene. 27:6920–6929. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Hazan RB, Qiao R, Keren R, Badano I and Suyama K: Cadherin switch in tumor progression. Ann N Y Acad Sci. 1014:155–163. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Hazan RB, Phillips GR, Qiao RF, Norton L and Aaronson SA: Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol. 148:779–790. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Costa LC, Leite CF, Cardoso SV, Loyola AM, Faria PR, Souza PE and Horta MC: Expression of epithelial-mesenchymal transition markers at the invasive front of oral squamous cell carcinoma. J Appl Oral Sci. 23:169–178. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Nakajima S, Doi R, Toyoda E, Tsuji S, Wada M, Koizumi M, Tulachan SS, Ito D, Kami K, Mori T, et al: N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res. 10:4125–4133. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Sun H, Liu M, Wu X, Yang C, Zhang Y, Xu Z, Gao K and Wang F: Overexpression of N-cadherin and β-catenin correlates with poor prognosis in patients with nasopharyngeal carcinoma. Oncol Lett. 13:1725–1730. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Coulombe PA and Wong P: Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds. Nat Cell Biol. 6:699–706. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Lang SH, Hyde C, Reid IN, Hitchcock IS, Hart CA, Bryden AA, Villette JM, Stower MJ and Maitland NJ: Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma. Prostate. 52:253–263. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Singh S, Sadacharan S, Su S, Belldegrun A, Persad S and Singh G: Overexpression of vimentin: Role in the invasive phenotype in an androgen-independent model of prostate cancer. Cancer Res. 63:2306–2311. 2003.PubMed/NCBI

46 

Liu CY, Lin HH, Tang MJ and Wang YK: Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation. Oncotarget. 6:15966–15983. 2015.PubMed/NCBI

47 

Colomiere M, Findlay J, Ackland L and Ahmed N: Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin. Int J Biochem Cell Biol. 41:1034–1045. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Vora HH, Patel NA, Rajvik KN, Mehta SV, Brahmbhatt BV, Shah MJ, Shukla SN and Shah PM: Cytokeratin and vimentin expression in breast cancer. Int J Biol Markers. 24:38–46. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Shirahata A, Sakata M, Sakuraba K, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y and Hibi K: Vimentin methylation as a marker for advanced colorectal carcinoma. Anticancer Res. 29:279–281. 2009.PubMed/NCBI

50 

Usami Y, Satake S, Nakayama F, Matsumoto M, Ohnuma K, Komori T, Semba S, Ito A and Yokozaki H: Snail-associated epithelial-mesenchymal transition promotes oesophageal squamous cell carcinoma motility and progression. J Pathol. 215:330–339. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Wei J, Xu G, Wu M, Zhang Y, Li Q, Liu P, Zhu T, Song A, Zhao L, Han Z, et al: Overexpression of vimentin contributes to prostate cancer invasion and metastasis via src regulation. Anticancer Res. 28:327–334. 2008.PubMed/NCBI

52 

Pankov R and Yamada KM: Fibronectin at a glance. J Cell Sci. 115:3861–3863. 2002. View Article : Google Scholar : PubMed/NCBI

53 

Birchler MT, Milisavlijevic D, Pfaltz M, Neri D, Odermatt B, Schmid S and Stoeckli SJ: Expression of the extra domain B of fibronectin, a marker of angiogenesis, in head and neck tumors. Laryngoscope. 113:1231–1237. 2003. View Article : Google Scholar : PubMed/NCBI

54 

Huang L, Zheng M, Liu JH, Xiong Y, Ding H, Tang L and Wang HY: Risk factors and prognosis of IB-IIB cervical carcinoma with common iliac lymph node metastasis. Chin J Cancer. 29:431–435. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Li C, Liu W and Cheng Y: Prognostic significance of metastatic lymph node ratio in squamous cell carcinoma of the cervix. Onco Targets Ther. 9:3791–3797. 2016.PubMed/NCBI

56 

Liu Y, Zhao LJ, Li MZ, Li MX, Wang JL and Wei LH: The number of positive pelvic lymph nodes and multiple groups of pelvic lymph node metastasis influence prognosis in stage IA-IIB cervical squamous cell carcinoma. Chin Med J (Engl). 128:2084–2089. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Ajila V, Shetty H, Babu S, Shetty V and Hegde S: Human papilloma virus associated squamous cell carcinoma of the head and neck. J Sex Transm Dis. 2015:7910242015.PubMed/NCBI

58 

Bulk S, Berkhof J, Bulkmans NW, Zielinski GD, Rozendaal L, van Kemenade FJ, Snijders PJ and Meijer CJ: Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands. Br J Cancer. 94:171–175. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Cerasuolo A, Annunziata C, Tortora M, Starita N, Stellato G, Greggi S, Maglione MG, Ionna F, Losito S, Botti G, et al: Comparative analysis of HPV16 gene expression profiles in cervical and in oropharyngeal squamous cell carcinoma. Oncotarget. 8:34070–34081. 2017. View Article : Google Scholar : PubMed/NCBI

60 

Chen W, Zhang X, Molijn A, Jenkins D, Shi JF, Quint W, Schmidt JE, Wang P, Liu YL, Li LK, et al: Human papillomavirus type-distribution in cervical cancer in China: The importance of HPV 16 and 18. Cancer Causes Control. 20:1705–1713. 2009. View Article : Google Scholar : PubMed/NCBI

61 

Laurson J, Khan S, Chung R, Cross K and Raj K: Epigenetic repression of E-cadherin by human papillomavirus 16 E7 protein. Carcinogenesis. 31:918–926. 2010. View Article : Google Scholar : PubMed/NCBI

62 

Cheng YM, Chou CY, Hsu YC, Chen MJ and Wing LY: The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis. Oncol Lett. 3:667–671. 2012. View Article : Google Scholar : PubMed/NCBI

63 

Hellner K, Mar J, Fang F, Quackenbush J and Munger K: HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition. Virology. 391:57–63. 2009. View Article : Google Scholar : PubMed/NCBI

64 

Caberg JH, Hubert PM, Begon DY, Herfs MF, Roncarati PJ, Boniver JJ and Delvenne PO: Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes. Carcinogenesis. 29:1441–1447. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Yang M, Wang M, Li X, Xie Y, Xia X, Tian J, Zhang K and Tang A: Wnt signaling in cervical cancer? J Cancer. 9:1277–1286. 2018. View Article : Google Scholar : PubMed/NCBI

66 

Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR and Lizano M: Regulation of the Wnt/β-catenin signaling pathway by human papillomavirus E6 and E7 oncoproteins. Viruses. 7:4734–4755. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Sominsky S, Kuslansky Y, Shapiro B, Jackman A, Haupt Y, Rosin-Arbesfeld R and Sherman L: HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling. Virology 468–470. 510–523. 2014. View Article : Google Scholar

68 

Ghittoni R, Accardi R, Chiocca S and Tommasino M: Role of human papillomaviruses in carcinogenesis. Ecancermedicalscience. 9:5262015. View Article : Google Scholar : PubMed/NCBI

69 

Yeo-Teh NSL, Ito Y and Jha S: High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis. Int J Mol Sci. 19(pii): E17062018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang J, Li X, Yin X, Zhang J and Shi B: Association of low expression of E‑cadherin and β‑catenin with the progression of early stage human squamous cervical cancer. Oncol Lett 17: 5729-5739, 2019.
APA
Jiang, J., Li, X., Yin, X., Zhang, J., & Shi, B. (2019). Association of low expression of E‑cadherin and β‑catenin with the progression of early stage human squamous cervical cancer. Oncology Letters, 17, 5729-5739. https://doi.org/10.3892/ol.2019.10266
MLA
Jiang, J., Li, X., Yin, X., Zhang, J., Shi, B."Association of low expression of E‑cadherin and β‑catenin with the progression of early stage human squamous cervical cancer". Oncology Letters 17.6 (2019): 5729-5739.
Chicago
Jiang, J., Li, X., Yin, X., Zhang, J., Shi, B."Association of low expression of E‑cadherin and β‑catenin with the progression of early stage human squamous cervical cancer". Oncology Letters 17, no. 6 (2019): 5729-5739. https://doi.org/10.3892/ol.2019.10266
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang J, Li X, Yin X, Zhang J and Shi B: Association of low expression of E‑cadherin and β‑catenin with the progression of early stage human squamous cervical cancer. Oncol Lett 17: 5729-5739, 2019.
APA
Jiang, J., Li, X., Yin, X., Zhang, J., & Shi, B. (2019). Association of low expression of E‑cadherin and β‑catenin with the progression of early stage human squamous cervical cancer. Oncology Letters, 17, 5729-5739. https://doi.org/10.3892/ol.2019.10266
MLA
Jiang, J., Li, X., Yin, X., Zhang, J., Shi, B."Association of low expression of E‑cadherin and β‑catenin with the progression of early stage human squamous cervical cancer". Oncology Letters 17.6 (2019): 5729-5739.
Chicago
Jiang, J., Li, X., Yin, X., Zhang, J., Shi, B."Association of low expression of E‑cadherin and β‑catenin with the progression of early stage human squamous cervical cancer". Oncology Letters 17, no. 6 (2019): 5729-5739. https://doi.org/10.3892/ol.2019.10266
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