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Article

Prognostic profile of patients with non‑viral hepatocellular carcinoma: A comparative study with hepatitis C virus‑related hepatocellular carcinoma using data mining analysis

  • Authors:
    • Yu Noda
    • Takumi Kawaguchi
    • Ryoko Kuromatsu
    • Sho Komukai
    • Masahito Nakano
    • Takashi Niizeki
    • Hironori Koga
    • Atsushi Kawaguchi
    • Takuji Torimura
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565‑0871, Japan, Center for Comprehensive Community Medicine, Faculty of Medicine, Saga University, Saga 849‑0937, Japan
  • Pages: 227-236
    |
    Published online on: April 25, 2019
       https://doi.org/10.3892/ol.2019.10285
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Abstract

Various factors are associated with the prognosis of patients with non‑viral hepatocellular carcinoma (HCC). The present study aimed to investigate the prognosis of patients with non‑viral HCC compared with that of patients with hepatitis C virus‑related (HCV)‑HCC and the features associated with prognosis of patients with non‑viral HCC using data mining analyses. Patients with non‑viral HCC (n=182, age 70.4±8.9 years) and HCV‑HCC (n=612, age 70±8.4 years) were enrolled and the overall survival was compared between the non‑viral HCC and HCV‑HCC groups. The present study performed random forest and decision tree analyses to identify features that distinguish prognosis between the non‑viral HCC and HCV‑HCC groups. The median survival of the non‑viral HCC group was significantly shorter than the HCV‑HCC group (1,553 vs. 2,304 days, P<0.01). In the multivariate analysis, the non‑viral HCC group was an independent risk factor for survival (HR 1.42, 95% CI 1.08‑1.87, P=0.013). In the random forest analysis, the high‑ranking distinguishable factors were ‘number of tumors’ and ‘HCC stage’ in the non‑viral HCC group and ‘albumin’ and ‘total bilirubin’ in the HCV‑HCC group. The decision tree analysis revealed that, in patients with HCC stage >I, the survival period in the non‑viral HCC group was significantly shorter than the HCV‑HCC group (HR 1.39, 95% CI 1.07‑1.81, P=0.0132). The prognosis of patients with non‑viral HCC was poorer than patients with HCV‑HCC. In addition, data mining analysis revealed that tumor‑related variables had the highest importance for survival in patients with non‑viral HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Noda Y, Kawaguchi T, Kuromatsu R, Komukai S, Nakano M, Niizeki T, Koga H, Kawaguchi A and Torimura T: Prognostic profile of patients with non‑viral hepatocellular carcinoma: A comparative study with hepatitis C virus‑related hepatocellular carcinoma using data mining analysis. Oncol Lett 18: 227-236, 2019.
APA
Noda, Y., Kawaguchi, T., Kuromatsu, R., Komukai, S., Nakano, M., Niizeki, T. ... Torimura, T. (2019). Prognostic profile of patients with non‑viral hepatocellular carcinoma: A comparative study with hepatitis C virus‑related hepatocellular carcinoma using data mining analysis. Oncology Letters, 18, 227-236. https://doi.org/10.3892/ol.2019.10285
MLA
Noda, Y., Kawaguchi, T., Kuromatsu, R., Komukai, S., Nakano, M., Niizeki, T., Koga, H., Kawaguchi, A., Torimura, T."Prognostic profile of patients with non‑viral hepatocellular carcinoma: A comparative study with hepatitis C virus‑related hepatocellular carcinoma using data mining analysis". Oncology Letters 18.1 (2019): 227-236.
Chicago
Noda, Y., Kawaguchi, T., Kuromatsu, R., Komukai, S., Nakano, M., Niizeki, T., Koga, H., Kawaguchi, A., Torimura, T."Prognostic profile of patients with non‑viral hepatocellular carcinoma: A comparative study with hepatitis C virus‑related hepatocellular carcinoma using data mining analysis". Oncology Letters 18, no. 1 (2019): 227-236. https://doi.org/10.3892/ol.2019.10285
Copy and paste a formatted citation
x
Spandidos Publications style
Noda Y, Kawaguchi T, Kuromatsu R, Komukai S, Nakano M, Niizeki T, Koga H, Kawaguchi A and Torimura T: Prognostic profile of patients with non‑viral hepatocellular carcinoma: A comparative study with hepatitis C virus‑related hepatocellular carcinoma using data mining analysis. Oncol Lett 18: 227-236, 2019.
APA
Noda, Y., Kawaguchi, T., Kuromatsu, R., Komukai, S., Nakano, M., Niizeki, T. ... Torimura, T. (2019). Prognostic profile of patients with non‑viral hepatocellular carcinoma: A comparative study with hepatitis C virus‑related hepatocellular carcinoma using data mining analysis. Oncology Letters, 18, 227-236. https://doi.org/10.3892/ol.2019.10285
MLA
Noda, Y., Kawaguchi, T., Kuromatsu, R., Komukai, S., Nakano, M., Niizeki, T., Koga, H., Kawaguchi, A., Torimura, T."Prognostic profile of patients with non‑viral hepatocellular carcinoma: A comparative study with hepatitis C virus‑related hepatocellular carcinoma using data mining analysis". Oncology Letters 18.1 (2019): 227-236.
Chicago
Noda, Y., Kawaguchi, T., Kuromatsu, R., Komukai, S., Nakano, M., Niizeki, T., Koga, H., Kawaguchi, A., Torimura, T."Prognostic profile of patients with non‑viral hepatocellular carcinoma: A comparative study with hepatitis C virus‑related hepatocellular carcinoma using data mining analysis". Oncology Letters 18, no. 1 (2019): 227-236. https://doi.org/10.3892/ol.2019.10285
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