Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

HBV upregulates AP‑1 complex subunit mu‑1 expression via the JNK pathway to promote proliferation of liver cancer cells

  • Authors:
    • Yanbo Kou
    • Xiaoqing Yan
    • Qingya Liu
    • Xiao Wei
    • Bo Zhang
    • Xiangyang Li
    • Wei Pan
    • Fanyun Kong
    • Yugang Wang
    • Kuiyang Zheng
    • Renxian Tang
  • View Affiliations / Copyright

    Affiliations: Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Institute of Emergency and Rescue Medicine, Laboratory of Emergency Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China
    Copyright: © Kou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 456-464
    |
    Published online on: April 30, 2019
       https://doi.org/10.3892/ol.2019.10291
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Although hepatitis B virus (HBV) infection is responsible for liver cancer, the exact mechanism of its action remains unclear. μ1 adaptin is an intrinsic part of the clathrin adaptor AP‑1 complex. In addition to its canonical biological function that involves cargo sorting and vesicular transport, recent studies have demonstrated that μ1 adaptin participates in cell growth and proliferation. The aim of the present study was to investigate the effects of the clathrin adaptor AP‑1 complex subunit mu‑1 (AP1M1) on liver cancer cell proliferation. The present study reports for the first time that AP1M1 is upregulated in the HBV‑transfected HepG2.215 liver cancer cells. Silencing of AP1M1 in HepG2.215 cells suppressed their proliferation, while the overexpression of AP1M1 in HepG2 cells promoted cell proliferation. The data suggested that AP1M1 is one of the crucial factors involved in the progression of liver cancer caused by HBV infection. In addition, it was demonstrated that HBV facilitated AP1M1 expression in a JNK‑dependent manner. The increased expression levels of AP1M1 enhanced phosphorylation of protein kinase B and accelerated cell proliferation. Unraveling the effects of AP1M1 on liver cancer cell proliferation and the mechanism of AP1M1 transcriptional regulation may provide new therapeutic targets for HBV‑positive liver cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

El-Serag HB: Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 142:1264–1273. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Kong F, You H, Tang R and Zheng K: The regulation of proteins associated with the cytoskeleton by hepatitis B virus X protein during hepatocarcinogenesis. Oncol Lett. 13:2514–2520. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Lo SJ, Lee Y, Chiou JS, Ting LP, Liu WT and Choo K: Characterization of restriction endonuclease maps of hepatitis B viral DNAs. Biochem Biophys Res Commun. 129:797–803. 1985. View Article : Google Scholar : PubMed/NCBI

4 

Xu W, Yu J and Wong VW: Mechanism and prediction of HCC development in HBV infection. Best Pract Res Clin Gastroenterol. 31:291–298. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Cho HK, Kim SY, Kyaw YY, Win AA, Koo SH, Kim HH and Cheong J: HBx induces the proliferation of hepatocellular carcinoma cells via AP1 over-expressed as a result of ER stress. Biochem J. 466:115–121. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Lin S and Zhang YJ: Interference of Apoptosis by Hepatitis B Virus. Viruses. 9(pii): E2302017.PubMed/NCBI

7 

He Z, Yu Y, Nong Y, Du L, Liu C, Cao Y, Bai L and Tang H: Hepatitis B virus X protein promotes hepatocellular carcinoma invasion and metastasis via upregulating thioredoxin interacting protein. Oncol Lett. 14:1323–1332. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Geng M, Xin X, Bi LQ, Zhou LT and Liu XH: Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis. World J Gastroenterol. 21:10732–10738. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Yang ST, Yen CJ, Lai CH, Lin YJ, Chang KC, Lee JC, Liu YW, Chang-Liao PY, Hsu LS, Chang WC, et al: SUMOylated CPAP is required for IKK-mediated NF-κB activation and enhances HBx-induced NF-κB signaling in HCC. J Hepatol. 58:1157–1164. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Zhang F, Wang Q, Ye L, Feng Y and Zhang X: Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol. 82:920–928. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Doria M, Klein N, Lucito R and Schneider RJ: The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J. 14:4747–4757. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Klein NP and Schneider RJ: Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol Cell Biol. 17:6427–6436. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Schmid SL: Clathrin-coated vesicle formation and protein sorting: An integrated process. Annu Rev Biochem. 66:511–548. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Doray B and Kornfeld S: Gamma subunit of the AP-1 adaptor complex binds clathrin: Implications for cooperative binding in coated vesicle assembly. Mol Biol Cell. 12:1925–1935. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Ohno H, Tomemori T, Nakatsu F, Okazaki Y, Aguilar RC, Foelsch H, Mellman I, Saito T, Shirasawa T and Bonifacino JS: Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett. 449:215–220. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Navarro Negredo P, Edgar JR, Wrobel AG, Zaccai NR, Antrobus R, Owen DJ and Robinson MS: Contribution of the clathrin adaptor AP-1 subunit μ1 to acidic cluster protein sorting. J Cell Biol. 216:2927–2943. 2017.PubMed/NCBI

17 

Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T and Bonifacino JS: Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science. 269:1872–1875. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Mukherjee D, Hanna CB and Aguilar RC: Artificial neural network for the prediction of tyrosine-based sorting signal recognition by adaptor complexes. J Biomed Biotechnol. 2012:4980312012. View Article : Google Scholar : PubMed/NCBI

19 

Tavares LA, da Silva EM, da Silva-Januário ME, Januário YC, de Cavalho JV, Czernisz ÉS, Mardones GA and daSilva LL: CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the γ1 and γ2 subunits of the AP-1 complex in protein trafficking. J Cell Sci. 130:429–443. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Park M, Song K, Reichardt I, Kim H, Mayer U, Stierhof YD, Hwang I and Jürgens G: Arabidopsis µ-adaptin subunit AP1M of adaptor protein complex 1 mediates late secretory and vacuolar traffic and is required for growth. Proc Natl Acad Sci USA. 110:10318–10323. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Yoneyama Y, Matsuo M, Take K, Kabuta T, Chida K, Hakuno F and Takahashi S: The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation. Mol Cell Biol. 33:1991–2003. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Hase K, Nakatsu F, Ohmae M, Sugihara K, Shioda N, Takahashi D, Obata Y, Furusawa Y, Fujimura Y, Yamashita T, et al: AP-1B mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice. Gastroenterology. 145:625–635. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Kong F, Hu W, Zhou K, Wei X, Kou Y, You H, Zheng K and Tang R: Hepatitis B virus X protein promotes interleukin-7 receptor expression via NF-κB and Notch1 pathway to facilitate proliferation and migration of hepatitis B virus-related hepatoma cells. J Exp Clin Cancer Res. 35:1722016. View Article : Google Scholar : PubMed/NCBI

24 

Tang R, Kong F, Hu L, You H, Zhang P, Du W and Zheng K: Role of hepatitis B virus X protein in regulating LIM and SH3 protein 1 (LASP-1) expression to mediate proliferation and migration of hepatoma cells. Virol J. 9:1632012. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Nissim O, Melis M, Diaz G, Kleiner DE, Tice A, Fantola G, Zamboni F, Mishra L and Farci P: Liver regeneration signature in hepatitis B virus (HBV)-associated acute liver failure identified by gene expression profiling. PLoS One. 7:e496112012. View Article : Google Scholar : PubMed/NCBI

27 

Hayashi S, Khan A, Simons BC, Homan C, Matsui T, Ogawa K, Kawashima K, Murakami S, Takahashi S, Isogawa M, et al: A novel association between core mutations in hepatitis B virus genotype F1b and hepatocellular carcinoma in Alaskan Native People. Hepatology. 69:19–33. 2019.PubMed/NCBI

28 

Waziry R, Grebely J, Amin J, Alavi M, Hajarizadeh B, George J, Matthews GV, Law M and Dore GJ: Survival following hospitalization with hepatocellular carcinoma among people notified with hepatitis B or C virus in Australia (2000–2014). Hepatol Commun. 1:736–747. 2017. View Article : Google Scholar : PubMed/NCBI

29 

You H, Kong F, Zhou K, Wei X, Hu L, Hu W, Luo W, Kou Y, Liu X, Chen X, et al: HBX protein promotes LASP-1 expression through activation of c-Jun in human hepatoma cells. J Cell Physiol. 233:7279–7291. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Kong F, You H, Zhao J, Liu W, Hu L, Luo W, Hu W, Tang R and Zheng K: The enhanced expression of death receptor 5 (DR5) mediated by HBV X protein through NF-kappaB pathway is associated with cell apoptosis induced by (TNF-α related apoptosis inducing ligand) TRAIL in hepatoma cells. Virol J. 12:1922015. View Article : Google Scholar : PubMed/NCBI

31 

Bak Y, Shin HJ, Bak IS, Yoon DY and Yu DY: Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway. Biochem Biophys Res Commun. 466:676–681. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Kim SY, Kim JC, Kim JK, Kim HJ, Lee HM, Choi MS, Maeng PJ and Ahn JK: Hepatitis B virus X protein enhances NFkappaB activity through cooperating with VBP1. BMB Rep. 41:158–163. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Zheng BY, Gao WY, Huang XY, Lin LY, Fang XF, Chen ZX and Wang XZ: HBx promotes the proliferative ability of HL-7702 cells via the COX-2/Wnt/β-catenin pathway. Mol Med Rep. 17:8432–8438. 2018.PubMed/NCBI

34 

Kongkavitoon P, Tangkijvanich P, Hirankarn N and Palaga T: Hepatitis B virus HBx activates notch signaling via Delta-Like 4/Notch1 in hepatocellular carcinoma. PLoS One. 11:e01466962016. View Article : Google Scholar : PubMed/NCBI

35 

Kang-Park S, Lee JH, Shin JH and Lee YI: Activation of the IGF-II gene by HBV–X protein requires PKC and p44/p42 map kinase signalings. Biochem Biophys Res Commun. 283:303–307. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Boehm M and Bonifacino JS: Genetic analyses of adaptin function from yeast to mammals. Gene. 286:175–186. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Robinson DG and Pimpl P: Clathrin and post-Golgi trafficking: A very complicated issue. Trends Plant Sci. 19:134–139. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Robinson MS: Forty years of Clathrin-coated vesicles. Traffic. 16:1210–1238. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Zheng X, Chang RL, Cui XX, Avila G, Huang MT, Liu Y, Kong AN, Rabson AB and Conney AH: Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells. Int J Oncol. 32:257–264. 2008.PubMed/NCBI

40 

Bakhtiari E, Hosseini A, Boroushaki MT and Mousavi SH: Angiotensin II receptor antagonist olmesartan and NF-kappaB inhibitor as cytotoxic and apoptotic agents in MCF-7 human cell line. J Chemother. 28:314–320. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Uluçkan Ö, Guinea-Viniegra J, Jimenez M and Wagner EF: Signalling in inflammatory skin disease by AP-1 (Fos/Jun). Clin Exp Rheumatol 33 (4 Suppl 92). S44–S49. 2015.

42 

Benn J, Su F, Doria M and Schneider RJ: Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. J Virol. 70:4978–4985. 1996.PubMed/NCBI

43 

Natoli G, Avantaggiati ML, Chirillo P, Costanzo A, Artini M, Balsano C and Levrero M: Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX. Mol Cell Biol. 12:989–998. 1994. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kou Y, Yan X, Liu Q, Wei X, Zhang B, Li X, Pan W, Kong F, Wang Y, Zheng K, Zheng K, et al: HBV upregulates AP‑1 complex subunit mu‑1 expression via the JNK pathway to promote proliferation of liver cancer cells. Oncol Lett 18: 456-464, 2019.
APA
Kou, Y., Yan, X., Liu, Q., Wei, X., Zhang, B., Li, X. ... Tang, R. (2019). HBV upregulates AP‑1 complex subunit mu‑1 expression via the JNK pathway to promote proliferation of liver cancer cells. Oncology Letters, 18, 456-464. https://doi.org/10.3892/ol.2019.10291
MLA
Kou, Y., Yan, X., Liu, Q., Wei, X., Zhang, B., Li, X., Pan, W., Kong, F., Wang, Y., Zheng, K., Tang, R."HBV upregulates AP‑1 complex subunit mu‑1 expression via the JNK pathway to promote proliferation of liver cancer cells". Oncology Letters 18.1 (2019): 456-464.
Chicago
Kou, Y., Yan, X., Liu, Q., Wei, X., Zhang, B., Li, X., Pan, W., Kong, F., Wang, Y., Zheng, K., Tang, R."HBV upregulates AP‑1 complex subunit mu‑1 expression via the JNK pathway to promote proliferation of liver cancer cells". Oncology Letters 18, no. 1 (2019): 456-464. https://doi.org/10.3892/ol.2019.10291
Copy and paste a formatted citation
x
Spandidos Publications style
Kou Y, Yan X, Liu Q, Wei X, Zhang B, Li X, Pan W, Kong F, Wang Y, Zheng K, Zheng K, et al: HBV upregulates AP‑1 complex subunit mu‑1 expression via the JNK pathway to promote proliferation of liver cancer cells. Oncol Lett 18: 456-464, 2019.
APA
Kou, Y., Yan, X., Liu, Q., Wei, X., Zhang, B., Li, X. ... Tang, R. (2019). HBV upregulates AP‑1 complex subunit mu‑1 expression via the JNK pathway to promote proliferation of liver cancer cells. Oncology Letters, 18, 456-464. https://doi.org/10.3892/ol.2019.10291
MLA
Kou, Y., Yan, X., Liu, Q., Wei, X., Zhang, B., Li, X., Pan, W., Kong, F., Wang, Y., Zheng, K., Tang, R."HBV upregulates AP‑1 complex subunit mu‑1 expression via the JNK pathway to promote proliferation of liver cancer cells". Oncology Letters 18.1 (2019): 456-464.
Chicago
Kou, Y., Yan, X., Liu, Q., Wei, X., Zhang, B., Li, X., Pan, W., Kong, F., Wang, Y., Zheng, K., Tang, R."HBV upregulates AP‑1 complex subunit mu‑1 expression via the JNK pathway to promote proliferation of liver cancer cells". Oncology Letters 18, no. 1 (2019): 456-464. https://doi.org/10.3892/ol.2019.10291
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team