Incidence and significance of psammoma bodies in Xp11.2 translocation renal cell carcinoma and papillary renal cell carcinoma

  • Authors:
    • Ning Liu
    • Feng Qu
    • Kang Wei
    • Weidong Gan
    • Zhen Wang
    • Wenyuan Zhuang
    • Sezim Agizamhan
    • Wenliang Ma
    • Jun Yang
    • Ming Chen
    • Linfeng Xu
    • Hongqian Guo
    • Dongmei Li
  • View Affiliations

  • Published online on: May 3, 2019     https://doi.org/10.3892/ol.2019.10305
  • Pages: 472-478
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Abstract

The aim of the present study was to investigate the incidence and significance of psammoma bodies (PBs) in Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) and papillary renal cell carcinoma (PRCC). The presence of PBs, irregular calcifications, hyaline globules and nested architecture in RCC tissues, which included 47 cases of Xp11.2 tRCC and 95 cases of PRCC, was examined by two pathologists. Compared with PRCC, patients with Xp11.2 tRCC exhibited a higher frequency of PBs, hyaline globules and nested architecture. The presence of PBs in combination with the occurrence of a nested architecture achieved a specificity of 93.7% when diagnosing Xp11.2 tRCC. However, there were no significant differences in the overall survival between patients with and without PBs in both types of RCC. Therefore, the presence of PBs combined with nested architecture may provide guidance for the diagnosis of Xp11.2 tRCC; however, PBs cannot predict tumor behavior in Xp11.2 tRCC or PRCC.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu N, Qu F, Wei K, Gan W, Wang Z, Zhuang W, Agizamhan S, Ma W, Yang J, Chen M, Chen M, et al: Incidence and significance of psammoma bodies in Xp11.2 translocation renal cell carcinoma and papillary renal cell carcinoma. Oncol Lett 18: 472-478, 2019
APA
Liu, N., Qu, F., Wei, K., Gan, W., Wang, Z., Zhuang, W. ... Li, D. (2019). Incidence and significance of psammoma bodies in Xp11.2 translocation renal cell carcinoma and papillary renal cell carcinoma. Oncology Letters, 18, 472-478. https://doi.org/10.3892/ol.2019.10305
MLA
Liu, N., Qu, F., Wei, K., Gan, W., Wang, Z., Zhuang, W., Agizamhan, S., Ma, W., Yang, J., Chen, M., Xu, L., Guo, H., Li, D."Incidence and significance of psammoma bodies in Xp11.2 translocation renal cell carcinoma and papillary renal cell carcinoma". Oncology Letters 18.1 (2019): 472-478.
Chicago
Liu, N., Qu, F., Wei, K., Gan, W., Wang, Z., Zhuang, W., Agizamhan, S., Ma, W., Yang, J., Chen, M., Xu, L., Guo, H., Li, D."Incidence and significance of psammoma bodies in Xp11.2 translocation renal cell carcinoma and papillary renal cell carcinoma". Oncology Letters 18, no. 1 (2019): 472-478. https://doi.org/10.3892/ol.2019.10305