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Aberrant histone deacetylase 1 expression upregulates vimentin expression via an NF‑κB‑dependent pathway in hepatocellular carcinoma

  • Authors:
    • Huancheng Zhou
    • Jiwei Xu
    • Caiyun Zhang
    • Yuanzhang Wen
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Meizhou People's Hospital, Meizhou, Guangdong 514031, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 339-347
    |
    Published online on: May 3, 2019
       https://doi.org/10.3892/ol.2019.10309
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Abstract

Aberrantly elevated expression levels of histone deacetylase 1 (HDAC1) and vimentin are closely associated with disease progression in hepatocellular carcinoma (HCC). It was previously demonstrated that knocking down expression of HDAC1 resulted in a concurrent decrease in the expression levels of vimentin. However, a causal link between these two proteins has not yet been demonstrated, to the best of our knowledge. In the present study, the association between HDAC1 and vimentin was investigated using an HDAC1 overexpression platform. HDAC1 and vimentin were significantly increased in HCC cells, and HDAC1 overexpression enhanced vimentin mRNA and protein expression levels in an HDAC1 dose‑dependent manner. Subsequently, truncation and mutation of a vimentin promoter demonstrated that HDAC1‑induced vimentin expression was dependent on a nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB) binding site in the vimentin promoter sequence. Furthermore, HDAC1 induced vimentin expression by promoting NF‑κB translocation between the cytoplasm and the nucleus, as opposed to modulating the total expression level of vimentin directly. The data in the present study demonstrated that HDAC1 is overexpressed in HCC and that HDAC1 may upregulate vimentin expression through the NF‑κB signaling pathway, thus demonstrating a causal link between HDAC1 and vimentin in HCC, and may provide valuable information in understanding the pathogenesis of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Xu J, Zhang C and Wen Y: Aberrant histone deacetylase 1 expression upregulates vimentin expression via an NF‑κB‑dependent pathway in hepatocellular carcinoma. Oncol Lett 18: 339-347, 2019.
APA
Zhou, H., Xu, J., Zhang, C., & Wen, Y. (2019). Aberrant histone deacetylase 1 expression upregulates vimentin expression via an NF‑κB‑dependent pathway in hepatocellular carcinoma. Oncology Letters, 18, 339-347. https://doi.org/10.3892/ol.2019.10309
MLA
Zhou, H., Xu, J., Zhang, C., Wen, Y."Aberrant histone deacetylase 1 expression upregulates vimentin expression via an NF‑κB‑dependent pathway in hepatocellular carcinoma". Oncology Letters 18.1 (2019): 339-347.
Chicago
Zhou, H., Xu, J., Zhang, C., Wen, Y."Aberrant histone deacetylase 1 expression upregulates vimentin expression via an NF‑κB‑dependent pathway in hepatocellular carcinoma". Oncology Letters 18, no. 1 (2019): 339-347. https://doi.org/10.3892/ol.2019.10309
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Xu J, Zhang C and Wen Y: Aberrant histone deacetylase 1 expression upregulates vimentin expression via an NF‑κB‑dependent pathway in hepatocellular carcinoma. Oncol Lett 18: 339-347, 2019.
APA
Zhou, H., Xu, J., Zhang, C., & Wen, Y. (2019). Aberrant histone deacetylase 1 expression upregulates vimentin expression via an NF‑κB‑dependent pathway in hepatocellular carcinoma. Oncology Letters, 18, 339-347. https://doi.org/10.3892/ol.2019.10309
MLA
Zhou, H., Xu, J., Zhang, C., Wen, Y."Aberrant histone deacetylase 1 expression upregulates vimentin expression via an NF‑κB‑dependent pathway in hepatocellular carcinoma". Oncology Letters 18.1 (2019): 339-347.
Chicago
Zhou, H., Xu, J., Zhang, C., Wen, Y."Aberrant histone deacetylase 1 expression upregulates vimentin expression via an NF‑κB‑dependent pathway in hepatocellular carcinoma". Oncology Letters 18, no. 1 (2019): 339-347. https://doi.org/10.3892/ol.2019.10309
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