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Article

Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells

Corrigendum in: /10.3892/ol.2023.14084
  • Authors:
    • Hao Wang
    • Chun‑Hua Chi
    • Ying Zhang
    • Bin Shi
    • Ru Jia
    • Ben‑Jun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China, Department of Anorectal Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China, Anorectal Department of Traditional Chinese Medicine, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China, Department of Anorectal Surgery, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230001, P.R. China
  • Pages: 63-71
    |
    Published online on: May 6, 2019
       https://doi.org/10.3892/ol.2019.10319
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Abstract

Histone deacetylase (HDAC) inhibitors and DNA alkylators are effective components used in combination chemotherapy. In the present study, the effects of HDAC inhibitors on the expression of ATP‑binding cassette (ABC) transporters were investigated. It was observed that HDAC inhibitors induced the expression of multidrug‑resistant ABC transporters differently in lung cancer A549 cells than in colorectal cancer HCT116 cells. In these two cell lines, the HDAC inhibitors suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA) significantly increased ABCB1 expression at the mRNA and protein levels, whereas they had no evident effect on ABCG2 protein expression. SAHA and TSA decreased ABCG2 mRNA expression in A549 cells and had no evident effect on ABCG2 mRNA expression in HCT116 cells. Notably, SAHA and TSA increased the mRNA expression levels of ABCC5, ABCC6, ABCC10, ABCC11 and ABCC12, as well as the protein expression levels of ABCC2, ABCC10 and ABCC12. By contrast, these inhibitors decreased the mRNA expression levels of ABCC1, ABCC2, ABCC3 and ABCC4, as well as the expression of ABCC1 and ABCC3 proteins. Furthermore, SAHA and TSA were found to downregulate HDAC3 and HDAC4, but not HDAC1 and HDAC2. Taken together, the results suggested that HDAC inhibitors work synergistically with DNA alkylators, in part, due to the inhibitory effect of these inhibitors on ABCC1 expression, which translocates these alkylators from inside to outside of cancer cells. These results further suggested the possibility of antagonism when HDAC inhibitors are combined with anthracyclines and other ABCB1 drug ligands in chemotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Chi CH, Zhang Y, Shi B, Jia R and Wang BJ: Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells Corrigendum in /10.3892/ol.2023.14084. Oncol Lett 18: 63-71, 2019.
APA
Wang, H., Chi, C., Zhang, Y., Shi, B., Jia, R., & Wang, B. (2019). Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells Corrigendum in /10.3892/ol.2023.14084. Oncology Letters, 18, 63-71. https://doi.org/10.3892/ol.2019.10319
MLA
Wang, H., Chi, C., Zhang, Y., Shi, B., Jia, R., Wang, B."Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells Corrigendum in /10.3892/ol.2023.14084". Oncology Letters 18.1 (2019): 63-71.
Chicago
Wang, H., Chi, C., Zhang, Y., Shi, B., Jia, R., Wang, B."Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells Corrigendum in /10.3892/ol.2023.14084". Oncology Letters 18, no. 1 (2019): 63-71. https://doi.org/10.3892/ol.2019.10319
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Chi CH, Zhang Y, Shi B, Jia R and Wang BJ: Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells Corrigendum in /10.3892/ol.2023.14084. Oncol Lett 18: 63-71, 2019.
APA
Wang, H., Chi, C., Zhang, Y., Shi, B., Jia, R., & Wang, B. (2019). Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells Corrigendum in /10.3892/ol.2023.14084. Oncology Letters, 18, 63-71. https://doi.org/10.3892/ol.2019.10319
MLA
Wang, H., Chi, C., Zhang, Y., Shi, B., Jia, R., Wang, B."Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells Corrigendum in /10.3892/ol.2023.14084". Oncology Letters 18.1 (2019): 63-71.
Chicago
Wang, H., Chi, C., Zhang, Y., Shi, B., Jia, R., Wang, B."Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells Corrigendum in /10.3892/ol.2023.14084". Oncology Letters 18, no. 1 (2019): 63-71. https://doi.org/10.3892/ol.2019.10319
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