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Article Open Access

LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection

  • Authors:
    • Weirong Xiao
    • Aiwan Yin
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410000, P.R. China, Department of Traditional Chinese Medicine, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410000, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 101-108
    |
    Published online on: May 6, 2019
       https://doi.org/10.3892/ol.2019.10322
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Abstract

Melanoma is a rare malignancy in China and the treatment outcomes are generally satisfactory. However, postoperative recurrence can be life‑threatening. The current study aimed to investigate the involvement of long intergenic non‑protein coding RNA 1638 (LINC01638) long non‑coding RNA (lncRNA) in the recurrence of melanoma. Expression of LINC01638 lncRNA in skin biopsies and plasma of patients with melanoma, patients with benign skin lesions and healthy controls was detected by reverse transcription‑quantitative polymerase chain reaction. Diagnostic values of LINC01638 lncRNA for melanoma were analyzed by receiver operating characteristic curve analysis. The association between LINC01638 lncRNA and clinicopathological data of patients with melanoma was analyzed by χ2 test. All patients were followed up for five years to record recurrence. LINC01638 lncRNA expression vectors and shRNAs were transfected into human melanoma cell lines and the effects of LINC01638 lncRNA overexpression and knockdown on cell proliferation were analyzed by cell counting kit‑8 assay. LINC01638 lncRNA was significantly upregulated in patients with melanoma compared with the other two groups of patients, and upregulation of LINC01638 lncRNA distinguished patients with melanoma from patients with benign skin lesions and healthy controls. LINC01638 lncRNA expression was significantly associated with tumor size but not with other patient clinical data. Plasma levels of LINC01638 lncRNA were further increased during follow‑up in patients with local recurrence but not in patients without recurrence. LINC01638 lncRNA overexpression promoted, while knockdown inhibited proliferation of cells of melanoma cell lines, C32 and SK‑MEL‑28, in vitro. The upregulation of LINC01638 lncRNA was likely associated with the local recurrence of melanoma following surgical resection.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao W and Yin A: LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection. Oncol Lett 18: 101-108, 2019.
APA
Xiao, W., & Yin, A. (2019). LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection. Oncology Letters, 18, 101-108. https://doi.org/10.3892/ol.2019.10322
MLA
Xiao, W., Yin, A."LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection". Oncology Letters 18.1 (2019): 101-108.
Chicago
Xiao, W., Yin, A."LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection". Oncology Letters 18, no. 1 (2019): 101-108. https://doi.org/10.3892/ol.2019.10322
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao W and Yin A: LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection. Oncol Lett 18: 101-108, 2019.
APA
Xiao, W., & Yin, A. (2019). LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection. Oncology Letters, 18, 101-108. https://doi.org/10.3892/ol.2019.10322
MLA
Xiao, W., Yin, A."LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection". Oncology Letters 18.1 (2019): 101-108.
Chicago
Xiao, W., Yin, A."LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection". Oncology Letters 18, no. 1 (2019): 101-108. https://doi.org/10.3892/ol.2019.10322
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