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Article

Clinical effectiveness of combined interventional therapy as a salvage modality for unresectable pancreatic carcinoma

  • Authors:
    • Sushant Kumar Das
    • Jin Liang Wang
    • Bing Li
    • Chuan Zhang
    • Han Feng Yang
  • View Affiliations / Copyright

    Affiliations: Department of Interventional Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Department of Radiology, Pingdingshan Fifth People's Hospital, Pingdingshan, Henan 467000, P.R. China
  • Pages: 375-385
    |
    Published online on: May 6, 2019
       https://doi.org/10.3892/ol.2019.10323
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Abstract

Although different treatment methods have been introduced to treat advanced pancreatic carcinoma, the median overall survival rate remains unsatisfactory. Theoretically, combining different treatment methods should work in synergy to enhance locoregional disease control and improve survival. Therefore, the aim of the present retrospective study was to analyze the effectiveness of combined interventional therapy compared with trans‑arterial chemoembolization (TACE) or chemotherapy alone for the treatment of unresectable pancreatic carcinoma. A total of 266 patients who were undergoing treatment for unresectable pancreatic carcinoma between July 2012 and November 2015 were included in the current study. The tumor responses and 3‑year overall survival rates of patients treated with combined interventional therapy (TACE combined with iodine‑125 seed implantation and/or radiofrequency ablation; CIT group; n=84) were compared with those of patients treated with TACE alone (TACE group; n=59), as well as patients treated with systemic chemotherapy alone (control group; n=123). Patients in the CIT group exhibited significantly improved tumor responses compared with patients in the TACE group (51.89 vs. 30.61%; P=0.028) or control group (51.89 vs. 17.20%; P<0.001). The 3‑year overall survival rate of the CIT group was also significantly higher compared with that of the TACE and control groups (P=0.0116 and P=0.0001, respectively). Furthermore, the CIT group exhibited a significantly higher overall survival rate for patients with unresectable metastatic pancreatic cancer compared with the TACE and control groups (P=0.0088 and P<0.0001, respectively), which suggests that a combination of different interventional techniques increases the survival of patients with unresectable pancreatic cancer. No life‑threatening complications were observed in any treatment group. In conclusion, combined interventional therapy exhibits a good efficacy and an improved survival rate for unresectable pancreatic cancer compared with TACE alone.
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Copy and paste a formatted citation
Spandidos Publications style
Das SK, Wang JL, Li B, Zhang C and Yang HF: Clinical effectiveness of combined interventional therapy as a salvage modality for unresectable pancreatic carcinoma. Oncol Lett 18: 375-385, 2019.
APA
Das, S.K., Wang, J.L., Li, B., Zhang, C., & Yang, H.F. (2019). Clinical effectiveness of combined interventional therapy as a salvage modality for unresectable pancreatic carcinoma. Oncology Letters, 18, 375-385. https://doi.org/10.3892/ol.2019.10323
MLA
Das, S. K., Wang, J. L., Li, B., Zhang, C., Yang, H. F."Clinical effectiveness of combined interventional therapy as a salvage modality for unresectable pancreatic carcinoma". Oncology Letters 18.1 (2019): 375-385.
Chicago
Das, S. K., Wang, J. L., Li, B., Zhang, C., Yang, H. F."Clinical effectiveness of combined interventional therapy as a salvage modality for unresectable pancreatic carcinoma". Oncology Letters 18, no. 1 (2019): 375-385. https://doi.org/10.3892/ol.2019.10323
Copy and paste a formatted citation
x
Spandidos Publications style
Das SK, Wang JL, Li B, Zhang C and Yang HF: Clinical effectiveness of combined interventional therapy as a salvage modality for unresectable pancreatic carcinoma. Oncol Lett 18: 375-385, 2019.
APA
Das, S.K., Wang, J.L., Li, B., Zhang, C., & Yang, H.F. (2019). Clinical effectiveness of combined interventional therapy as a salvage modality for unresectable pancreatic carcinoma. Oncology Letters, 18, 375-385. https://doi.org/10.3892/ol.2019.10323
MLA
Das, S. K., Wang, J. L., Li, B., Zhang, C., Yang, H. F."Clinical effectiveness of combined interventional therapy as a salvage modality for unresectable pancreatic carcinoma". Oncology Letters 18.1 (2019): 375-385.
Chicago
Das, S. K., Wang, J. L., Li, B., Zhang, C., Yang, H. F."Clinical effectiveness of combined interventional therapy as a salvage modality for unresectable pancreatic carcinoma". Oncology Letters 18, no. 1 (2019): 375-385. https://doi.org/10.3892/ol.2019.10323
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