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Article

Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years

  • Authors:
    • Jie Xu
    • Lu Xie
    • Xin Sun
    • Sen Dong
    • Xiaodong Tang
    • Wei Guo
  • View Affiliations / Copyright

    Affiliations: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing 100034, P.R. China
  • Pages: 348-358
    |
    Published online on: May 7, 2019
       https://doi.org/10.3892/ol.2019.10328
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Abstract

The aim of the present study was to evaluate the antitumor activity of drugs in phase II clinical trials for recurrent or refractory EWS. A systematic review was performed using clinical trials from four data sources: i) ClinicalTrials.gov; ii) PubMed; iii) Clinicaltrialsregister.eu; and iv) American Society of Clinical Oncology. The search terms included: ‘(Ewing sarcoma OR Ewing family of tumors) AND (phase II OR phase I/II)’. Overall, 465 trials were identified and 64 were included in the present study, of which, 37 had published results. The highest objective response rate came from irinotecan‑based chemotherapy. Currently, the majority of targeted therapy has failed to demonstrate any activity except for regorafenib. Trials using anti‑angiogenesis small molecular tyrosine kinase inhibitors (aaTKIs) are currently ongoing with promising early results. For immunotherapy, anti‑insulin like growth factor 1 receptor antibody demonstrated disappointing activity. The best outcome came from irinotecan‑based regimens. Targeted therapy with aaTKIs is worthy of further investigation, with immunotherapy is not recommended for off‑label use.
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Copy and paste a formatted citation
Spandidos Publications style
Xu J, Xie L, Sun X, Dong S, Tang X and Guo W: Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years. Oncol Lett 18: 348-358, 2019.
APA
Xu, J., Xie, L., Sun, X., Dong, S., Tang, X., & Guo, W. (2019). Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years. Oncology Letters, 18, 348-358. https://doi.org/10.3892/ol.2019.10328
MLA
Xu, J., Xie, L., Sun, X., Dong, S., Tang, X., Guo, W."Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years". Oncology Letters 18.1 (2019): 348-358.
Chicago
Xu, J., Xie, L., Sun, X., Dong, S., Tang, X., Guo, W."Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years". Oncology Letters 18, no. 1 (2019): 348-358. https://doi.org/10.3892/ol.2019.10328
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Xie L, Sun X, Dong S, Tang X and Guo W: Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years. Oncol Lett 18: 348-358, 2019.
APA
Xu, J., Xie, L., Sun, X., Dong, S., Tang, X., & Guo, W. (2019). Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years. Oncology Letters, 18, 348-358. https://doi.org/10.3892/ol.2019.10328
MLA
Xu, J., Xie, L., Sun, X., Dong, S., Tang, X., Guo, W."Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years". Oncology Letters 18.1 (2019): 348-358.
Chicago
Xu, J., Xie, L., Sun, X., Dong, S., Tang, X., Guo, W."Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years". Oncology Letters 18, no. 1 (2019): 348-358. https://doi.org/10.3892/ol.2019.10328
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