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Article

Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218

  • Authors:
    • Xuezhi Tong
    • Pei Yang
    • Kuanyu Wang
    • Yanwei Liu
    • Xiu Liu
    • Xia Shan
    • Ruoyu Huang
    • Ke'nan Zhang
    • Jiangfei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Beijing Tiantan Hospital, Beijing 100050, P.R. China, Department of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, P.R. China
  • Pages: 359-367
    |
    Published online on: May 7, 2019
       https://doi.org/10.3892/ol.2019.10335
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Abstract

Accumulating evidence has revealed that survivin expression is associated with a malignant phenotype and poor prognosis in glioma. Survivin is also a potential target of microRNA (miRNA/miR)‑218. The aim of the present study was to investigate the expression and function of survivin in glioblastoma, and to examine the association between survivin and miR‑218. For that purpose, survivin mRNA levels were analyzed in 144 frozen samples of glioblastoma using whole‑genome RNA sequencing. In vitro cell proliferation, migration, invasion and apoptosis assays were performed, and survivin expression was detected by western blotting. The results revealed that the mRNA expression levels of survivin were negatively and significantly associated with overall survival in glioblastoma. Further in vitro analyses suggested that miR‑218 may inhibit the expression of survivin. Expression of miR‑218 in the LN229 cell line was significantly lower than that in the immortalized human gliocyte HEB cell line. miR‑218 markedly inhibited tumor cell proliferation, migration and invasion capacities, and decreased apoptosis. miR‑218 also inhibited the expression of survivin. These results indicated that survivin may be a target of miR‑218 and could serve as a predictive biomarker.
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Copy and paste a formatted citation
Spandidos Publications style
Tong X, Yang P, Wang K, Liu Y, Liu X, Shan X, Huang R, Zhang K and Wang J: Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218. Oncol Lett 18: 359-367, 2019.
APA
Tong, X., Yang, P., Wang, K., Liu, Y., Liu, X., Shan, X. ... Wang, J. (2019). Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218. Oncology Letters, 18, 359-367. https://doi.org/10.3892/ol.2019.10335
MLA
Tong, X., Yang, P., Wang, K., Liu, Y., Liu, X., Shan, X., Huang, R., Zhang, K., Wang, J."Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218". Oncology Letters 18.1 (2019): 359-367.
Chicago
Tong, X., Yang, P., Wang, K., Liu, Y., Liu, X., Shan, X., Huang, R., Zhang, K., Wang, J."Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218". Oncology Letters 18, no. 1 (2019): 359-367. https://doi.org/10.3892/ol.2019.10335
Copy and paste a formatted citation
x
Spandidos Publications style
Tong X, Yang P, Wang K, Liu Y, Liu X, Shan X, Huang R, Zhang K and Wang J: Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218. Oncol Lett 18: 359-367, 2019.
APA
Tong, X., Yang, P., Wang, K., Liu, Y., Liu, X., Shan, X. ... Wang, J. (2019). Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218. Oncology Letters, 18, 359-367. https://doi.org/10.3892/ol.2019.10335
MLA
Tong, X., Yang, P., Wang, K., Liu, Y., Liu, X., Shan, X., Huang, R., Zhang, K., Wang, J."Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218". Oncology Letters 18.1 (2019): 359-367.
Chicago
Tong, X., Yang, P., Wang, K., Liu, Y., Liu, X., Shan, X., Huang, R., Zhang, K., Wang, J."Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218". Oncology Letters 18, no. 1 (2019): 359-367. https://doi.org/10.3892/ol.2019.10335
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