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Article Open Access

High‑resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia

Corrigendum in: /10.3892/ol.2019.10582
  • Authors:
    • Min Jiang
    • Jie Li
    • Jun Zhou
    • Chao Xing
    • Jing‑Jing Xu
    • Feng Guo
  • View Affiliations / Copyright

    Affiliations: Department of Blood Transfusion, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Special Requirements Ward, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Center for Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Laboratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215001, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 814-821
    |
    Published online on: May 13, 2019
       https://doi.org/10.3892/ol.2019.10342
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Abstract

High resolution melting (HRM) assay is a novel technology for the fast, high‑throughput, sensitive, post‑PCR analysis of genetic mutations. Myeloid differentiation primary response 88 (MYD88) mutations are frequently reported in chronic lymphocytic leukemia (CLL) and confer a worse prognosis. The objective of the present study was to assess the value of HRM analysis for the rapid screening of MYD88 mutations in patients with CLL. Genomic DNA samples were extracted from the bone marrow of 129 newly diagnosed patients with CLL. A plasmid with an MYD88‑L265P mutation was constructed, and the p.L265P substitution, which is the predominant MYD88 mutation in CLL, was detected using HRM analysis and direct sequencing. The plasmid pCMV‑MYD88‑L265P‑Mu was successfully constructed as a positive control, and was verified by direct sequencing. The normalized and shifted melting curves of 6/129 (4.65%) samples were clearly different from those of other patients by HRM analysis. In addition, the 794T>C mutation in MYD88 was identified in 6 (4.65%) patients by direct sequencing. Sensitivity evaluation revealed that the HRM assay had a higher sensitivity (to 1% dilution) than direct sequencing, in addition to being convenient and time‑saving. The MYD88 p.L256P mutation has been implicated to be associated with adverse prognosis in CLL. HRM analysis has the potential to be a routine prescreening technique to identify the MYD88 p.L256P mutation and may facilitate the clinical treatment of CLL.
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1 

Hamblin TJ, Davis Z, Gardiner A, Oscier DG and Stevenson FK: Unmutated IgV(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 94:1848–1854. 1999.PubMed/NCBI

2 

Baliakas P, Hadzidimitriou A, Sutton LA, Rossi D, Minga E, Villamor N, Larrayoz M, Kminkova J, Agathangelidis A, Davis Z, et al: Recurrent mutations refine prognosis in chronic lymphocytic leukemia. Leukemia. 29:329–336. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Puente XS, Pinyol M, Quesada V, Conde L, Ordóñez GR, Villamor N, Escaramis G, Jares P, Beà S, González-Díaz M, et al: Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukemia. Nature. 475:101–105. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Wang L, Lawrence MS, Wan Y, Stojanov P, Sougnez C, Stevenson K, Werner L, Sivachenko A, DeLuca DS, Zhang L, et al: SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 365:2497–2506. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, et al: MYD88 L265P somatic mutation in Waldenström's macroglobulinemia. N Engl J Med. 367:826–833. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Wang CZ, Lin J, Qian J, Shao R, Xue D, Qian W, Xiao GF, Deng ZQ, Yang J, Li Y and Chen XX: Development of high-resolution melting analysis for the detection of the MYD88 L265P mutation. Clin Biochem. 46:385–387. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Xu L, Hunter ZR, Yang G, Zhou Y, Cao Y, Liu X, Morra E, Trojani A, Greco A, Arcaini L, et al: MYD88 L265P in Waldenström's macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction. Blood. 121:2051–2058. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Martínez-Trillos A, Pinyol M, Navarro A, Aymerich M, Jares P, Juan M, Rozman M, Colomer D, Delgado J, Giné E, et al: Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome. Blood. 123:3790–3796. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Baliakas P, Hadzidimitriou A, Agathangelidis A, Rossi D, Sutton LA, Kminkova J, Scarfo L, Pospisilova S, Gaidano G, Stamatopoulos K, et al: Prognostic relevance of MYD88 mutations in CLL: The jury is still out. Blood. 126:1043–1044. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Improgo MR, Tesar B, Klitgaard JL, Magori-Cohen R, Yu L, Kasar S, Chaudhary D, Miao W, Fernandes SM, Hoang K, et al: MYD88 L265P mutations identify a prognostic gene expression signature and a pathway for targeted inhibition in CLL. Br J Haematol. 184:925–936. 2019.PubMed/NCBI

11 

Kim JA, Hwang B, Park SN, Huh S, Im K, Choi S, Chung HY, Huh J, Seo EJ, Lee JH, et al: Genomic profile of chronic lymphocytic leukemia in korea identified by targeted sequencing. PLoS One. 11:e01676412016. View Article : Google Scholar : PubMed/NCBI

12 

Cortese D, Sutton LA, Cahill N, Smedby KE, Geisler C, Gunnarsson R, Juliusson G, Mansouri L and Rosenquist R: On the way towards a ‘CLL prognostic index’: Focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort. Leukemia. 28:710–713. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Lin SC, Lo YC and Wu H: Helical assembly in the MYD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature. 465:885–890. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, et al: Oncogenically active MYD88 mutations in human lymphoma. Nature. 470:115–119. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Marino M, Monzani ML, Brigante G, Cioni K, Madeo B, Santi D, Maiorana A, Bettelli S, Moriondo V, Pignatti E, et al: High-resolution melting is a sensitive, cost-effective, time-saving technique for BRAF V600E Detection in thyroid FNAB washing liquid: A prospective cohort study. Eur Thyroid J. 4:73–81. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Chua KH, Lim SC, Ng CC, Lee PC, Lim YA, Lau TP and Chai HC: Development of high resolution melting analysis for the diagnosis of human malaria. Sci Rep. 5:156712015. View Article : Google Scholar : PubMed/NCBI

17 

Li J, Zhao GH, Lin R, Blair D, Sugiyama H and Zhu XQ: Rapid detection and identification of four major schistosoma species by high-resolution melt (HRM) analysis. Parasitol Res. 114:4225–4232. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Campregher PV and Hamerschlak N: Novel prognostic gene mutations identified in chronic lymphocytic leukemia and their impact on clinical practice. Clin Lymphoma Myeloma Leuk. 14:271–276. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Zenz T, Mertens D, Kuppers R, Döhner H and Stilgenbauer S: From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer. 10:37–50. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Soma LA, Craig FE and Swerdlow SH: The proliferation centre microenvironment and prognostic markers in chronic lymphocytic leukemia/small lymphocytic lymphoma. Hum Pathol. 37:152–159. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Oscier DG, Rose-Zerilli MJ, Winkelmann N, Gonzalez de Castro D, Gomez B, Forster J, Parker H, Parker A, Gardiner A, Collins A, et al: The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trail. Blood. 121:468–475. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Mansouri L, Cahill N, Gunnarsson R, Smedby KE, Tjönnfjord E, Hjalgrim H, Juliusson G, Geisler C and Rosenquist R: NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia. Leukemia. 27:521–514. 2013. View Article : Google Scholar

23 

Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, Forconi F, Marasca R, Laurenti L, Bruscaggin A, Cerri M, et al: Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood. 119:521–529. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Montillo M, Hamblin T, Hallek M, Montserrat E and Morra E: Chronic lymphocytic leukemia: Novel prognostic factors and their relevance for risk-adapted therapeutic strategies. Haematologica. 90:391–399. 2005.PubMed/NCBI

25 

Kawasaki T and Kawai T: Toll-like receptor signalling pathways. Front Immunol. 5:4612014. View Article : Google Scholar : PubMed/NCBI

26 

Gay NJ and Keith FJ: Drosophila toll and IL-1 receptor. Nature. 351:355–356. 1991. View Article : Google Scholar : PubMed/NCBI

27 

Schmidt U, Hulkkonen J and Naue J: Detection of a G>C single nucleotide polymorphism within a repetitive DNA sequence by high-resolution DNA melting. Int J Legal Med. 130:1181–1184. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Poon KS, Liu TC, Tan ML and Koay ES: One-step molecular detection of the MYD88 L265P mutation by unlabeled probe genotyping analysis. Mol Cell Probes. 29:74–77. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Rose-zerilli MJ, Gonzalez D, Gomez B, Parker H, Gardiner A, Parker A, Collins A, Catovsky D, Oscier DG and Strefford JC: The clinical significant of NOTCH1 and MYD88 mutations in patients enrolled onto the UK CLL4 treatment trial and in an early stage A cll cohort. Clin Lymph Myelom Leuk. 11 (Suppl 2):S2292011. View Article : Google Scholar

30 

Xu JJ, Yao FR, Jiang M, Zhang YT and Guo F: High-resolution melting analysis for rapid and sensitive NOTCH1 screening in chronic lymphocytic leukemia. Int J Mol Med. 39:415–422. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Sady H, Al-mekhlafi HM, Ngui R, Atroosh WM, Al-Delaimy AK, Nasr NA, Dawaki S, Abdulsalam AM, Ithoi I, Lim YA, et al: Detection of schistosomamansoni and schistosomahaematobium by real-time PCR with high resolution melting analysis. Int J Mol Sci. 16:16085–16103. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Hauss O and Müller O: The protein truncation test in mutation detection and molecular diagnosis. Methods Mol Biol. 375:151–164. 2007.PubMed/NCBI

33 

Hayashi K: PCR-SSCP: A method for detection of mutations. Genet Anal Tech Appl. 9:73–79. 1992. View Article : Google Scholar : PubMed/NCBI

34 

de Juan Jiménez I, Cardeñosa EE, Suela SP, González EB, Trejo DS, Lluch OF and Gilabert PB: Advantage of high-resolution melting curve analysis over conformation-sensitive gel electrophoresis for mutational screening of BRCA1 and BRCA2 genes. Clin Chim Acta. 412:578–582. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Chang YS, Lin CY, Yang SF, Ho CM and Chang JG: High-resolution melting analysis for gene scanning of adenomatous polyposis coli (APC) gene with oral squamous cell carcinoma samples. Appl Immunohistochem Mol Morphol. 24:97–104. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Hondow HL, Fox SB, Mitchell G, Scott RJ, Beshay V, Wong SQ, kConFab Investigators and Dobrovic A: A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes. BMC Cancer. 11:2652011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang M, Li J, Zhou J, Xing C, Xu JJ and Guo F: High‑resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia Corrigendum in /10.3892/ol.2019.10582. Oncol Lett 18: 814-821, 2019.
APA
Jiang, M., Li, J., Zhou, J., Xing, C., Xu, J., & Guo, F. (2019). High‑resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia Corrigendum in /10.3892/ol.2019.10582. Oncology Letters, 18, 814-821. https://doi.org/10.3892/ol.2019.10342
MLA
Jiang, M., Li, J., Zhou, J., Xing, C., Xu, J., Guo, F."High‑resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia Corrigendum in /10.3892/ol.2019.10582". Oncology Letters 18.1 (2019): 814-821.
Chicago
Jiang, M., Li, J., Zhou, J., Xing, C., Xu, J., Guo, F."High‑resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia Corrigendum in /10.3892/ol.2019.10582". Oncology Letters 18, no. 1 (2019): 814-821. https://doi.org/10.3892/ol.2019.10342
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang M, Li J, Zhou J, Xing C, Xu JJ and Guo F: High‑resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia Corrigendum in /10.3892/ol.2019.10582. Oncol Lett 18: 814-821, 2019.
APA
Jiang, M., Li, J., Zhou, J., Xing, C., Xu, J., & Guo, F. (2019). High‑resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia Corrigendum in /10.3892/ol.2019.10582. Oncology Letters, 18, 814-821. https://doi.org/10.3892/ol.2019.10342
MLA
Jiang, M., Li, J., Zhou, J., Xing, C., Xu, J., Guo, F."High‑resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia Corrigendum in /10.3892/ol.2019.10582". Oncology Letters 18.1 (2019): 814-821.
Chicago
Jiang, M., Li, J., Zhou, J., Xing, C., Xu, J., Guo, F."High‑resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia Corrigendum in /10.3892/ol.2019.10582". Oncology Letters 18, no. 1 (2019): 814-821. https://doi.org/10.3892/ol.2019.10342
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