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Article

Prognostic significance of inflammatory cell response in patients with colorectal cancer

  • Authors:
    • Katarzyna Jakubowska
    • Mariusz Koda
    • Wojciech Kisielewski
    • Luiza Kańczuga‑Koda
    • Waldemar Famulski
  • View Affiliations / Copyright

    Affiliations: Department of Pathomorphology, Comprehensive Cancer Center, 15‑027 Białystok, Poland, Department of General Pathomorphology, Medical University of Białystok, 15‑269 Białystok, Poland, Department of Medical Pathomorphology, Medical University of Białystok, 15‑269 Białystok, Poland
  • Pages: 783-791
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    Published online on: May 13, 2019
       https://doi.org/10.3892/ol.2019.10343
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Abstract

Cancer cells are characterized by a low antigenic immunogenicity, a rapid growth and an immunosuppressive effect on the extracellular matrix. These properties induce a weak immune response in colorectal cancer (CRC) carcinogenesis. It is therefore crucial to determine the composition of the inflammatory mass, including neutrophils, macrophages and eosinophils in the tumor tissue of patients with CRC, and to analyze other clinicopathological parameters. The present study included 144 patients diagnosed with CRC. Tissue samples obtained from routine histopathological diagnosis were stained with hematoxylin and eosin. Inflammatory cells were assessed in the invasive front and in the center of the tumor by light microscopy under a high‑power magnification. The percentage of neutrophils in the invasive front was significantly higher compared with that in the center of the tumor mass (P<0.01). Macrophages and eosinophils were present in the invasive front and in the center of tumor mass in most cases. The presence of neutrophils, macrophages and eosinophils was correlated with various clinicopathological features. Patients with macrophages present in the center of tumor mass had longer disease‑free survival time (P=0.041). In conclusion, the present study demonstrated that the inflammatory cell infiltrate served a significant role in the immune response of patients with CRC. It should be noted that the presence of macrophages localized in the stroma of the central part of the primary tumor mass was associated with the survival time of patients with CRC.
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1 

Testa U, Pelosi E and Castelli G: Colorectal cancer: Genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells. Med Sci (Basel). 6:E312018.PubMed/NCBI

2 

Merlano MC, Granetto C, Fea E, Ricci V and Garrone O: Heterogeneity of colon cancer: From bench to bedside. ESMO Open. 2:e0002182017. View Article : Google Scholar : PubMed/NCBI

3 

Eljaszewicz A, Gackowska L, Kubiszewska I, Jankowski M, Urbańska M, Wiese M, Helmin-Basa A, Michałkiewicz J and Zegarski W: Aktywność makrofagów w rozwoju choroby nowotworowej. Współczesna Onkologia. 1:1–6. 2010.(In Poland). View Article : Google Scholar

4 

Hong-Fang T, Yan-Hui P, Lei B and Wan-Xing Z: Effects of granulocyte colony-stimulating factor on opsonin receptor expression and neutrophil antibacterial activity in a mouse model of severe acute pancreatitis. Postepy Hig Med Dosw (Online). 71:352–358. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Dubois RN: Role of inflammation and inflammatory mediators in colorectal cancer. Trans Am Clin Climatol Assoc. 125:358–372; discussion 372–373. 2014.PubMed/NCBI

6 

Dunn GP, Old LJ and Schreiber RD: The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 21:137–148. 2004. View Article : Google Scholar : PubMed/NCBI

7 

McCourt M, Wang JH, Sookhai S and Redmond HP: Activated human neutrophils release hepatocyte growth factor/scatter factor. Eur J Surg Oncol. 27:396–403. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Shamamian P, Schwartz JD, Pocock BJ, Monea S, Whiting D, Marcus SG and Mignatti P: Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: A role for inflammatory cells in tumor invasion and angiogenesis. J Cell Physiol. 189:197–206. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Prizment AE, Vierkant RA, Smyrk TC, Tillmans LS, Lee JJ, Sriramarao P, Nelson HH, Lynch CF, Thibodeau SN, Church TR, et al: Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa women's health study. Mod Pathol. 29:516–527. 2016. View Article : Google Scholar : PubMed/NCBI

10 

NCCN Clinical Practice Guidelines in Oncology, . Colon Cancer. https://www.nccn.org.asp

11 

Kyriakos M: The President cancer, the Dukes classification, and confusion. Arch Pathol Lab Med. 109:1063–1066. 1985.PubMed/NCBI

12 

Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC and Gwyther SG: New guidelines to evaluate the response to treatment in solid tumors. European organization for research and treatment of cancer, national cancer institute of the United States, national cancer institute of Canada. J Natl Cancer Inst. 92:205–216. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Lin Q, Wei Y, Ren L, Zhong Y, Qin C, Zheng P, Xu P, Zhu D, Ji M and Xu J: Tumor deposit is a poor prognostic indicator in patients who underwent simultaneous resection for synchronous colorectal liver metastases. Onco Targets Ther. 8:233–240. 2015.PubMed/NCBI

14 

Huijbers A, Tollenaar RA, v Pelt GW, Zeestraten EC, Dutton S, McConkey CC, Domingo E, Smit VT, Midgley R, Warren BF, et al: The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: Validation in the VICTOR trial. Ann Oncol. 24:179–185. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Morodomi T, Isomoto H, Shirouzu K, Kakegawa K, Irie K and Morimatsu M: An index for estimating the probability of lymph node metastasis in rectal cancers. Lymph node metastasis and the histopathology of actively invasive regions of cancer. Cancer. 63:539–543. 1989. View Article : Google Scholar : PubMed/NCBI

16 

Klintrup K, Mäkinen JM, Kauppila S, Väre PO, Melkko J, Tuominen H, Tuppurainen K, Mäkelä J, Karttunen TJ and Mäkinen MJ: Inflammation and prognosis in colorectal cancer. Eur J Cancer. 41:2645–2654. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Richards CH, Flegg KM, Roxburgh CS, Going JJ, Mohammed Z, Horgan PG and McMillan DC: The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer. Br J Cancer. 106:2010–2015. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Väyrynen JP, Sajanti SA, Klintrup K, Mäkelä J, Herzig KH, Karttunen TJ, Tuomisto A and Mäkinen MJ: Characteristics and significance of colorectal cancer associated lymphoid reaction. Int J Cancer. 134:2126–2135. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Ueno H, Jones AM, Wilkinson KH, Jass JR and Talbot IC: Histological categorization of fibrotic cancer stroma in advanced rectal cancer. Gut. 53:581–586. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Lichtman MA, Kipps TJ, Seligsohn U, Kaushansky K and Prchal JT: Williams Hematology. (8th). McGraw-Hill Companies. 875–999. 2010.

21 

Nowak B: Patomechanizm rozwoju reakcji zapalnej. Przegl Reumatol. R.1 nr 4; s.5. 2005.

22 

Rao HL, Chen JW, Li M, Xiao YB, Fu J, Zeng YX, Cai MY and Xie D: Increased intratumoral neutrophil in colorectal carcinomas correlates closely with malignant phenotype and predicts patients' adverse prognosis. PLoS One. 7:e308062012. View Article : Google Scholar : PubMed/NCBI

23 

Arelaki S, Arampatzioglou A, Kambas K, Papagoras C, Miltiades P, Angelidou I, Mitsios A, Kotsianidis I, Skendros P, Sivridis E, et al: Gradient infiltration of neutrophil extracellular traps in colon cancer and evidence for their involvement in tumour growth. PLoS One. 11:e01544842016. View Article : Google Scholar : PubMed/NCBI

24 

Galdiero MR, Bianchi P, Grizzi F, Di Caro G, Basso G, Ponzetta A, Bonavita E, Barbagallo M, Tartari S, Polentarutti N, et al: Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer. Int J Cancer. 139:446–456. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Mizuno R, Kawada K, Itatani Y, Ogawa R, Kiyasu Y and Sakai Y: The role of tumor-associated neutrophils in colorectal cancer. Int J Mol Sci. 20:E5292019. View Article : Google Scholar : PubMed/NCBI

26 

Mlecnik B, Tosolini M, Kirilovsky A, Berger A, Bindea G, Meatchi T, Bruneval P, Trajanoski Z, Fridman WH, Pagès F and Galon J: Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol. 29:610–618. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Kiziltaş S, Sezgin Ramadan S, Topuzoğlu A and Küllü S: Does the severity of tissue eosinophilia of colonic neoplasms reflect their malignancy potential? Turk J Gastroenterol. 19:239–244. 2008.PubMed/NCBI

28 

Cho H, Lim SJ, Won KY, Bae GE, Kim GY, Min JW and Noh BJ: Eosinophils in colorectal neoplasms associated with expression of CCL11 and CCL24. J Pathol Transl Med. 50:45–51. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Moezzi J, Gopalswamy N, Haas RJ Jr, Markert RJ, Suryaprasad S and Bhutani MS: Stromal eosinophilia in colonic epithelial neoplasms. Am J Gastroenterol. 95:520–523. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Harbaum L, Pollheimer MJ, Kornprat P, Lindtner RA, Bokemeyer C and Langner C: Peritumoral eosinophils predict recurrence in colorectal cancer. Mod Pathol. 28:403–413. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Mantovani A, Bottazzi B, Colotta F, Sozzani S and Ruco L: The origin and function of tumor-associated macrophages. Immunol Today. 13:265–270. 1992. View Article : Google Scholar : PubMed/NCBI

32 

Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J and Harris AL: Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. 56:4625–4629. 1996.PubMed/NCBI

33 

Mantovani A: Tumor-associated macrophages in neoplastic progression: A paradigm for the in vivo function of chemokines. Lab Invest. 71:5–16. 1994.PubMed/NCBI

34 

Afik R, Zigmond E, Vugman M, Klepfish M, Shimshoni E, Pasmanik-Chor M, Shenoy A, Bassat E, Halpern Z, Geiger T, et al: Tumor macrophages are pivotal constructors of tumor collagenous matrix. J Exp Med. 213:2315–2331. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Ohtani H, Naito Y, Saito K and Nagura H: Expression of costimulatory molecules B7-1 and B7-2 by macrophages along invasive margin of colon cancer: A possible antitumor immunity? Lab Invest. 77:231–241. 1997.PubMed/NCBI

36 

Khorana AA, Ryan CK, Cox C, Eberly S and Sahasrabudhe DM: Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma: A role for the host response in prognosis. Cancer. 97:960–968. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Hamilton SR, Bosman FT, Boffetta P, et al: Carcinoma of the colon and rectum In: WHO classification of tumours of the digestive system. Bosman FT, Carneiro F, Hruban RH and Theise ND: (4th). IARC. (Lyon). 134–146. 2010.

38 

Popovic ZV, Sandhoff R, Sijmonsma TP, Kaden S, Jennemann R, Kiss E, Tone E, Autschbach F, Platt N, Malle E and Gröne HJ: Sulfated glycosphingolipid as mediator of phagocytosis: SM4s enhances apoptotic cell clearance and modulates macrophage activity. J Immunol. 179:6770–6782. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Funada Y, Noguchi T, Kikuchi R, Takeno S, Uchida Y and Gabbert HE: Prognostic significance of CD8+ T cell and macrophage peritumoral infiltration in colorectal cancer. Oncol Rep. 10:309–313. 2003.PubMed/NCBI

40 

Zhou Q, Peng RQ, Wu XJ, Xia Q, Hou JH, Ding Y, Zhou QM, Zhang X, Pang ZZ, Wan DS, et al: The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer. J Transl Med. 8:132010. View Article : Google Scholar : PubMed/NCBI

41 

Koelzer VH, Canonica K, Dawson H, Sokol L, Karamitopoulou-Diamantis E, Lugli A and Zlobec I: Phenotyping of tumor-associated macrophages in colorectal cancer: Impact on single cell invasion (tumor budding) and clinicopathological outcome. Oncoimmunology. 5:e11066772015. View Article : Google Scholar : PubMed/NCBI

42 

Ammendola M, Patruno R, Sacco R, Marech I, Sammarco G, Zuccalà V, Luposella M, Zizzo N, Gadaleta C, Porcelli M, et al: Mast cells positive to tryptase and tumour-associated macrophages correlate with angiogenesis in locally advanced colorectal cancer patients undergone to surgery. Expert Opin Ther Targets. 20:533–540. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Gulubova M, Ananiev J, Yovchev Y, Julianov A, Karashmalakov A and Vlaykova T: The density of macrophages in colorectal cancer is inversely correlated to TGF-β1 expression and patients' survival. J Mol Histol. 44:679–692. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Kinouchi M, Miura K, Mizoi T, Ishida K, Fujibuchi W, Sasaki H, Ohnuma S, Saito K, Katayose Y, Naitoh T, et al: Infiltration of CD40-positive tumor-associated macrophages indicates a favorable prognosis in colorectal cancer patients. Hepatogastroenterology. 60:83–88. 2013.PubMed/NCBI

45 

Fernández-Aceñero MJ, Galindo-Gallego M, Sanz J and Aljama A: Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma. Cancer. 88:1544–1548. 2000. View Article : Google Scholar : PubMed/NCBI

46 

Wikberg ML, Ling A, Li X, Öberg Å, Edin S and Palmqvist R: Neutrophil infiltration is a favorable prognostic factor in early stages of colon cancer. Hum Pathol. 68:193–202. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jakubowska K, Koda M, Kisielewski W, Kańczuga‑Koda L and Famulski W: Prognostic significance of inflammatory cell response in patients with colorectal cancer. Oncol Lett 18: 783-791, 2019.
APA
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., & Famulski, W. (2019). Prognostic significance of inflammatory cell response in patients with colorectal cancer. Oncology Letters, 18, 783-791. https://doi.org/10.3892/ol.2019.10343
MLA
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Famulski, W."Prognostic significance of inflammatory cell response in patients with colorectal cancer". Oncology Letters 18.1 (2019): 783-791.
Chicago
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Famulski, W."Prognostic significance of inflammatory cell response in patients with colorectal cancer". Oncology Letters 18, no. 1 (2019): 783-791. https://doi.org/10.3892/ol.2019.10343
Copy and paste a formatted citation
x
Spandidos Publications style
Jakubowska K, Koda M, Kisielewski W, Kańczuga‑Koda L and Famulski W: Prognostic significance of inflammatory cell response in patients with colorectal cancer. Oncol Lett 18: 783-791, 2019.
APA
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., & Famulski, W. (2019). Prognostic significance of inflammatory cell response in patients with colorectal cancer. Oncology Letters, 18, 783-791. https://doi.org/10.3892/ol.2019.10343
MLA
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Famulski, W."Prognostic significance of inflammatory cell response in patients with colorectal cancer". Oncology Letters 18.1 (2019): 783-791.
Chicago
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Famulski, W."Prognostic significance of inflammatory cell response in patients with colorectal cancer". Oncology Letters 18, no. 1 (2019): 783-791. https://doi.org/10.3892/ol.2019.10343
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