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MicroRNA‑410‑3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells

  • Authors:
    • Liang Zhang
    • Yuwen Pang
    • Xiaobin Cui
    • Wei Jia
    • Wenwen Cui
    • Yang Liu
    • Chunxia Liu
    • Feng Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Medicine, Shihezi University, Shihezi, Xinjiang 832002, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 936-943
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    Published online on: May 13, 2019
       https://doi.org/10.3892/ol.2019.10345
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Abstract

Rhabdomyosarcoma (RMS) is one of the most common types of soft tissue sarcoma in children; however, the pathogenesis of RMS is unclear. MicroRNAs (miRs) are involved in the development and progression of RMS. The role of miR‑410‑3p in RMS cell invasion, migration, proliferation and apoptosis, and its possible mechanism were investigated in the current study. Reverse transcription‑quantitative polymerase chain reaction and western blot analysis were performed to detect the expression of miR‑410‑3p in RMS tissues and cells. In addition, the present study investigated the expression levels of molecules associated with the epithelial‑mesenchymal transition (EMT), including E‑cadherin, N‑cadherin, Slug and Snail, and apoptotic factors, including Bcl‑2‑associated X protein (bax), cleaved‑caspase 3, cleaved poly (ADP‑ribose) polymerase (PARP), p53 and Bcl‑2. Cell Counting Kit‑8, terminal deoxynucleotidyl transferase dUTP nick end labeling and Transwell assays were conducted to determine the functional roles of miR‑410‑3p. Exogenous expression of miR‑410‑3p inhibited RMS cell invasion, migration and proliferation, induced apoptosis, suppressed the expression of Snail, Slug, N‑cadherin and Bcl‑2, and increased the expression of E‑cadherin, bax, cleaved‑caspase 3, cleaved PARP and p53. In summary, it was proposed that miR‑410‑3p overexpression suppressed invasion, migration and proliferation, downregulated the expression of EMT‑associated molecules, and promoted apoptosis and the expression of apoptotic factors in RMS cells. Therefore, miR‑410‑3p may serve as a novel tumor suppressor gene in RMS, and could possess diagnostic and therapeutic potentials for the treatment of RMS.
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1 

Jo VY and Doyle LA: Refinements in sarcoma classification in the current 2013 World Health Organization classification of tumours of soft tissue and bone. Surg Oncol Clin N Am. 25:621–643. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Toro JR, Travis LB, Wu HJ, Zhu K, Fletcher CD and Devesa SS: Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978–2001: An analysis of 26,758 cases. Int J Cancer. 119:2922–2930. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Pastore G, Peris-Bonet R, Carli M, Martínez-García C, Sánchez de Toledo J and Steliarova-Foucher E: Childhood soft tissue sarcomas incidence and survival in European children (1978–1997): Report from the automated childhood cancer information system project. Eur J Cancer. 42:2136–2149. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Weihkopf T, Blettner M, Dantonello T, Jung I, Klingebiel T, Koscielniak E, Lückel M, Spix C and Kaatsch P: Incidence and time trends of soft tissue sarcomas in German children 1985–2004-A report from the population-based German Childhood Cancer Registry. Eur J Cancer. 44:432–440. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Punyko JA, Mertens AC, Baker KS, Ness KK, Robison LL and Gurney JG: Long-term survival probabilities for childhood rhabdomyosarcoma. A population-based. Cancer. 103:1475–1483. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Sultan I, Qaddoumi I, Yaser S, Rodriguez-Galindo C and Ferrari A: Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: An analysis of 2,600 patients. J Clin Oncol. 27:3391–3397. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Kelly KM, Womer RB, Sorensen PH, Xiong QB and Barr FG: Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma. J Clin Oncol. 15:1831–1836. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Hron AJ and Asakura A: An examination of the role of transcriptional and posttranscriptional regulation in rhabdomyosarcoma. Stem Cells Int. 2017:24803752017. View Article : Google Scholar : PubMed/NCBI

9 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Rota R, Ciarapica R, Giordano A, Miele L and Locatelli F: MicroRNAs in rhabdomyosarcoma: Pathogenetic implications and translational potentiality. Mol Cancer. 10:1202011. View Article : Google Scholar : PubMed/NCBI

12 

Chen X, Xiao W, Chen W, Luo L, Ye S and Liu Y: The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition of lens epithelial cells. Cell Death Dis. 4:e8842013. View Article : Google Scholar : PubMed/NCBI

13 

Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, Egan DA, Li A, Huang G, Klein-Szanto AJ, et al: The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol. 10:202–210. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Sarver AL, Li L and Subramanian S: MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration. Cancer Res. 70:9570–9580. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Oh JS, Kim JJ, Byun JY and Kim IA: Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras. Int J Radiat Oncol Biol Phys. 76:5–8. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR and Zhao Q: MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer. Carcinogenesis. 34:713–722. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Eades G, Yao Y, Yang M, Zhang Y, Chumsri S and Zhou Q: miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J Biol Chem. 286:25992–26002. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Zhao D, Jia P, Wang W and Zhang G: VEGF-mediated suppression of cell proliferation and invasion by miR-410 in osteosarcoma. Mol Cell Biochem. 400:87–95. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Guo R, Gu J, Zhang Z, Wang Y and Gu C: MicroRNA-410 functions as a tumor suppressor by targeting angiotensin II type 1 receptor in pancreatic cancer. IUBMB Life. 67:42–53. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Zhang YF, Yu Y, Song WZ, Zhang RM, Jin S, Bai JW, Kang HB, Wang X and Cao XC: miR-410-3p suppresses breast cancer progression by targeting Snail. Oncol Rep. 36:480–486. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Liu C, Zhang A, Cheng L and Gao Y: miR410 regulates apoptosis by targeting Bak1 in human colorectal cancer cells. Mol Med Rep. 14:467–473. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Ye X, Jiang F, Li Y, Mu J, Si L, Wang X, Ning S and Li Z: Retracted: Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c. Cancer Sci. 105:875–882. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Li D, Yang Y, Zhu G, Liu X, Zhao M, Li X and Yang Q: MicroRNA-410 promotes cell proliferation by targeting BRD7 in non-small cell lung cancer. FEBS Lett. 589:2218–2223. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Shen S, Huang K, Wu Y, Ma Y, Wang J, Qin F and Ma J: A miR-135b-TAZ positive feedback loop promotes epithelial-mesenchymal transition (EMT) and tumorigenesis in osteosarcoma. Cancer Lett. 407:32–44. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Chen J, Yan D, Wu W, Zhu J, Ye W and Shu Q: MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN. Oncol Rep. 35:3285–3292. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhang X, Zheng L, Sun Y, Wang T and Wang B: Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. Oncol Rep. 34:302–310. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Zhu Y, Qiu P and Ji Y: TCGA-assembler: Open-source software for retrieving and processing TCGA data. Nat Methods. 11:599–600. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

31 

Grever MR, Schepartz SA and Chabner BA: The National Cancer Institute: Cancer drug discovery and development program. Semin Oncol 622–638. 1992.

32 

Hayes MN, McCarthy K, Jin A, Oliveira ML, Iyer S, Garcia SP, Sindiri S, Gryder B, Motala Z, Nielsen GP, et al: Vangl2/RhoA signaling pathway regulates stem cell self-renewal programs and growth in rhabdomyosarcoma. Cell Stem Cell. 22:414–427. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Love MI, Huber W and Anders S: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15:5502014. View Article : Google Scholar : PubMed/NCBI

34 

Breneman JC, Lyden E, Pappo AS, Link MP, Anderson JR, Parham DM, Qualman SJ, Wharam MD, Donaldson SS, Maurer HM, et al: Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma-a report from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol. 21:78–84. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Zhang B, Pan X, Cobb GP and Anderson TA: microRNAs as oncogenes and tumor suppressors. Dev Biol. 302:1–12. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Palumbo T, Poultsides GA, Kouraklis G, Liakakos T, Drakaki A, Peros G, Hatziapostolou M and Iliopoulos D: A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma. BMC Cancer. 16:3532016. View Article : Google Scholar : PubMed/NCBI

37 

Chen L, Zhang J, Feng Y, Li R, Sun X, Du W, Piao X, Wang H, Yang D, Sun Y, et al: MiR-410 regulates MET to influence the proliferation and invasion of glioma. Int J Biochem Cell Biol. 44:1711–1717. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Yang J and Weinberg RA: Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell. 14:818–829. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Yilmaz M and Christofori G: EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 28:15–33. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Gavert N and Ben-Ze'ev A: Epithelial-mesenchymal transition and the invasive potential of tumors. Trends Mol Med. 14:199–209. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Somarelli JA, Shetler S, Jolly MK, Wang X, Bartholf Dewitt S, Hish AJ, Gilja S, Eward WC, Ware KE, Levine H, et al: Mesenchymal-Epithelial transition in sarcomas is controlled by the combinatorial expression of MicroRNA 200s and GRHL2. Mol Cell Biol. 36:2503–2513. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Alba-Castellón L, Batlle R, Francí C, Fernández-Aceñero MJ, Mazzolini R, Peña R, Loubat J, Alameda F, Rodríguez R, Curto J, et al: Snail1 expression is required for sarcomagenesis. Neoplasia. 16:413–421. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Shen A, Zhang Y, Yang H, Xu R and Huang G: Overexpression of ZEB1 relates to metastasis and invasion in osteosarcoma. J Surg Oncol. 105:830–834. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Baum B, Settleman J and Quinlan MP: Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol. 19:294–308. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Yoshida T, Ozawa Y, Kimura T, Sato Y, Kuznetsov G, Xu S, Uesugi M, Agoulnik S, Taylor N, Funahashi Y and Matsui J: Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states. Br J Cancer. 110:1497–1505. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Tombolan L, Zampini M, Casara S, Boldrin E, Zin A, Bisogno G, Rosolen A, De Pittà C and Lanfranchi G: MicroRNA-27a contributes to rhabdomyosarcoma cell proliferation by suppressing RARA and RXRA. PLoS One. 10:e01251712015. View Article : Google Scholar : PubMed/NCBI

47 

Coda DM, Lingua MF, Morena D, Foglizzo V, Bersani F, Ala U, Ponzetto C and Taulli R: SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma. Cell Cycle. 14:1389–1402. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Sarver AL, Li L and Subramanian S: MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration. Cancer Res. 70:9570–9580. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Pang Y, Cui X, Jia W, Cui W, Liu Y, Liu C and Li F: MicroRNA‑410‑3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells. Oncol Lett 18: 936-943, 2019.
APA
Zhang, L., Pang, Y., Cui, X., Jia, W., Cui, W., Liu, Y. ... Li, F. (2019). MicroRNA‑410‑3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells. Oncology Letters, 18, 936-943. https://doi.org/10.3892/ol.2019.10345
MLA
Zhang, L., Pang, Y., Cui, X., Jia, W., Cui, W., Liu, Y., Liu, C., Li, F."MicroRNA‑410‑3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells". Oncology Letters 18.1 (2019): 936-943.
Chicago
Zhang, L., Pang, Y., Cui, X., Jia, W., Cui, W., Liu, Y., Liu, C., Li, F."MicroRNA‑410‑3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells". Oncology Letters 18, no. 1 (2019): 936-943. https://doi.org/10.3892/ol.2019.10345
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Pang Y, Cui X, Jia W, Cui W, Liu Y, Liu C and Li F: MicroRNA‑410‑3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells. Oncol Lett 18: 936-943, 2019.
APA
Zhang, L., Pang, Y., Cui, X., Jia, W., Cui, W., Liu, Y. ... Li, F. (2019). MicroRNA‑410‑3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells. Oncology Letters, 18, 936-943. https://doi.org/10.3892/ol.2019.10345
MLA
Zhang, L., Pang, Y., Cui, X., Jia, W., Cui, W., Liu, Y., Liu, C., Li, F."MicroRNA‑410‑3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells". Oncology Letters 18.1 (2019): 936-943.
Chicago
Zhang, L., Pang, Y., Cui, X., Jia, W., Cui, W., Liu, Y., Liu, C., Li, F."MicroRNA‑410‑3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells". Oncology Letters 18, no. 1 (2019): 936-943. https://doi.org/10.3892/ol.2019.10345
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