Computed tomography and magnetic resonance imaging features of solid serous cystadenomas of the pancreas

Chen,Jie‑Yu; Chen,Hai‑Yan; Pan,Yao; Shi,Dan; Yu,Ri‑Sheng

doi:10.3892/ol.2019.10346

Computed tomography and magnetic resonance imaging features of solid serous cystadenomas of the pancreas

Authors:
- Jie‑Yu Chen
- Hai‑Yan Chen
- Yao Pan
- Dan Shi
- Ri‑Sheng Yu
View Affiliations

Affiliations: Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
Published online on: May 13, 2019 https://doi.org/10.3892/ol.2019.10346
Pages: 898-906
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Solid serous cystadenomas (SSC) of the pancreas are the rarest benign type of serous cystic neoplasms and are frequently misdiagnosed, resulting in unnecessary invasive surgical procedures. A retrospective study was performed to collect imaging features of SSC using computed tomography (CT) and magnetic resonance imaging. The clinical data and imaging study of 5 female patients with pathologically confirmed SSC (mean age, 44.2 years; range, 23‑69 years) diagnosed between January 2006 and July 2017 were retrospectively analyzed. The imaging study was assessed by two experienced radiologists in consensus. All patients had tumors with a mean size of 2.3 cm (range, 1.5‑3.2 cm; 4/5 lesions ≤3 cm). The tumors were located in the tail of pancreas in 3 cases and in the neck of the pancreas in 2 cases. The tumors were all well defined, with an ovoid and lobulated shape and fibrous capsules. Consequently, they presented as low density on unenhanced CT images, marked hyperintensity on T2‑weighted images in 4 cases and slight hyperintensity in 1 case. However, they exhibited heterogeneous wash‑in and wash‑out enhancement in 2 cases and moderate and prolonged enhancement in 3 cases. The apparent diffusion coefficient (ADC) values of the lesions were >2x10‑3 mm2/sec. Therefore, a small tumor size, signal intensity on T2‑weighted images, high ADC values, fibrous capsules and enhancement patterns may be indicative imaging features of SSCs.

View Figures

View References

1	Chandwani R and Allen PJ: Cystic neoplasms of the pancreas. Annu Rev Med. 67:45–57. 2016. View Article : Google Scholar : PubMed/NCBI
2	Kosmahl M, Wagner J, Peters K, Sipos B and Klöppel GN: Serous cystic neoplasms of the pancreas: An immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Surg Pathol. 28:339–346. 2004. View Article : Google Scholar : PubMed/NCBI
3	Kishida Y, Matsubayashi H, Okamura Y, Uesaka K, Sasaki K, Sawai H, Imai K and Ono H: A case of solid-type serous cystadenoma mimicking neuroendocrine tumor of the pancreas. J Dig Dis. 15:211–215. 2014. View Article : Google Scholar : PubMed/NCBI
4	Sun HY, Kim SH, Kim MA, Lee JY, Han JK and Choi BI: CT imaging spectrum of pancreatic serous tumors: Based on new pathologic classification. Eur J Radiol. 75:e45–e55. 2010. View Article : Google Scholar : PubMed/NCBI
5	Kimura W, Moriya T, Hirai I, Hanada K, Abe H, Yanagisawa A, Fukushima N, Ohike N, Shimizu M, Hatori T, et al: Multicenter study of serous cystic neoplasm of the Japan pancreas society. Pancreas. 41:380–387. 2012. View Article : Google Scholar : PubMed/NCBI
6	Machado MC and Machado MA: Solid serous adenoma of the pancreas: An uncommon but important entity. Eur J Surg Oncol. 34:730–733. 2008. View Article : Google Scholar : PubMed/NCBI
7	Perez-Ordonez B, Naseem A, Lieberman PH and Klimstra DS: Solid serous adenoma of the pancreas. The solid variant of serous cystadenoma? Am J Surg Pathol. 20:1401–1405. 1996. View Article : Google Scholar : PubMed/NCBI
8	Yamaguchi M: Solid serous adenoma of the pancreas: A solid variant of serous cystadenoma or a separate disease entity? J Gastroenterol. 41:177–178. 2006. View Article : Google Scholar : PubMed/NCBI
9	European Study Group on Cystic Tumours of the Pancreas, . European evidence-based guidelines on pancreatic cystic neoplasms. Gut. 67:789–804. 2018. View Article : Google Scholar : PubMed/NCBI
10	Jais B, Rebours V, Malleo G, Salvia R, Fontana M, Maggino L, Bassi C, Manfredi R, Moran R, Lennon AM, et al: Serous cystic neoplasm of the pancreas: A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas). Gut. 65:305–312. 2016. View Article : Google Scholar : PubMed/NCBI
11	Yu MH, Lee JY, Kim MA, Kim SH, Lee JM, Han JK and Choi BI: MR imaging features of small solid pseudopapillary tumors: Retrospective differentiation from other small solid pancreatic tumors. AJR Am J Roentgenol. 195:1324–1332. 2010. View Article : Google Scholar : PubMed/NCBI
12	Stern JR, Frankel WL, Ellison EC and Bloomston M: Solid serous microcystic adenoma of the pancreas. World J Surg Oncol. 5:262007. View Article : Google Scholar : PubMed/NCBI
13	Reese SA, Traverso LW, Jacobs TW and Longnecker DS: Solid serous adenoma of the pancreas: A rare variant within the family of pancreatic serous cystic neoplasms. Pancreas. 33:96–99. 2006. View Article : Google Scholar : PubMed/NCBI
14	Sanaka MR, Kowalski TE, Brotz C, Yeo CJ, McCue P and Palazzo J: Solid serous adenoma of the pancreas: A rare form of serous cystadenoma. Dig Dis Sci. 52:3154–3156. 2007. View Article : Google Scholar : PubMed/NCBI
15	Yasuda A, Sawai H, Ochi N, Matsuo Y, Okada Y and Takeyama H: Solid variant of serous cystadenoma of the pancreas. Arch Med Sci. 7:353–355. 2011. View Article : Google Scholar : PubMed/NCBI
16	Gabata T, Terayama N, Yamashiro M, Takamatsu S, Yoshida K, Matsui O, Usukura M, Takeshita M and Minato H: Solid serous cystadenoma of the pancreas: MR imaging with pathologic correlation. Abdom Imaging. 30:605–609. 2005. View Article : Google Scholar : PubMed/NCBI
17	Lee SE, Kwon Y, Jang JY, Kim YH, Hwang DW, Kim MA, Kim SH and Kim SW: The morphological classification of a serous cystic tumor (SCT) of the pancreas and evaluation of the preoperative diagnostic accuracy of computed tomography. Ann Surg Oncol. 15:2089–2095. 2008. View Article : Google Scholar : PubMed/NCBI
18	Casadei R, D'Ambra M, Pezzilli R, Ricci C, Calculli L, Lega S, Antonacci N, Monari F and Minni F: Solid serous microcystic tumor of the pancreas. JOP. 9:538–540. 2008.PubMed/NCBI
19	Lee SD, Han SS and Hong EK: Solid serous cystic neoplasm of the pancreas with invasive growth. J Hepatobiliary Pancreat Sci. 20:454–456. 2013. View Article : Google Scholar : PubMed/NCBI
20	Wu W, Hong X, Li J, Dai M, Wang W, Tong A, Zhu Z, Dai H and Zhao Y: Solid serous cystadenoma of the pancreas: A case report of 2 patients revealing vimentin, β-catenin, α-1 antitrypsin, and α-1 antichymotrypsin as new immunohistochemistry staining markers. Medicine (Baltimore). 94:e6442015. View Article : Google Scholar : PubMed/NCBI
21	Katsourakis A, Dimitriou I, Noussios G, Chatzis I and Chatzitheoclitos E: Solid serous adenoma of the pancreas: A case report and review of the literature. Case Rep Surg. 2016:37302492016.PubMed/NCBI
22	Hamid M, Tbouda M, Majbar AM, Raiss M and Ahallat M: Pancreatic solid serous cystadenoma treated by laparoscopy: Presentation of a new case report and review of the literature. Int J Surg Case Rep. 40:97–101. 2017. View Article : Google Scholar : PubMed/NCBI
23	Yamamoto T, Takahashi N, Yamaguchi T and Imamura Y: A case of solid variant type of pancreatic serous cystadenoma mimicking islet cell tumor. Clin Imaging. 28:49–51. 2004. View Article : Google Scholar : PubMed/NCBI
24	Geramizadeh B, Dabbaghmanesh MH, Nikeghbalian S and Soleimani N: Solid serous adenoma of pancreas, misdiagnosed as neuroendocrine tumor, a rare case report and review of the literature. J Gastrointest Cancer. 47:462–465. 2016. View Article : Google Scholar : PubMed/NCBI
25	Matsumoto M, Iguchi M, Ohtsuki Y, Kimura M, Watanabe R, Watanabe N, Okada Y, Kurabayashi A, Takahashi T and Furihata M: A case of solid serous adenoma of the pancreas ultrastructurally harbouring ribosome-lamella complexes. Pathology. 38:361–364. 2006. View Article : Google Scholar : PubMed/NCBI
26	Hayashi K, Fujimitsu R, Ida M, Sakamoto K, Higashihara H, Hamada Y and Yoshimitsu K: CT differentiation of solid serous cystadenoma vs endocrine tumor of the pancreas. Eur J Radiol. 81:e203–e208. 2012. View Article : Google Scholar : PubMed/NCBI
27	Jang KM, Kim SH, Song KD, Kim YK, Lee SJ and Choi D: Differentiation of solid-type serous cystic neoplasm from neuroendocrine tumour in the pancreas: Value of abdominal MRI with diffusion-weighted imaging in comparison with MDCT. Clin Radiol. 70:153–160. 2015. View Article : Google Scholar : PubMed/NCBI
28	Hayano K, Miura F, Amano H, Toyota N, Wada K, Kato K, Sano K, Takeshita K, Aoyagi T, Shuto K, et al: Correlation of apparent diffusion coefficient measured by diffusion-weighted MRI and clinicopathologic features in pancreatic cancer patients. J Hepatobiliary Pancreat Sci. 20:243–248. 2013. View Article : Google Scholar : PubMed/NCBI
29	Bakir B, Salmaslioğlu A, Poyanlı A, Rozanes I and Acunas B: Diffusion weighted MR imaging of pancreatic islet cell tumors. Eur J Radiol. 74:214–220. 2010. View Article : Google Scholar : PubMed/NCBI
30	Yao X, Ji Y, Zeng M, Rao S and Yang B: Solid pseudopapillary tumor of the pancreas: Cross-sectional imaging and pathologic correlation. Pancreas. 39:486–491. 2010. View Article : Google Scholar : PubMed/NCBI
31	Baek JH, Lee JM, Kim SH, Kim SJ, Kim SH, Lee JY, Han JK and Choi BI: Small (<or=3 cm) solid pseudopapillary tumors of the pancreas at multiphasic multidetector CT. Radiology. 257:97–106. 2010. View Article : Google Scholar : PubMed/NCBI
32	Jang KM, Kim SH, Kim YK, Park MJ, Lee MH, Hwang J and Rhim H: Imaging features of small (≤3 cm) pancreatic solid tumors on gadoxetic-acid-enhanced MR imaging and diffusion-weighted imaging: An initial experience. Magn Reson Imaging. 30:916–925. 2012. View Article : Google Scholar : PubMed/NCBI
33	Javadi S, Menias CO, Korivi BR, Shaaban AM, Patnana M, Alhalabi K and Elsayes KM: Pancreatic calcifications and calcified pancreatic masses: Pattern recognition approach on CT. AJR Am J Roentgenol. 209:77–87. 2017. View Article : Google Scholar : PubMed/NCBI
34	Sahani DV, Kadavigere R, Blake M, Fernandez-Del Castillo C, Lauwers GY and Hahn PF: Intraductal papillary mucinous neoplasm of pancreas: Multi-detector row CT with 2D curved reformations-correlation with MRCP. Radiology. 238:560–569. 2006. View Article : Google Scholar : PubMed/NCBI