Open Access

Expression and clinical significance of miRNA-145 and miRNA-218 in laryngeal cancer

  • Authors:
    • Libing Guo
    • Xiuyu Cai
    • Weihan Hu
    • Wenfeng Hua
    • Wen Yan
    • Yucheng Lin
    • Shengsong Yin
    • Yue Chen
  • View Affiliations

  • Published online on: May 13, 2019     https://doi.org/10.3892/ol.2019.10353
  • Pages: 764-770
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Expression of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer and the relationship between them and the clinicopathological parameters and prognosis were investigated. The clinical medical records of 132 patients with laryngeal cancer, who were admitted to Guangdong Second Provincial General Hospital from February 2009 to March 2014, were retrospectively analyzed and comprised the study group. The data of physical examinations of 56 healthy volunteers who took physical examinations in the same hospital comprised the control group. RT-qPCR was used to detect the expression levels of miRNA-145 and miRNA-218 in serum of the patients in the two groups. According to the relative expression levels of miRNA-145 and miRNA-218 in serum of the patients in the study group on the day when they left hospital, the study group was divided into the high expression group (n=73 patients) and the low expression group (n=59 patients). The patients received a 48-month follow-up visit and their survival condition was recorded and the Kaplan-Meier was used to carry out the survival analysis. The expression levels of miRNA-145 and miRNA-218 in serum of the patients in the study group were lower than those in the control group (P<0.05). The median survival time of the patients in the high expression group was 30 months while the median survival time of the patients in the low expression group was 26 months. The expression levels of miRNA-145 and miRNA‑218 in serum of patients with laryngeal cancer decreased, the higher the expression levels of miRNA‑145 and miRNA-218 in serum of patients with laryngeal cancer were, the better the prognosis was. miRNA-145 and miRNA‑218 were used as indicators of assessing the prognosis of patients with laryngeal cancer.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Guo L, Cai X, Hu W, Hua W, Yan W, Lin Y, Yin S and Chen Y: Expression and clinical significance of miRNA-145 and miRNA-218 in laryngeal cancer. Oncol Lett 18: 764-770, 2019
APA
Guo, L., Cai, X., Hu, W., Hua, W., Yan, W., Lin, Y. ... Chen, Y. (2019). Expression and clinical significance of miRNA-145 and miRNA-218 in laryngeal cancer. Oncology Letters, 18, 764-770. https://doi.org/10.3892/ol.2019.10353
MLA
Guo, L., Cai, X., Hu, W., Hua, W., Yan, W., Lin, Y., Yin, S., Chen, Y."Expression and clinical significance of miRNA-145 and miRNA-218 in laryngeal cancer". Oncology Letters 18.1 (2019): 764-770.
Chicago
Guo, L., Cai, X., Hu, W., Hua, W., Yan, W., Lin, Y., Yin, S., Chen, Y."Expression and clinical significance of miRNA-145 and miRNA-218 in laryngeal cancer". Oncology Letters 18, no. 1 (2019): 764-770. https://doi.org/10.3892/ol.2019.10353