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Identification of a novel lncRNA GABPB1‑IT1 that is downregulated and predicts a poor prognosis in non‑small cell lung cancer

  • Authors:
    • Jianjiang Xie
    • Guijing Xie
    • Quhai Chen
    • Zixun Xu
    • Wenjie Bai
    • Mindong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510180, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 838-845
    |
    Published online on: May 14, 2019
       https://doi.org/10.3892/ol.2019.10357
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Abstract

Lung cancer is the leading cause of cancer‑associated mortality worldwide. Previous studies have demonstrated that long non‑coding RNAs  (lncRNAs) serve important roles in diverse biological processes. However, the molecular function and prognostic value of the majority of lncRNAs in non‑small cell lung cancer (NSCLC) remain unknown. The present study investigated the expression of the lncRNA GABPB1 intronic transcript (GABPB1‑IT1) in NSCLC tissues using publicly available databases. Subsequently, protein‑protein interaction (PPI) and co‑expression networks were constructed to identify key targets of lncRNA GABPB1‑IT1. Furthermore, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to investigate the potential roles of lncRNA GABPB1‑IT1. The current study identified that the expression of GABPB1‑IT1 was significantly downregulated in NSCLC samples compared with normal samples. Furthermore, the expression levels of GABPB1‑IT1 were lower in high grade NSCLC samples compared with low grade NSCLC samples. Additionally, overexpression of GABPB1‑IT1 in cancer samples was associated with improved survival of patients with NSCLC. GABPB1‑IT1 was revealed to be involved in the regulation of cell cycle‑associated biological processes, including sister chromatid cohesion, mitotic nuclear division, DNA replication, chromosome segregation, G1/S transition of mitotic cell cycle, mitotic cytokinesis and cell division. Finally, a GABPB1‑IT1‑associated protein‑protein interaction network was constructed for NSCLC. To the best of our knowledge, the present study was the first to demonstrate that GABPB1‑IT1 is associated with the prognosis of NSCLC. The current study provides useful information to assist with the investigation of potential candidate biomarkers for diagnosis, prognosis and drug targets for NSCLC.
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1 

Zamore PD and Haley B: Ribo-gnome: The big world of small RNAs. Science. 309:1519–1524. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Kornienko AE, Guenzl PM, Barlow DP and Pauler FM: Gene regulation by the act of long non-coding RNA transcription. BMC Biol. 11:592013. View Article : Google Scholar : PubMed/NCBI

3 

Wan X, Huang W, Yang S, Zhang Y, Pu H, Fu F, Huang Y, Wu H, Li T and Li Y: Identification of androgen-responsive lncRNAs as diagnostic and prognostic markers for prostate cancer. Oncotarget. 7:60503–60518. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Shi X, Sun M, Liu H, Yao Y and Song Y: Long non-coding RNAs: A new frontier in the study of human diseases. Cancer Lett. 339:159–166. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Zhang H, Chen Z, Wang X, Huang Z, He Z and Chen Y: Long non-coding RNA: A new player in cancer. J Hematol Oncol. 6:372013. View Article : Google Scholar : PubMed/NCBI

6 

Hauptman N and Glavač D: Long non-coding RNA in cancer. Int J Mol Sci. 14:4655–4669. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Ferreira LB, Palumbo A, de Mello KD, Sternberg C, Caetano MS, de Oliveira FL, Neves AF, Nasciutti LE, Goulart LR and Gimba ERP: PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling. BMC Cancer. 12:5072012. View Article : Google Scholar : PubMed/NCBI

8 

Luo Y, Wang C, Yong P, Ye P, Liu Z, Fu Z, Lu F, Xiang W, Tan W and Xiao J: Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer. Oncotarget. 8:112530–112549. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Sun ZQ, Chen C, Zhou QB, Liu JB, Yang SX, Li Z, Ou CL, Sun XT, Wang GX, Song JM, et al: Long non-coding RNA LINC00959 predicts colorectal cancer patient prognosis and inhibits tumor progression. Oncotarget. 8:97052–97060. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Sun S, Schiller JH and Gazdar AF: Lung cancer in Never-Smokers: A different disease. Nat Rev Cancer. 7:778–790. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Stewart B and Wild CP: World cancer report. 2014:Health. 2017.

12 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Herbst RS, Morgensztern D and Boshoff C: The biology and management of non-small cell lung cancer. Nature. 553:446–454. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Brennan P, Hainaut P and Boffetta P: Genetics of lung-cancer susceptibility. Lancet Oncol. 12:399–408. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Lu Q, Shan S, Li Y, Zhu D, Jin W and Ren T: Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p. FASEB J. 32:3957–3967. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Li C, Wan L, Liu Z, Xu G, Wang S, Su Z, Zhang Y, Zhang C, Liu X and Lei Z: Long non-coding RNA XIST promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-367/141-ZEB2 axis in non-small-cell lung cancer. Cancer Lett. 418:185–195. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Lai IL, Yang CA, Lin PC, Chan WL, Lee YT, Yen JC, Chang YS and Chang JG: Long noncoding RNA MIAT promotes non-small cell lung cancer proliferation and metastasis through MMP9 activation. Oncotarget. 8:98148–98162. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Cancer Genome Atlas Research Network, ; Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, et al: Integrated genomic characterization of endometrial carcinoma. Nature. 497:67–73. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Rami-Porta R, Ball D, Crowley J, Giroux DJ, Jett J, Travis WD, Tsuboi M, Vallieres E, Goldstraw P, Committee IS, et al: The IASLC lung cancer staging project: Proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thoracic Oncol. 2:593–602. 2007. View Article : Google Scholar

20 

Győrffy B, Surowiak P, Budczies J and Lánczky A: Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. PLoS One. 8:e822412013. View Article : Google Scholar : PubMed/NCBI

21 

Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, et al: The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39:D561–D568. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

24 

Assenov Y, Ramirez F, Schelhorn SE, Lengauer T and Albrecht M: Computing topological parameters of biological networks. Bioinformatics. 24:282–284. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Luo Y, Xuan Z, Zhu X, Zhan P and Wang Z: Long non-coding RNAs RP5-821D11. 7, APCDD1L-AS1 and RP11-277P12. 9 were associated with the prognosis of lung squamous cell carcinoma. Mol Med Rep. 17:7238–7248. 2018.PubMed/NCBI

26 

Yu T, Zhao Y, Hu Z, Li J, Chu D, Zhang J, Li Z, Chen B, Zhang X, Pan H, et al: MetaLnc9 facilitates lung cancer metastasis via a PGK1-activated AKT/mTOR pathway. Cancer Res. 77:5782–5794. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Liu J, Liu L, Wan JX and Song Y: Long noncoding RNA SNHG20 promotes gastric cancer progression by inhibiting p21 expression and regulating the GSK-3β/β-catenin signaling pathway. Oncotarget. 8:80700–80708. 2017.PubMed/NCBI

28 

Ma C, Wu G, Zhu Q, Liu H, Yao Y, Yuan D, Liu Y, Lv T and Song Y: Long intergenic noncoding RNA 00673 promotes non-small-cell lung cancer metastasis by binding with EZH2 and causing epigenetic silencing of HOXA5. Oncotarget. 8:326962017.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xie J, Xie G, Chen Q, Xu Z, Bai W and Chen M: Identification of a novel lncRNA GABPB1‑IT1 that is downregulated and predicts a poor prognosis in non‑small cell lung cancer. Oncol Lett 18: 838-845, 2019.
APA
Xie, J., Xie, G., Chen, Q., Xu, Z., Bai, W., & Chen, M. (2019). Identification of a novel lncRNA GABPB1‑IT1 that is downregulated and predicts a poor prognosis in non‑small cell lung cancer. Oncology Letters, 18, 838-845. https://doi.org/10.3892/ol.2019.10357
MLA
Xie, J., Xie, G., Chen, Q., Xu, Z., Bai, W., Chen, M."Identification of a novel lncRNA GABPB1‑IT1 that is downregulated and predicts a poor prognosis in non‑small cell lung cancer". Oncology Letters 18.1 (2019): 838-845.
Chicago
Xie, J., Xie, G., Chen, Q., Xu, Z., Bai, W., Chen, M."Identification of a novel lncRNA GABPB1‑IT1 that is downregulated and predicts a poor prognosis in non‑small cell lung cancer". Oncology Letters 18, no. 1 (2019): 838-845. https://doi.org/10.3892/ol.2019.10357
Copy and paste a formatted citation
x
Spandidos Publications style
Xie J, Xie G, Chen Q, Xu Z, Bai W and Chen M: Identification of a novel lncRNA GABPB1‑IT1 that is downregulated and predicts a poor prognosis in non‑small cell lung cancer. Oncol Lett 18: 838-845, 2019.
APA
Xie, J., Xie, G., Chen, Q., Xu, Z., Bai, W., & Chen, M. (2019). Identification of a novel lncRNA GABPB1‑IT1 that is downregulated and predicts a poor prognosis in non‑small cell lung cancer. Oncology Letters, 18, 838-845. https://doi.org/10.3892/ol.2019.10357
MLA
Xie, J., Xie, G., Chen, Q., Xu, Z., Bai, W., Chen, M."Identification of a novel lncRNA GABPB1‑IT1 that is downregulated and predicts a poor prognosis in non‑small cell lung cancer". Oncology Letters 18.1 (2019): 838-845.
Chicago
Xie, J., Xie, G., Chen, Q., Xu, Z., Bai, W., Chen, M."Identification of a novel lncRNA GABPB1‑IT1 that is downregulated and predicts a poor prognosis in non‑small cell lung cancer". Oncology Letters 18, no. 1 (2019): 838-845. https://doi.org/10.3892/ol.2019.10357
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