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Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients

  • Authors:
    • Xin Mu
    • Ou Huang
    • Min Jiang
    • Zuoquan Xie
    • Debo Chen
    • Xi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China, Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China, Division of Anti‑tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200025, P.R. China, Department of Breast Oncology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, P.R. China
    Copyright: © Mu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 742-750
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    Published online on: May 17, 2019
       https://doi.org/10.3892/ol.2019.10363
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Abstract

The roles of Ephrin B (EphB) receptors in cancer are relatively unknown as these receptors are associated with complex signaling pathways. A limited number of studies have investigated the association between EphB receptors and prognosis. Using the Kaplan‑Meier plotter database, the present study investigated the associations between the mRNA expression levels of five EphB receptors and the outcomes of 3,554 patients with breast cancer who had been followed‑up for 20 years. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated to assess the relative risk of survival. The results demonstrated that high mRNA expression levels of EphB2 (HR, 0.74; 95% CI, 0.66‑0.84; P=2.1x10‑6), EphB4 (HR, 0.82; 95% CI, 0.72‑0.93; P=0.0023) and EphB6 (HR, 0.69; 95% CI, 0.61‑0.78; P=3x10‑9) were significantly associated with improved survival, while a high mRNA expression level of EphB3 (HR, 1.14; 95% CI, 1.01‑1.28; P=0.029) was associated with worse survival for patients with breast cancer. High expression levels of all EphB receptors, including EphB1 (HR, 1.4; 95% CI, 1.02‑1.94; P=0.039), EphB2 (HR, 1.34; 95% CI, 1.07‑1.67; P=0.011), EphB3 (HR, 1.39; 95% CI, 1.11‑1.73, P=0.0038), EphB4 (HR, 1.33; 95% CI, 1.06‑1.67; P=0.013) and EphB6 (HR, 1.32; 95% CI, 1.05‑1.65; P=0.016), were associated with an increased risk of mortality in patients with lymph‑node‑positive breast cancer. High mRNA expression levels of EphB1 were not associated with survival for all patients with breast cancer (HR, 0.85; 95% CI, 0.72‑1.01; P=0.058). The results of the present suggested that EphB receptors may be useful as prognostic biomarkers of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Mu X, Huang O, Jiang M, Xie Z, Chen D and Zhang X: Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients. Oncol Lett 18: 742-750, 2019.
APA
Mu, X., Huang, O., Jiang, M., Xie, Z., Chen, D., & Zhang, X. (2019). Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients. Oncology Letters, 18, 742-750. https://doi.org/10.3892/ol.2019.10363
MLA
Mu, X., Huang, O., Jiang, M., Xie, Z., Chen, D., Zhang, X."Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients". Oncology Letters 18.1 (2019): 742-750.
Chicago
Mu, X., Huang, O., Jiang, M., Xie, Z., Chen, D., Zhang, X."Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients". Oncology Letters 18, no. 1 (2019): 742-750. https://doi.org/10.3892/ol.2019.10363
Copy and paste a formatted citation
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Spandidos Publications style
Mu X, Huang O, Jiang M, Xie Z, Chen D and Zhang X: Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients. Oncol Lett 18: 742-750, 2019.
APA
Mu, X., Huang, O., Jiang, M., Xie, Z., Chen, D., & Zhang, X. (2019). Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients. Oncology Letters, 18, 742-750. https://doi.org/10.3892/ol.2019.10363
MLA
Mu, X., Huang, O., Jiang, M., Xie, Z., Chen, D., Zhang, X."Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients". Oncology Letters 18.1 (2019): 742-750.
Chicago
Mu, X., Huang, O., Jiang, M., Xie, Z., Chen, D., Zhang, X."Prognostic value of ephrin B receptors in breast cancer: An online survival analysis using the microarray data of 3,554 patients". Oncology Letters 18, no. 1 (2019): 742-750. https://doi.org/10.3892/ol.2019.10363
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