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DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer

  • Authors:
    • Zhiling Yu
    • Qiuping Xu
    • Guixue Wang
    • Molly Rowe
    • Cameron Driskell
    • Qian Xie
    • Minhong Wu
    • Dongyu Jia
  • View Affiliations / Copyright

    Affiliations: Department of Urinary Surgery, The People's Hospital of Yichun City, Yichun, Jiangxi 336000, P.R. China, Morphism Institute, Seattle, WA 98117, USA, Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, P.R. China, Department of Biology, Georgia Southern University, Statesboro, GA 30460, USA
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 518-528
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    Published online on: May 17, 2019
       https://doi.org/10.3892/ol.2019.10365
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Abstract

Cancer is essentially a genetic disease. Accumulated gene mutations accelerate genome instability, which eventually leads to uncontrollable growth of the tumor. Bladder cancer is the most common form of urinary tract cancer. This form of cancer has a poor prognosis due to its clinical heterogeneity and molecular diversity. Despite recent scientific advances, the knowledge and treatment of bladder cancer still lags behind that of other types of solid tumor. In the present study, available large data portals and other studies were used to obtain clinically relevant information, and the data were systematically processed to decipher the genes associated with bladder cancer. Genes associated with the survival time of patients with bladder cancer were successfully identified. The genes were enriched in common biological processes and pathways, and upregulated in tumor samples from patients. Among the top genes identified as associated with good or poor survival in bladder cancer, DNA topoisomerase IIα (TOP2α) and RAD21 cohesin complex component (RAD21) were also increased in bladder cancer tissues and cell lines. Therefore, TOP2α and RAD21 could be used as potential therapeutic targets in bladder cancer.
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1 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Vogelstein B and Kinzler KW: Cancer genes and the pathways they control. Nat Med. 10:789–799. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Knudson AG: Two genetic hits (more or less) to cancer. Nat Rev Cancer. 1:157–162. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV, et al: An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics. Cell. 173:400–416.e11. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Cheung G, Sahai A, Billia M, Dasgupta P and Khan MS: Recent advances in the diagnosis and treatment of bladder cancer. BMC Med. 11:132013. View Article : Google Scholar : PubMed/NCBI

6 

Hurst CD and Knowles MA: Bladder cancer: Multi-omic profiling refines the molecular view. Nat Rev Clin Oncol. 15:203–204. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Cancer Genome Atlas Research Network, . Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 507:315–322. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, et al: Comprehensive molecular characterization of muscle-invasive bladder cancer. Cell. 171:540–556.e25. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Gentles AJ, Newman AM, Liu CL, Bratman SV, Feng W, Kim D, Nair VS, Xu Y, Khuong A, Hoang CD, et al: The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med. 21:938–945. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Jia D, Liu Z, Deng N, Tan TZ, Huang RY, Taylor-Harding B, Cheon DJ, Lawrenson K, Wiedemeyer WR, Walts AE, et al: A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets. Cancer Lett. 382:203–214. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

13 

Shin G, Kang TW, Yang S, Baek SJ, Jeong YS and Kim SY: GENT: Gene expression database of normal and tumor tissues. Cancer Inform. 10:149–157. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, et al: The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 483:603–607. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Taylor AB and MacKinnon DP: Four applications of permutation methods to testing a single-mediator model. Behav Res Methods. 44:806–844. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Mjelle R, Hegre SA, Aas PA, Slupphaug G, Drabløs F, Saetrom P and Krokan HE: Cell cycle regulation of human DNA repair and chromatin remodeling genes. DNA Repair (Amst). 30:53–67. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Park JE, Yi H, Kim Y, Chang H and Kim VN: Regulation of Poly(A) tail and translation during the somatic cell cycle. Mol Cell. 62:462–471. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Simon R, Atefy R, Wagner U, Forster T, Fijan A, Bruderer J, Wilber K, Mihatsch MJ, Gasser T and Sauter G: HER-2 and TOP2A coamplification in urinary bladder cancer. Int J Cancer. 107:764–772. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Zuiverloon TCM, de Jong FC, Costello JC and Theodorescu D: Systematic review: Characteristics and preclinical uses of bladder cancer cell lines. Bladder Cancer. 4:169–183. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Dinney CP, Fishbeck R, Singh RK, Eve B, Pathak S, Brown N, Xie B, Fan D, Bucana CD, Fidler IJ, et al: Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice. J Urol. 154:1532–1538. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Morales C and Losada A: Establishing and dissolving cohesion during the vertebrate cell cycle. Curr Opin Cell Biol. 52:51–57. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Kaufman DS, Shipley WU and Feldman AS: Bladder cancer. Lancet. 374:239–249. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Als AB, Dyrskjøt L, von der Maase H, Koed K, Mansilla F, Toldbod HE, Jensen JL, Ulhøi BP, Sengeløv L, Jensen KM and Orntoft TF: Emmprin and survivin predict response and survival following cisplatin-containing chemotherapy in patients with advanced bladder cancer. Clin Cancer Res. 13:4407–4414. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Apolo AB, Vogelzang NJ and Theodorescu D: New and promising strategies in the management of bladder cancer. Am Soc Clin Oncol Educ Book. Jun 1–2015.(Epub ahead of print). doi: 10.14694/EdBook_AM.2015.35.105. View Article : Google Scholar : PubMed/NCBI

25 

Dyrskjøt L, Zieger K, Real FX, Malats N, Carrato A, Hurst C, Kotwal S, Knowles M, Malmström PU, de la Torre M, et al: Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: A multicenter validation study. Clin Cancer Res. 13:3545–3551. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Kim WJ, Kim EJ, Kim SK, Kim YJ, Ha YS, Jeong P, Kim MJ, Yun SJ, Lee KM, Moon SK, et al: Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer. Mol Cancer. 9:32010. View Article : Google Scholar : PubMed/NCBI

27 

Blaveri E, Simko JP, Korkola JE, Brewer JL, Baehner F, Mehta K, Devries S, Koppie T, Pejavar S, Carroll P and Waldman FM: Bladder cancer outcome and subtype classification by gene expression. Clin Cancer Res. 11:4044–4055. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Dobbin ZC, Katre AA, Steg AD, Erickson BK, Shah MM, Alvarez RD, Conner MG, Schneider D, Chen D and Landen CN: Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer. Oncotarget. 5:8750–8764. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Wang E: Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res. 55:2284–2292. 1995.PubMed/NCBI

30 

Gal A, Sjöblom T, Fedorova L, Imreh S, Beug H and Moustakas A: Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene. 27:1218–1230. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Cao QH, Liu F, Li CZ, Liu N, Shu M, Lin Y, Ding L and Xue L: Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer. BMC Cancer. 18:942018. View Article : Google Scholar : PubMed/NCBI

32 

Stine ZE, Walton ZE, Altman BJ, Hsieh AL and Dang CV: MYC, metabolism, and cancer. Cancer Discov. 5:1024–1039. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Järvinen TA and Liu ET: Topoisomerase IIalpha gene (TOP2A) amplification and deletion in cancer-more common than anticipated. Cytopathology. 14:309–313. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Aumayr K, Klatte T, Neudert B, Birner P, Shariat S, Schmidinger M, Susani M and Haitel A: HER2 and TOP2A gene amplification and protein expression in upper tract urothelial carcinomas. Pathol Oncol Res. 24:575–581. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Al-Kuraya K, Novotny H, Bavi P, Siraj AK, Uddin S, Ezzat A, Sanea NA, Al-Dayel F, Al-Mana H, Sheikh SS, et al: HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer. J Clin Pathol. 60:768–772. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Bofin AM, Ytterhus B and Hagmar BM: TOP2A and HER-2 gene amplification in fine needle aspirates from breast carcinomas. Cytopathology. 14:314–319. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Fasching PA, Weihbrecht S, Haeberle L, Gasparyan A, Villalobos IE, Ma Y, Ekici AB, Wachter DL, Hartmann A, Beckmann MW, et al: HER2 and TOP2A amplification in a hospital-based cohort of breast cancer patients: Associations with patient and tumor characteristics. Breast Cancer Res Treat. 145:193–203. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Martín-Subero JI, Harder L, Gesk S, Schoch R, Novo FJ, Grote W, Calasanz MJ, Schlegelberger B and Siebert R: Amplification of ERBB2, RARA, and TOP2A genes in a myelodysplastic syndrome transforming to acute myeloid leukemia. Cancer Genet Cytogenet. 127:174–176. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Murphy AJ, Hughes CA, Barrett C, Magee H, Loftus B, O'Leary JJ and Sheils O: Low-level TOP2A amplification in prostate cancer is associated with HER2 duplication, androgen resistance, and decreased survival. Cancer Res. 67:2893–2898. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Schaefer-Klein JL, Murphy SJ, Johnson SH, Vasmatzis G and Kovtun IV: Topoisomerase 2 alpha cooperates with androgen receptor to contribute to prostate cancer progression. PLoS One. 10:e01423272015. View Article : Google Scholar : PubMed/NCBI

41 

Champoux JJ: DNA topoisomerases: Structure, function, and mechanism. Annu Rev Biochem. 70:369–413. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci USA. 101:9309–9314. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Xia L, Wang M, Li H, Tang X, Chen F and Cui J: The effect of aberrant expression and genetic polymorphisms of Rad21 on cervical cancer biology. Cancer Med. May 24–2018.(Epub ahead of print). doi: 10.1002/cam4.1592. View Article : Google Scholar

44 

Ahn JH, Kim TJ, Lee JH and Choi JH: Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cells. Sci Rep. 7:90762017. View Article : Google Scholar : PubMed/NCBI

45 

Yamamoto G, Irie T, Aida T, Nagoshi Y, Tsuchiya R and Tachikawa T: Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. Virchows Arch. 448:435–441. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Tessitore A, Cicciarelli G, Del Vecchio F, Gaggiano A, Verzella D, Fischietti M, Vecchiotti D, Capece D, Zazzeroni F and Alesse E: MicroRNAs in the DNA damage/repair network and cancer. Int J Genomics. 2014:8202482014. View Article : Google Scholar : PubMed/NCBI

47 

Deb S, Xu H, Tuynman J, George J, Yan Y, Li J, Ward RL, Mortensen N, Hawkins NJ, McKay MJ, et al: RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas. Br J Cancer. 110:1606–1613. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu Z, Xu Q, Wang G, Rowe M, Driskell C, Xie Q, Wu M and Jia D: DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer. Oncol Lett 18: 518-528, 2019.
APA
Yu, Z., Xu, Q., Wang, G., Rowe, M., Driskell, C., Xie, Q. ... Jia, D. (2019). DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer. Oncology Letters, 18, 518-528. https://doi.org/10.3892/ol.2019.10365
MLA
Yu, Z., Xu, Q., Wang, G., Rowe, M., Driskell, C., Xie, Q., Wu, M., Jia, D."DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer". Oncology Letters 18.1 (2019): 518-528.
Chicago
Yu, Z., Xu, Q., Wang, G., Rowe, M., Driskell, C., Xie, Q., Wu, M., Jia, D."DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer". Oncology Letters 18, no. 1 (2019): 518-528. https://doi.org/10.3892/ol.2019.10365
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Z, Xu Q, Wang G, Rowe M, Driskell C, Xie Q, Wu M and Jia D: DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer. Oncol Lett 18: 518-528, 2019.
APA
Yu, Z., Xu, Q., Wang, G., Rowe, M., Driskell, C., Xie, Q. ... Jia, D. (2019). DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer. Oncology Letters, 18, 518-528. https://doi.org/10.3892/ol.2019.10365
MLA
Yu, Z., Xu, Q., Wang, G., Rowe, M., Driskell, C., Xie, Q., Wu, M., Jia, D."DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer". Oncology Letters 18.1 (2019): 518-528.
Chicago
Yu, Z., Xu, Q., Wang, G., Rowe, M., Driskell, C., Xie, Q., Wu, M., Jia, D."DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer". Oncology Letters 18, no. 1 (2019): 518-528. https://doi.org/10.3892/ol.2019.10365
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