Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases

  • Authors:
    • Nyimi Bushabu Fidele
    • Liu Bing
    • Yanfang Sun
    • Tianfu Wu
    • Yueyu Zheng
    • Yifang Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Oral Maxillofacial Head and Neck Oncology Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China
    Copyright: © Fidele et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 733-741
    |
    Published online on: May 17, 2019
       https://doi.org/10.3892/ol.2019.10367
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study reported the clinical outcomes of 35 patients with mandibular odontogenic keratocysts (OKCs) following treatment by radical resection and immediate defect reconstruction. Amongst 565 patients with OKCs that were treated between April 2003 and May 2015, 35 patients underwent segmental or marginal mandibulectomy. The use of radical resection was based on clinical and/or radiographic evidence of size, cortical perforation and subsequent soft tissue involvement, and on the history of previous recurrence of the same lesion. Recurrence, justifications of the main major factor for resection, and functional and cosmetic results of the patients following mandibular reconstruction were systematically evaluated. There were 26 OKCs in the mandibular molar‑ramus region, eight in the mandibular anterior‑premolar region and one in the mandibular molar‑ramus and anterior‑molar regions. Among the 35 patients, 20 had primary OKCs and 15 had recurrent OKCs. A total of 31 patients underwent segmental mandibulectomy, of which 28 were immediately reconstructed with a vascularized flap, whereas four patients underwent marginal mandibulectomy. The functional and cosmetic outcomes of patients were evaluated as satisfactory. The length of the follow‑up period ranged from 2 to 17 years following operation (average, 5.82 years). Recurrence was identified in one patient who had been treated with marginal mandibulectomy. In conclusion, the findings from the present study suggested that radical resection may be recommended for patients with OKCs and locally aggressive features. Immediate mandibular reconstruction with a vascularized flap may be a crucial part of this aggressive treatment method that may reduce OKCs‑associated morbidity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Speight PM and Takata T: New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: Odontogenic and maxillofacial bone tumours. Virchows Arch. 472:331–339. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Philipsen HP: Pathology and Genetics of Head and Neck Tumours. World Health Organization Classification of Tumours. Barnes L, Eveson JW, Reichart P and Sidransky D: IARC. (Lyon). 306–307. 2005.

3 

Peacock ZS: Controversies in oral and maxillofacial pathology. Oral Maxillofac Surg Clin North Am. 29:475–486. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Al-moraissi EA, Dahan AA, Alwadeai MS, Oginni FO, Al-jamali JM, Alkhutari AS, Al-Tairi NH, Almaweri AA and Al-Sanabani JS: What surgical treatment has the lowest recurrence rate following the management of keratocystic odontogenic tumor?: A large systematic review and meta-analysis. J Craniomaxillofac Surg. 45:131–144. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Pitak-Arnnop P, Chaine A, Oprean N, Dhanuthai K, Bertrand JC and Bertolus C: Management of odontogenic keratocysts of the jaws: A ten-year experience with 120 consecutive lesions. J Craniomaxillofac Surg. 38:358–364. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Chirapathomsakul D, Sastravaha P and Jansisyanont P: A review of odontogenic keratocysts and the behavior of recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 101:5–9. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Yagyuu T, Kirita T, Sasahira T, Moriwaka Y, Yamamoto K and Kuniyasu H: Recurrence of keratocystic odontogenic tumor: Clinicopathological features and immunohistochemical study of the Hedgehog signaling pathway. Pathobiology. 75:171–176. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Sánchez-Burgos R, González-Martín-Moro J, Pérez-Fernández E and Burgueño-García M: Clinical, radiological and therapeutic features of keratocystic odontogenic tumours: A study over a decade. J Clin Exp Dent. 6:e259–e264. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Al-Moraissi EA, Pogrel MA and Ellis E III: Enucleation with or without adjuvant therapy versus marsupialization with or without secondary enucleation in the treatment of keratocystic odontogenic tumors: A systematic review and meta-analysis. J Craniomaxillofaciac Surg. 44:1395–1403. 2016. View Article : Google Scholar

10 

Zecha JA, Mendes RA, Lindeboom VB and van der Waal I: Recurrence rate of keratocystic odontogenic tumor after conservative surgical treatment without adjunctive therapies-A 35-year single institution experience. Oral Oncol. 46:740–742. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Cunha JF, Gomes CC, de Mesquita RA, Andrade Goulart EM, de Castro WH and Gomez RS: Clinicopathologic features associated with recurrence of the odontogenic keratocyst: A cohort retrospective analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 121:629–635. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Pogrel MA and Jordan RC: Marsupialization as a definitive treatment for the odontogenic keratocyst. J Oral Maxillofac Surg. 62:651–655; discussion 655–656. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Mendes RA, Carvalho JF and van der Waal I: Characterization and management of the keratocystic odontogenic tumor in relation to its histopathological and biological features. Oral Oncol. 46:219–225. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Blanas N, Freund B, Schwartz M and Furst IM: Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 90:553–558. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Kolokythas A, Fernandes RP, Pazoki A and Ord RA: Odontogenic keratocyst: To decompress or not to decompress? A comparative study of decompression and enucleation versus resection/peripheral ostectomy. J Oral Maxillofac Surg. 65:640–644. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Worrall SF: Recurrent odontogenic keratocyst within the temporalis muscle. Br J Oral Maxillofac Surg. 30:59–62. 1992. View Article : Google Scholar : PubMed/NCBI

17 

Gosau M, Draenert FG, Müller S, Frerich B, Bürgers R, Reichert TE and Driemel O: Two modifications in the treatment of keratocystic odontogenic tumors (KCOT) and the use of carnoy's solution (CS)-a retrospective study lasting between 2 and 10 years. Clin Oral Investig. 14:27–34. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Jackson IT, Potparic Z, Fasching M, Schievink WI, Tidstrom K and Hussain K: Penetration of the skull base by dissecting keratocyst. J Craniomaxillofac Surg. 21:319–325. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Zhao YF, Wei JX and Wang SP: Treatment of odontogenic keratocysts: A follow-up of 255 Chinese patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 94:151–156. 2002. View Article : Google Scholar

20 

Stoelinga PJ: Long-term follow-up on keratocysts treated according to a defined protocol. Int J Oral Maxillofac Surg. 30:14–25. 2001. View Article : Google Scholar : PubMed/NCBI

21 

August M, Faquin WC, Troulis MJ and Kaban LB: Dedifferentiation of odontogenic keratocyst epithelium after cyst decompression. J Oral Maxillofac Surg. 61:678–683; discussion 683–684. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Chrcanovic BR and Gomez RS: Recurrence probability for keratocystic odontogenic tumors: An analysis of 6427 cases. J Craniomaxillofac Surg. 45:244–251. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Sharif FN, Oliver R, Sweet C and Sharif MO: Interventions for the treatment of keratocystic odontogenic tumours. Cochrane Database Syst Rev CD008464. 2015. View Article : Google Scholar

24 

Liu B, Cai Y, Wang SP and Zhao YF: Recurrent keratocystic odontogenic tumor in the masseter muscle overlying the boney perforations: A case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 113:e1–e5. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Stoelinga PJ: Etiology and pathogenesis of keratocysts. Oral Maxillofac Surg Clin North Am. 15:317–324. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Warburton G, Shihabi A and Ord RA: Keratocystic odontogenic tumor (KCOT/OKC)-clinical guidelines for resection. J Maxillofac Oral Surg. 14:558–564. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Myoung H, Hong SP, Hong SD, Lee JI, Lim CY, Choung PH, Lee JH, Choi JY, Seo BM and Kim MJ: Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 91:328–333. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Giuliani M, Grossi GB, Lajolo C, Bisceglia M and Herb KE: Conservative management of a large odontogenic keratocyst: Report of a case and review of the literature. J Oral Maxillofac Surg. 64:308–316. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Ahlfors E, Larsson A and Sjögren S: The odontogenic keratocyst: A benign cystic tumour? J Oral Maxillofac Surg. 42:10–19. 1984. View Article : Google Scholar : PubMed/NCBI

30 

Stoelinga PJ and Bronkhorst FB: The incidence, multiple presentation and recurrence of aggressive cysts of the jaws. J Craniomaxillofac Surg. 16:184–195. 1988. View Article : Google Scholar : PubMed/NCBI

31 

Boyne PJ, Hou D, Moretta C and Pritchard T: The multifocal nature of odontogenic keratocysts. J Calif Dent Assoc. 33:961–965. 2005.PubMed/NCBI

32 

Hidalgo DA and Pusic AL: Free-flap mandibular reconstruction: A 10-year follow-up study. Plast Reconstr Surg. 110:438–449; discussion 450–451. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Lyons AJ, James R and Collyer J: Free vascularised iliac crest graft: An audit of 26 consecutive cases. Br J Oral Maxillofac Surg. 43:210–214. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fidele NB, Bing L, Sun Y, Wu T, Zheng Y and Zhao Y: Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases. Oncol Lett 18: 733-741, 2019.
APA
Fidele, N.B., Bing, L., Sun, Y., Wu, T., Zheng, Y., & Zhao, Y. (2019). Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases. Oncology Letters, 18, 733-741. https://doi.org/10.3892/ol.2019.10367
MLA
Fidele, N. B., Bing, L., Sun, Y., Wu, T., Zheng, Y., Zhao, Y."Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases". Oncology Letters 18.1 (2019): 733-741.
Chicago
Fidele, N. B., Bing, L., Sun, Y., Wu, T., Zheng, Y., Zhao, Y."Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases". Oncology Letters 18, no. 1 (2019): 733-741. https://doi.org/10.3892/ol.2019.10367
Copy and paste a formatted citation
x
Spandidos Publications style
Fidele NB, Bing L, Sun Y, Wu T, Zheng Y and Zhao Y: Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases. Oncol Lett 18: 733-741, 2019.
APA
Fidele, N.B., Bing, L., Sun, Y., Wu, T., Zheng, Y., & Zhao, Y. (2019). Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases. Oncology Letters, 18, 733-741. https://doi.org/10.3892/ol.2019.10367
MLA
Fidele, N. B., Bing, L., Sun, Y., Wu, T., Zheng, Y., Zhao, Y."Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases". Oncology Letters 18.1 (2019): 733-741.
Chicago
Fidele, N. B., Bing, L., Sun, Y., Wu, T., Zheng, Y., Zhao, Y."Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases". Oncology Letters 18, no. 1 (2019): 733-741. https://doi.org/10.3892/ol.2019.10367
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team