Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non‑small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis

  • Authors:
    • Yi Liao
    • Xianming Fan
    • Xue Wang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
    Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 581-592
    |
    Published online on: May 20, 2019
       https://doi.org/10.3892/ol.2019.10373
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The surgical treatment of patients with advanced lung cancer remains controversial. The current study aimed to identify the factors affecting the prognosis of patients with stage IV non‑small cell lung cancer (NSCLC) and to clarify the surgery guidelines. A total of 27,725 patients diagnosed with stage IV NSCLC were selected from the Surveillance, Epidemiology, and End Results program between 2010 and 2013. The sex, age, ethnicity, marital status, Tumor‑Node‑Metastasis stage, radiation therapy received and surgical status of each patient were recorded. Patients were followed up to November 2015. Survival rates were estimated by the Kaplan‑Meier method. Single‑ and multi‑factor analyses were performed using the log‑rank test and multivariate Cox regression analysis respectively. In the isolated organ metastasis cohort, patients with liver metastasis alone had the worst prognosis, with a median overall survival (OS) of 4 months (liver metastasis vs. other organ metastases; P<0.001). Patients with lung metastasis only had the best prognosis, with a median OS of 8 months (lung metastasis vs. other organ metastases; P<0.001). Furthermore, patients with only one metastasis had the best prognosis, with a median OS of 6 months (single metastasis vs. multiple‑organ metastases; P<0.001). The multivariate Cox regression analysis of the isolated‑organ metastasis cohort and the multiple‑organ metastases cohort revealed that patients who were ≤60 years, female, married, Asian, with N0 stage, had only bone metastasis, accepted wedge resection or lobectomy of the primary tumor, had surgical procedure to distant lymph node(s), and received beam radiation had an improved prognosis compared with the other patients. Age, sex, tumor type, ethnicity, N stage, number and type of metastatic lesions, surgical treatment of primary and metastatic lesions and radiation therapy are factors which influence the prognosis of patients with stage IV NSCLC. Furthermore, surgery may still benefit these patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, et al: SEER Cancer Statistics Review, 1975–2015, National Cancer Institute. Bethesda, MD: 2018, https://seer.cancer.gov/archive/csr/1975_2015/September 10–2018

4 

Duan L, Pang HL, Chen WJ, Shen WW, Cao PP, Wang SM, Liu LL and Zhang HL: The role of GDF15 in bone metastasis of lung adenocarcinoma cells. Oncol Rep. 41:2379–2388. 2019.PubMed/NCBI

5 

Riihimäki M, Hemminki A, Fallah M, Thomsen H, Sundquist K, Sundquist J and Hemminki K: Metastatic sites and survival in lung cancer. Lung Cancer. 86:78–84. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Wang Y, Xie S and He B: Effect of EGFR gene polymorphism on efficacy of chemotherapy combined with targeted therapy for non-small cell lung cancer in Chinese patients. Am J Cancer Res. 9:619–627. 2019.PubMed/NCBI

7 

Sosa Iglesias V, Giuranno L, Dubois LJ, Theys J and Vooijs M: Drug resistance in non-small cell lung cancer: A potential for NOTCH Targeting? Front Oncol. 8:2672018. View Article : Google Scholar : PubMed/NCBI

8 

Kogure Y: Cost effectiveness and health economics of immune checkpoint inhibitors for non-small cell lung cancer. Gan To Kagaku Ryoho. 45:781–784. 2018.(In Japanese). PubMed/NCBI

9 

Skinner KE, Fernandes AW, Walker MS Pavilack M and VanderWalde A: Healthcare costs in patients with advanced non-small cell lung cancer and disease progression during targeted therapy: A real-world observational study. J Med Econ. 21:192–200. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Furák J, Troján I, Szöke T, Agócs L, Csekeö A, Kas J, Svastics E, Eller J and Tiszlavicz L: Lung cancer and its operable brain metastasis: Survival rate and staging problems. Ann Thorac Surg. 79:241–247. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Hanagiri T, Takenaka M, Oka S, Shigematsu Y, Nagata Y, Shimokawa H, Uramoto H and Tanaka F: Results of a surgical resection for patients with stage IV non-small-cell lung cancer. Clin Lung Cancer. 13:220–224. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Congedo MT, Cesario A, Lococo F, De Waure C, Apolone G, Meacci E, Cavuto S and Granone P: Surgery for oligometastatic non-small cell lung cancer: Long-term results from a single center experience. J Thorac Cardiovasc Surg. 144:444–452. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Tieqin L, Hongxu L, Yu L, Shun X and Chunlu Y: Influencing factors of survival rate on 44 cases of postoperative stage IV non-small-celllung cancer. Chin J Ciinicians (Eiectronic Ed). 7:605–608. 2013.

14 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Manual. (7th). Springer. (New York, NY). 2009.

15 

Delea T, Langer C, McKiernan J, Liss M, Edelsberg J, Brandman J, Sung J, Raut M and Oster G: The cost of treatment of skeletal-related events in patients with bone metastases from lung cancer. Oncology. 67:390–396. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Hofferberth SC, Grinstaff MW and Colson YL: Nanotechnology applications in thoracic surgery. Eur J Cardiothorac Surg. 50:6–16. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Vaughn C, Mychaskiw G II and Sewell P: Massive hemorrhage during radiofrequency ablation of a pulmonary neoplasm. Anesth Analg. 94:1149–1151. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Tutar N, Yurci A, Güneş I, Gülmez İ, Gürsoy Ş, Önal Ö and Canöz Ö: The role of endobronchial and endoscopic ultrasound guided fine needle aspiration for mediastinal nodal staging of non-small-cell lung cancer. Tuberk Toraks. 66:85–92. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Reck M and Rabe KF: Precision diagnosis and treatment for advanced non-small-cell lung cancer. N Engl J Med. 377:849–861. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Dong F, Shen Y, Gao F, Xu T, Wang X, Zhang X, Zhong S, Zhang M, Chen S and Shen Z: Prognostic value of site-specific metastases and therapeutic roles of surgery for patients with metastatic bladder cancer: A population-based study. Cancer Manag Res. 9:611–626. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Luo D, Liu Q, Yu W, Ma Y, Zhu J, Lian P, Cai S, Li Q and Li X: Prognostic value of distant metastasis sites and surgery in stage IV colorectal cancer: A population-based study. Int J Colorectal Dis. 33:1241–1249. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Tamura T, Kurishima K, Nakazawa K, Kagohashi K, Ishikawa H, Satoh H and Hizawa N: Specific organ metastases and survival in metastatic non-small-cell lung cancer. Mol Clin Oncol. 3:217–221. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Nakazawa K, Kurishima K, Tamura T, Kagohashi K, Ishikawa H, Satoh H and Hizawa N: Specific organ metastases and survival in small cell lung cancer. Oncol Lett. 4:617–620. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Yang J, Zhang Y, Sun X, Gusdon AM, Song N, Chen L, Jiang G and Huang Y: The prognostic value of multiorgan metastases in patients with non-small cell lung cancer and its variants: A SEER-based study. J Cancer Res Clin Oncol. 144:1835–1842. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Gibson AJW, Li H, D'Silva A, Tudor RA, Elegbede AA, Otsuka SM, Bebb DG and Cheung WY: Impact of number versus location of metastases on survival in stage IV M1b non-small cell lung cancer. Med Oncol. 35:1172018. View Article : Google Scholar : PubMed/NCBI

26 

Rami-Porta R, Bolejack V, Crowley J, Ball D, Kim J, Lyons G, Rice T, Suzuki K, Thomas CF Jr, Travis WD, et al: The IASLC lung cancer staging project: Proposals for the revisions of the T descriptors in the forthcoming eighth edition of the TNM classification for lung cancer. J Thorac Oncol. 10:990–1003. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Oweira H, Petrausch U, Helbling D, Schmidt J, Mannhart M, Mehrabi A, Schöb O, Giryes A, Decker M and Abdel-Rahman O: Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A Surveillance Epidemiology and End Results database analysis. World J Gastroenterol. 23:1872–1880. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Hidalgo M: Pancreatic cancer. N Engl J Med. 362:1605–1617. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Shi Y, Sun Y, Yu J, Ding C, Wang Z, Wang C, Wang D, Wang C, Wang Z, Wang M, et al: China experts consensus on the diagnosis and treatment of advanced stage primary lung cancer (2016 version). Asia Pac J Clin Oncol. 13:87–103. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Shi Y, Sun Y, Yu J, Ding C, Ma Z, Wang Z, Wang D, Wang Z, Wang M, Wang Y, et al: China experts consensus on the diagnosis and treatment of brain metastases of lung cancer (2017 version). Zhongguo Fei Ai Za Zhi. 20:1–13. 2017.(In Chinese). PubMed/NCBI

31 

Sun Y, Guan Z, Liao M, Yu X, Wang C, Wang J, Niu X, Shi Y, Zhi X, Liu Y, et al: Expert consensus on the diagnosis and treatment of bone metastasis in lung cancer (2014 version). Zhongguo Fei Ai Za Zhi. 17:57–72. 2014.(In Chinese). PubMed/NCBI

32 

Schmelzle M, Eisenberger CF, Am Esch JS II, Matthaei H, Krausch M and Knoefel WT: Non-colorectal, non-neuroendocrine, and non-sarcoma metastases of the liver: Resection as a promising tool in the palliative management. Langenbecks Arch Surg. 395:227–234. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Ileana E, Greillier L, Moutardier V and Barlesi F: Surgical resection of liver non-small cell lung cancer metastasis: A dual weapon? Lung Cancer. 70:221–222. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Di Carlo I, Grasso G, Patane' D, Russello D and Latteri F: Liver metastases from lung cancer: Is surgical resection justified? Ann Thorac Surg. 76:291–293. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Reddy SK, Barbas AS, Marroquin CE, Morse MA, Kuo PC and Clary BM: Resection of noncolorectal nonneuroendocrine liver metastases: A comparative analysis. J Am Coll Surg. 204:372–382. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Abdel-Rahman O: Outcomes of surgery as part of the management of metastatic Non-small-cell lung cancer: A Surveillance, epidemiology and End results database analysis. Cancer Invest. 36:238–245. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Liu K, Zheng D, Xu G, Du Z and Wu S: Local thoracic therapy improve prognosis for stage IV non-small cell lung cancer patients combined with chemotherapy: A Surveillance, Epidemiology, and End results database analysis. PLoS One. 12:e01873502017. View Article : Google Scholar : PubMed/NCBI

38 

Setzer M, Robinson LA and Vrionis FD: Management of locally advanced pancoast (superior sulcus) tumors with spine involvement. Cancer Control. 21:158–167. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Rui M, Pengqing Y and Chang C: Progress in resection and reconstruction of chest wall in non-small lung cancer. Chin J Clin Thorac Cardiovasc Surg. 22:685–690. 2015.

40 

Dai C, Shen J, Ren Y, Zhong S, Zheng H, He J, Xie D, Fei K, Liang W, Jiang G, et al: Choice of surgical procedure for patients with Non-small-cell lung cancer ≤1 cm or >1 to 2 cm among lobectomy, segmentectomy, and wedge resection: A population-based study. J Clin Oncol. 34:3175–3182. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Ludwig MS, Goodman M, Miller DL and Johnstone PA: Postoperative survival and the number of lymph nodes sampled during resection of node-negative non-small cell lung cancer. Chest. 128:1545–1550. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Zhang R, Li P, Li Q, Qiao Y, Xu T, Ruan P, Song Q and Fu Z: Radiotherapy improves the survival of patients with stage IV NSCLC: A propensity score matched analysis of the SEER database. Cancer Med. 7:5015–5026. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Herskovic A, Chitti B, Christos P, Wernicke AG and Parashar B: Addition of surgery after radiation significantly improves survival in stage IIIB Non-small cell lung cancer: A population-based analysis. World J Surg. 41:758–762. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Verma V, Rwigema JM, Adeberg S and Simone CB II: Enrollment of elderly patients with locally advanced non-small cell lung cancer in multi-institutional trials of proton beam radiation therapy. Clin Lung Cancer. 18:441–443. 2017. View Article : Google Scholar : PubMed/NCBI

45 

He M, Li S, Chen Y, Ouyang M, Chen P and Zhang J: 131I-chTNT injection to relieve tracheal obstruction in advanced NSCLC patient. Technol Health Care. 24 (Suppl 2):S513–S519. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Hendriks LE, Hermans BC, van den Beuken-van Everdingen MH, Hochstenbag MM and Dingemans AM: Effect of Bisphosphonates, Denosumab, and radioisotopes on bone pain and quality of life in patients with non-small cell lung cancer and bone metastases: A systematic review. J Thorac Oncol. 11:155–173. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Toffart AC, Duruisseaux M, Brichon PY, Pirvu A, Villa J, Selek L, Guillem P, Dumas I, Ferrer L, Levra MG and Moro-Sibilot D: Operation and chemotherapy: Prognostic factors for lung cancer with one synchronous metastasis. Ann Thorac Surg. 105:957–965. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Cheng TD, Darke AK, Redman MW, Zirpoli GR, Davis W, Payne Ondracek R, Bshara W, Omilian AR, Kratzke R, Reid ME, et al: Smoking, Sex, and Non-small cell lung cancer: Steroid hormone receptors in tumor tissue (S0424). J Natl Cancer Inst. 110:734–742. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Merrill RM and Johnson E: Benefits of marriage on relative and conditional relative cancer survival differ between males and females in the USA. J Cancer Surviv. 11:578–589. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Wu Y, Ai Z and Xu G: Marital status and survival in patients with non-small cell lung cancer: An analysis of 70006 patients in the SEER database. Oncotarget. 8:103518–103534. 2017.PubMed/NCBI

51 

Richards TB, Henley SJ, Puckett MC, Weir HK, Huang B, Tucker TC and Allemani C: Lung cancer survival in the United States by race and stage (2001–2009): Findings from the CONCORD-2 study. Cancer. 123:5079–5099. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Williams CD, Salama JK, Moghanaki D, Karas TZ and Kelley MJ: Impact of race on treatment and survival among U.S. Veterans with early-stage lung cancer. J Thorac Oncol. 11:1672–1681. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Videtic GM, Reddy CA, Chao ST, Rice TW, Adelstein DJ, Barnett GH, Mekhail TM, Vogelbaum MA and Suh JH: Gender, race, and survival: A study in non-small-cell lung cancer brain metastases patients utilizing the radiation therapy oncology group recursive partitioning analysis classification. Int J Radiat Oncol Biol Phys. 75:1141–1147. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Tannenbaum SL, Koru-Sengul T, Zhao W, Miao F and Byrne MM: Survival disparities in non-small cell lung cancer by race, ethnicity, and socioeconomic status. Cancer J. 20:237–245. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Yoshinaga Y, Enatsu S, Iwasaki A and Shirakusa T: Surgical treatment for primary non-small cell lung cancer with synchronous brain metastases. Kyobu Geka. 59:41–45. 2016.(In Japanese).

56 

Ramalingam S, Dinan MA and Crawford J: Survival comparison in patients with Stage IV lung cancer in Academic versus Community centers in the United States. J Thorac Oncol. 13:1842–1850. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Xiaolan J and Jia W: Prognostic factors for bone metastasis of patients with non-small-cell lung cancer. Shandong Med. 56:88–90. 2016.

58 

Masters GA, Temin S, Azzoli CG, Giaccone G, Baker S Jr, Brahmer JR, Ellis PM, Gajra A, Rackear N, Schiller JH, et al: Systemic therapy for stage IV non-small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 33:3488–3515. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Zhang YL, Yuan JQ, Wang KF, Fu XH, Han XR, Threapleton D, Yang ZY, Mao C and Tang JL: The prevalence of EGFR mutation in patients with non-small cell lung cancer: A systematic review and meta-analysis. Oncotarget. 7:78985–78993. 2016.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liao Y, Fan X and Wang X: Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non‑small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis. Oncol Lett 18: 581-592, 2019.
APA
Liao, Y., Fan, X., & Wang, X. (2019). Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non‑small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis. Oncology Letters, 18, 581-592. https://doi.org/10.3892/ol.2019.10373
MLA
Liao, Y., Fan, X., Wang, X."Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non‑small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis". Oncology Letters 18.1 (2019): 581-592.
Chicago
Liao, Y., Fan, X., Wang, X."Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non‑small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis". Oncology Letters 18, no. 1 (2019): 581-592. https://doi.org/10.3892/ol.2019.10373
Copy and paste a formatted citation
x
Spandidos Publications style
Liao Y, Fan X and Wang X: Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non‑small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis. Oncol Lett 18: 581-592, 2019.
APA
Liao, Y., Fan, X., & Wang, X. (2019). Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non‑small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis. Oncology Letters, 18, 581-592. https://doi.org/10.3892/ol.2019.10373
MLA
Liao, Y., Fan, X., Wang, X."Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non‑small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis". Oncology Letters 18.1 (2019): 581-592.
Chicago
Liao, Y., Fan, X., Wang, X."Effects of different metastasis patterns, surgery and other factors on the prognosis of patients with stage IV non‑small cell lung cancer: A Surveillance, Epidemiology, and End Results (SEER) linked database analysis". Oncology Letters 18, no. 1 (2019): 581-592. https://doi.org/10.3892/ol.2019.10373
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team