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Article

Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma

  • Authors:
    • Kyoko Oura
    • Koji Fujita
    • Asahiro Morishita
    • Hisakazu Iwama
    • Mai Nakahara
    • Tomoko Tadokoro
    • Teppei Sakamoto
    • Takako Nomura
    • Hirohito Yoneyama
    • Shima Mimura
    • Joji Tani
    • Hideki Kobara
    • Keiichi Okano
    • Yasuyuki Suzuki
    • Tsutomu Masaki
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Neurology, Kagawa University, Miki 761‑0793, Japan, Life Science Research Center, Kagawa University, Miki 761‑0793, Japan, Department of Gastroenterological Surgery, Kagawa University, Miki 761‑0793, Japan
  • Pages: 882-890
    |
    Published online on: May 21, 2019
       https://doi.org/10.3892/ol.2019.10385
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Abstract

During diagnosis of early stage hepatocellular carcinoma (HCC), single or small lesions are difficult to identify using screening ultrasonography, and conventional tumor markers are frequently negative. MicroRNAs (miRNAs) are small non‑coding RNAs that suppress the translation of target mRNAs and exert significance as biomarkers. The aim of the present study was to use samples of patients with HCC and those with other liver diseases caused by hepatitis C virus (HCV) infection to investigate the expression profile of serum miRNAs, and identify a miRNA that can serve as a HCC biomarker. Initially, changes in 2,555 miRNAs between pre‑ and post‑curative treatment serum from 12 patients with early stage HCC were examined using microarray analysis. The serum levels of miR‑125a‑5p in 40 individuals with HCV‑associated chronic hepatitis (CH), liver cirrhosis (LC) or HCC were measured using reverse transcription‑quantitative polymerase chain reaction, and 5 miRNAs, including miR‑125a‑5p, miR‑423‑5p, miR‑1247, miR‑1304 and miR‑3648, were identified to be downregulated following curative treatment in patients with HCC. Among these, miR‑125a‑5p was identified to be similarly decreased following treatment in all patients. Additionally, the expression levels of miR‑125a‑5p were significantly upregulated in patients with HCC in the early and advanced stages of disease, compared with patients with CH or LC (P<0.05). Serum miR‑125a‑5p fluctuates depending on the presence of HCC, and may serve as a noninvasive biomarker to aid in diagnosing early carcinogenesis in HCV‑associated chronic liver diseases.
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1 

McGlynn KA and London WT: The global epidemiology of hepatocellular carcinoma: Present and future. Clin Liver Dis. 15:223–243. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Forner A, Llovet JM and Bruix J: Hepatocellular carcinoma. Lancet. 379:1245–1255. 2012. View Article : Google Scholar : PubMed/NCBI

3 

El-Seraq HB: Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 142:1264–1273.e1. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Yoeman AD, Al-Chalabi T, Karani JB, Quaglia A, Devlin J, Mieli-Vergani G, Bomford A, O'Grady JG, Harrison PM and Heneghan MA: Evaluation of risk factors in the development of hepatocellular carcinoma in autoimmune hepatitis: Implications for follow-up and screening. Hepatology. 48:863–870. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Zhang W, He H, Zang M, Wu Q, Zhao H, Lu LL, Ma P, Zheng H, Wang N, Zhang Y, et al: Genetic features of aflatoxin-associated hepatocellular carcinoma. Gastroenterology. 153:249–262.e2. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Altekruse SF, Henley SJ, Cucinelli JE and McGlynn KA: Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States. Am J Gastroenterol. 109:542–553. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Kim SR, Kudo M, Hino O, Han KH, Chung YH and Lee HS; Organizing Committee of Japan-Korea Liver Symposium, : Epidemiology of hepatocellular carcinoma in Japan and Korea. A review. Oncology. 75 (Suppl 1):S13–S16. 2008. View Article : Google Scholar

8 

Murakami T, Kim T, Oi H, Nakamura H, Igurashi H, Matsushita M, Okamura J and Kozuka T: Detectability of hypervascular hepatocellular carcinoma by arterial phase images of MR and spiral CT. Acta Radiol. 36:372–376. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Park SJ, Jang JY, Jeong SW, Cho YK, Lee SH, Kim SG, Cha SW, Kim YS, Cho YD, Kim HS, et al: Usefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma. Medicine (Baltimore). 96:e58112017. View Article : Google Scholar : PubMed/NCBI

10 

Tomimaru Y, Eguchi H, Nagano H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Tomokuni A, Takemasa I, Umeshita K, et al: Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. J Hepatol. 56:167–175. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Esquela-Kerscher A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Carleton M, Cleary MA and Linsley PS: MicroRNAs and cell cycle regulation. Cell Cycle. 6:2127–2132. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Harfe BD: MicroRNAs in vertebrate development. Curr Opin Genet Dev. 15:410–415. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Garzon R, Calin GA and Croce CM: MicroRNA in cancer. Annu Rev Med. 60:167–179. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Melo SA and Esteller M: Dysregulation of microRNAs in cancer: Playing with fire. FEBS Lett. 585:2087–2099. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Osaki M, Takeshita F and Ochiya T: MicroRNAs as biomarkers and therapeutic drugs in human cancer. Biomarkers. 13:658–670. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A, Zanetti KA, Ye QH, Qin LX, Croce CM, et al: Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology. 47:897–907. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Morishita A, Iwama H, Fujihara S, Sakamoto T, Fujita K, Tani J, Miyoshi H, Yoneyama H, Himoto T and Masaki T: MicroRNA profiles in various hepatocellular carcinoma cell lines. Oncol Lett. 12:1687–1692. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Morishita A and Masaki T: MicroRNAs as possible biomarkers for hepatocellular carcinoma. Hepatol Res. 48:499–501. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Gibbings DJ, Ciaudo C, Erhardt M and Voinnet O: Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat Cell Biol. 11:1143–1149. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Yin C, Zhou X, Yan J and Zhang G: Potential role of circulating miR-21 in the diagnosis and prognosis of digestive system cancer: A systematic review and meta-analysis. Medicine (Baltimore). 94:e21232015. View Article : Google Scholar : PubMed/NCBI

23 

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:10513–10518. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Liver Cancer Study Group of Japan. In, . General rules for the clinical and pathological study of primary liver cancer. 3rd. Tokyo, Kanehara: 2010

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Method. 25:402–408. 2001. View Article : Google Scholar

26 

Ogata-Kagata H, Izumiya M, Kurioka D, Honma Y, Yamada Y, Furuta K, Gunji T, Ohta H, Okamoto H, Soneda H, et al: Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS One. 9:e929212014. View Article : Google Scholar : PubMed/NCBI

27 

Que R, Ding G, Chen J and Cao L: Analysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinoma. World J Surg Oncol. 11:2192013. View Article : Google Scholar : PubMed/NCBI

28 

Taylor DD and Gercel-Talor C: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol. 110:13–21. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Wang J, Zhou Y, Lu J, Sun Y, Xiao H, Liu M and Taian L: Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma. Med Oncol. 31:1482014. View Article : Google Scholar : PubMed/NCBI

30 

Wang H, Hou L, Li A, Duan Y, Gao H and Song X: Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. Biomed Res Int. 2014:8648942014.PubMed/NCBI

31 

Sugimachi K, Matsumura T, Hirata H, Uchi R, Ueda M, Ueo H, Shinden Y, Iguchi H, Eguchi H, Shirabe K, et al: Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. Br J Cancer. 112:532–538. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Y, Gao JS, Tang X, Tucker LD, Quesenberry P, Rigoutsos I and Ramratnam B: MicroRNA 125a and its regulation of the p53 tumor suppressor gene. FEBS Lett. 583:3725–3730. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Wu S, Huang S, Ding J, Zhao Y, Liang L, Liu T, Zhan R and He X: Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region. Oncogene. 29:2302–2308. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS and Benz CC: Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem. 282:1479–1486. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Tang H, Li RP, Liang P, Zhou YL and Wang GW: miR-125a inhibits the migration and invasion of liver cancer cells via suppression of the PI3K/AKT/mTOR signaling pathway. Oncol Lett. 10:681–686. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Li G, Zhang W, Gong L and Huang X: MicroRNA-125a-5p inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma by downregulation of ErbB3. Oncol Res. 27:449–458. 2019. View Article : Google Scholar : PubMed/NCBI

37 

O'Day E and Lal A: MicroRNAs and their target gene in breast cancer. Breast Cancer Res. 12:2012010. View Article : Google Scholar : PubMed/NCBI

38 

Nam EJ, Yoon H, Kim SW, Kim H, Kim YT, Kim JH, Kim JW and Kim S: MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res. 14:2690–2695. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Wang G, Mao W, Zheng S and Ye J: Epidermal growth factor receptor-regulated miR-125a-5p-a metastatic inhibitor of lung cancer. FEBS J. 276:5571–5578. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y and Mori M: MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with Trastuzumab. Clin Cancer Res. 17:2725–2733. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Li W, Xie L, He X, Li J, Tu K, Wei L, Wu J, Guo Y, Ma X, Zhang P, et al: Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma. Int J Cancer. 123:1616–1622. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Bi Q, Tang S, Xia L, Du R, Fan R, Gao L, Jin J, Liang S, Chen Z, Xu G, et al: Ectopic expression of miR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF. PLoS One. 7:e401692012. View Article : Google Scholar : PubMed/NCBI

43 

Potenza N, Papa U, Mosca N, Zerbini F, Nobile V and Rosso A: Human microRNA hsa-miR-125a-5p interferes with expression of hepatitis B virus surface antigen. Nucleic Acid Res. 39:5157–5163. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Coppola N, Potenza N, Pisaturo M, Mosca N, Tonziello G, Signoriello G, Messina V, Sagnelli C, Russo A and Sagnelli E: Liver microRNA hsa-miR-125a-5p in HBV chronic infection: Correlation with HBV replication and disease progression. PLoS One. 8:e653362013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Oura K, Fujita K, Morishita A, Iwama H, Nakahara M, Tadokoro T, Sakamoto T, Nomura T, Yoneyama H, Mimura S, Mimura S, et al: Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma. Oncol Lett 18: 882-890, 2019.
APA
Oura, K., Fujita, K., Morishita, A., Iwama, H., Nakahara, M., Tadokoro, T. ... Masaki, T. (2019). Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma. Oncology Letters, 18, 882-890. https://doi.org/10.3892/ol.2019.10385
MLA
Oura, K., Fujita, K., Morishita, A., Iwama, H., Nakahara, M., Tadokoro, T., Sakamoto, T., Nomura, T., Yoneyama, H., Mimura, S., Tani, J., Kobara, H., Okano, K., Suzuki, Y., Masaki, T."Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma". Oncology Letters 18.1 (2019): 882-890.
Chicago
Oura, K., Fujita, K., Morishita, A., Iwama, H., Nakahara, M., Tadokoro, T., Sakamoto, T., Nomura, T., Yoneyama, H., Mimura, S., Tani, J., Kobara, H., Okano, K., Suzuki, Y., Masaki, T."Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma". Oncology Letters 18, no. 1 (2019): 882-890. https://doi.org/10.3892/ol.2019.10385
Copy and paste a formatted citation
x
Spandidos Publications style
Oura K, Fujita K, Morishita A, Iwama H, Nakahara M, Tadokoro T, Sakamoto T, Nomura T, Yoneyama H, Mimura S, Mimura S, et al: Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma. Oncol Lett 18: 882-890, 2019.
APA
Oura, K., Fujita, K., Morishita, A., Iwama, H., Nakahara, M., Tadokoro, T. ... Masaki, T. (2019). Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma. Oncology Letters, 18, 882-890. https://doi.org/10.3892/ol.2019.10385
MLA
Oura, K., Fujita, K., Morishita, A., Iwama, H., Nakahara, M., Tadokoro, T., Sakamoto, T., Nomura, T., Yoneyama, H., Mimura, S., Tani, J., Kobara, H., Okano, K., Suzuki, Y., Masaki, T."Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma". Oncology Letters 18.1 (2019): 882-890.
Chicago
Oura, K., Fujita, K., Morishita, A., Iwama, H., Nakahara, M., Tadokoro, T., Sakamoto, T., Nomura, T., Yoneyama, H., Mimura, S., Tani, J., Kobara, H., Okano, K., Suzuki, Y., Masaki, T."Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma". Oncology Letters 18, no. 1 (2019): 882-890. https://doi.org/10.3892/ol.2019.10385
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