Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

HTLV‑1‑associated genes as potential biomarkers for endometrial cancer

  • Authors:
    • Gang Du
    • Wenqian Zhang
    • Zhen Zhang
    • Meizhai Zeng
    • Yuxia Wang
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510000, P.R. China, Department of Reproductive Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510000, P.R. China, Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangzhou, Guangdong 510080, P.R. China, Department of Bioinformatics, Guangzhou GenCoding Lab, Guangzhou, Guangdong 510670, P.R. China
    Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 699-705
    |
    Published online on: May 21, 2019
       https://doi.org/10.3892/ol.2019.10389
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Endometrial carcinoma (EC) is a malignant neoplasm of the endometrial epithelium, which may be diagnosed by pathological investigations. The aim of the current study was to identify new markers for the diagnosis of EC using machine learning. The association between human T cell lymphotropic virus type 1 (HTLV‑1) infection and endometrial cancer risk have not been widely reported. It remains ambiguous whether HTLV‑1 infection is associated with several types of cancer. The present study investigated the association between HTLV‑1 infection‑associated genes and EC risk. RNA sequencing uterine cancer expression data were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) were identified between normal and matched tumor samples. A total of 41 genes were selected by an overlap between HTLV‑1 infection pathway‑associated genes and the DEGs. Two‑way hierarchical clustering analysis (HCA) and a support vector machine (SVM) classifier were constructed using the 41 genes. The accuracy of the candidate genes in risk‑stratifying the samples was 100%. The accuracy of the proposed SVM model was 100%. In addition, the classification power of the SVM model was validated using a merged dataset (TCGA and the Genotype‑Tissue Expression project). This predictive feature achieved reliable outcomes with risk‑stratifying samples of almost 99% in two‑way HCA, and an accuracy yield of 98% of the SVM classifier. In conclusion, the 41 genes identified in the current study may be implicated in the development of EC and may be of prognostic value for the disease. The results obtained the current study suggest that HTLV‑1 may be potentially associated with EC and highlight potential disease mechanisms.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Cohn D, Crispens MA, et al: Uterine neoplasms, version 1.2018, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 16:170–199. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Mahecha AM and Wang H: The influence of vascular endothelial growth factor-A and matrix metalloproteinase-2 and −9 in angiogenesis, metastasis, and prognosis of endometrial cancer. Onco Targets Ther. 10:4617–4624. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Siegel RL, Miller KD and Jemal A: Cancer sstatistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Malik TY, Chishti U, Aziz AB and Sheikh I: Comparison of risk factors and survival of type 1 and type II endometrial cancers. Pak J Med Sci. 32:886–890. 2016.PubMed/NCBI

5 

Mittica G, Ghisoni E, Giannone G, Aglietta M, Genta S and Valabrega G: Checkpoint inhibitors in endometrial cancer: Preclinical rationale and clinical activity. Oncotarget. 8:90532–90544. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Fakhar S, Saeed G, Khan AH and Alam AY: Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding. Ann Saudi Med. 28:188–191. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Yoshida M: Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis. Oncogene. 24:5931–5937. 2005. View Article : Google Scholar : PubMed/NCBI

8 

IARC working group on the evaluation of carcinogenic risks to humans, . Human immunodeficiency viruses and human T-cell lymphotropic viruses. Lyon, France, 1–18 June 1996. IARC Monogr Eval Carcinog Risks Hum. 67:1–424. 1996.PubMed/NCBI

9 

Human T-cell lymphotropic viruses, . IARC Monogr Eval Carcinog Risks Hum. 67:261–390. 1996.PubMed/NCBI

10 

de Thé G and Kazanji M: An HTLV–I/II vaccine: From animal models to clinical trials? J Acquir Immune Defic Syndr Hum Retrovirol. 13 (Suppl 1):S191–S198. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Martín-Dávila P, Fortún J, López-Vélez R, Norman F, Montes de Oca M, Zamarrón P, González MI, Moreno A, Pumarola T, Garrido G, et al: Transmission of tropical and geographically restricted infections during solid-organ transplantation. Clin Microbiol Rev. 21:60–96. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Hollsberg P and Hafler DA: Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection. New Eng J Med. 328:1173–1182. 1993. View Article : Google Scholar : PubMed/NCBI

13 

Proietti FA, Carneiro-Proietti AB, Catalan-Soares BC and Murphy EL: Global epidemiology of HTLV–I infection and associated diseases. Oncogene. 24:6058–6068. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Kannian P and Green PL: Human T lymphotropic virus type 1 (HTLV-1): Molecular biology and oncogenesis. Viruses. 2:2037–2077. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Yamanaka S, Nakayama K, Tamai H, Sakamaki M and Inokuchi K: Adult T-cell leukemia-lymphoma complicated by Takotsubo cardiomyopathy and HTLV-1-associated myelopathy after treatment with the anti-CCR4 antibody mogamulizumab. Rinsho Ketsueki. 58:309–314. 2017.(In Japanese). PubMed/NCBI

16 

Tanaka T, Hirata T, Parrott G, Higashiarakawa M, Kinjo T, Kinjo T, Hokama A and Fujita J: Relationship among strongyloides stercoralis infection, human T-cell lymphotropic virus type 1 infection, and cancer: A 24-year cohort inpatient study in Okinawa, Japan. Am J Trop Med Hyg. 94:365–370. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Howard C: The Interplay between HTLV-1 Viral Factors, Tax and HBZ, During T-cell Transformation. The Ohio State University. 2016.

18 

Vicario M, Mattiolo A, Montini B, Piano MA, Cavallari I, Amadori A, Chieco-Bianchi L and Calabrò ML: A preclinical model for the atll lymphoma subtype with insights into the role of microenvironment in HTLV-1-mediated lymphomagenesis. Front Microbiol. 9:12152018. View Article : Google Scholar : PubMed/NCBI

19 

Chen JL, Limnander A and Rothman PB: Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene. Blood. 111:1677–1685. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Guo G, Qiu X, Wang S, Chen Y, Rothman PB, Wang Z, Chen Y, Wang G and Chen JL: Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells. Oncogene. 29:3845–3853. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Yang J, Wang J, Chen K, Guo G, Xi R, Rothman PB, Whitten D, Zhang L, Huang S and Chen JL: eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer Res. 73:4898–4908. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Love M, Anders S and Huber W: Differential analysis of count data - the DESeq2 package. Genome Biol. 15:5502014. View Article : Google Scholar : PubMed/NCBI

23 

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, et al: Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol. 5:R802004. View Article : Google Scholar : PubMed/NCBI

24 

Therneau TM: Survival analysis [R package survival version 2.41–3]. Technometrics. 46:111–112. 2015.

25 

Wang L, Cao C, Ma Q, Zeng Q, Wang H, Cheng Z, Zhu G, Qi J, Ma H, Nian H and Wang Y: RNA-seq analyses of multiple meristems of soybean: Novel and alternative transcripts, evolutionary and functional implications. BMC Plant Biol. 14:1692014. View Article : Google Scholar : PubMed/NCBI

26 

Arisawa K, Soda M, Akahoshi M, Fujiwara S, Uemura H, Hiyoshi M, Takeda H, Kashino W and Suyama A: Human T-cell lymphotropic virus type-1 infection and risk of cancer: 15.4 year longitudinal study among atomic bomb survivors in Nagasaki, Japan. Cancer Sci. 97:535–539. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Kozuru M, Uike N, Muta K, Goto T, Suehiro Y and Nagano M: High occurrence of primary malignant neoplasms in patients with adult T-cell leukemia/lymphoma, their siblings, and their mothers. Cancer. 78:1119–1124. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Beltran BE, Quiñones P, Morales D, Revilla JC, Alva JC and Castillo JJ: Diffuse large B-cell lymphoma in human T-lymphotropic virus type 1 carriers. Leuk Res Treatment. 2012:2623632012.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Du G, Zhang W, Zhang Z, Zeng M and Wang Y: HTLV‑1‑associated genes as potential biomarkers for endometrial cancer. Oncol Lett 18: 699-705, 2019.
APA
Du, G., Zhang, W., Zhang, Z., Zeng, M., & Wang, Y. (2019). HTLV‑1‑associated genes as potential biomarkers for endometrial cancer. Oncology Letters, 18, 699-705. https://doi.org/10.3892/ol.2019.10389
MLA
Du, G., Zhang, W., Zhang, Z., Zeng, M., Wang, Y."HTLV‑1‑associated genes as potential biomarkers for endometrial cancer". Oncology Letters 18.1 (2019): 699-705.
Chicago
Du, G., Zhang, W., Zhang, Z., Zeng, M., Wang, Y."HTLV‑1‑associated genes as potential biomarkers for endometrial cancer". Oncology Letters 18, no. 1 (2019): 699-705. https://doi.org/10.3892/ol.2019.10389
Copy and paste a formatted citation
x
Spandidos Publications style
Du G, Zhang W, Zhang Z, Zeng M and Wang Y: HTLV‑1‑associated genes as potential biomarkers for endometrial cancer. Oncol Lett 18: 699-705, 2019.
APA
Du, G., Zhang, W., Zhang, Z., Zeng, M., & Wang, Y. (2019). HTLV‑1‑associated genes as potential biomarkers for endometrial cancer. Oncology Letters, 18, 699-705. https://doi.org/10.3892/ol.2019.10389
MLA
Du, G., Zhang, W., Zhang, Z., Zeng, M., Wang, Y."HTLV‑1‑associated genes as potential biomarkers for endometrial cancer". Oncology Letters 18.1 (2019): 699-705.
Chicago
Du, G., Zhang, W., Zhang, Z., Zeng, M., Wang, Y."HTLV‑1‑associated genes as potential biomarkers for endometrial cancer". Oncology Letters 18, no. 1 (2019): 699-705. https://doi.org/10.3892/ol.2019.10389
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team