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Article Open Access

Association of miR‑100 expression with clinicopathological features and prognosis of patients with lung cancer

  • Authors:
    • Xiaolong Ma
    • Jiaqi Zhou
    • Hongyan Mo
    • Ying Ying
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, The First Hospital of Jiaxing, Jiaxing, Zhejiang 314000, P.R. China, Department of Cardiothoracic Surgery, The First Hospital of Jiaxing, Jiaxing, Zhejiang 314000, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1318-1322
    |
    Published online on: May 22, 2019
       https://doi.org/10.3892/ol.2019.10393
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Abstract

The expression of microRNA (miR)‑100 in non‑small cell lung cancer (NSCLC) and its association with clinicopathological features and poor prognosis were investigated. A total of 283 patients with NSCLC were enrolled in The First Hospital of Jiaxing from February 2013 to April 2015. Total RNA was extracted from cancer tissues and corresponding adjacent normal tissues. The expression of miR‑100 was detected by RT‑qPCR. Association between the expression level of miR‑100 with clinicopathological features and prognosis of NSCLC were analyzed. The expression level of miR‑100 in NSCLC tissues was lower than that in the normal tissues (P<0.05). According to the median expression level of miR‑100 in cancer tissue, patients were divided into the high expression and low expression groups. Cross‑tabulation analysis showed that the expression level of miR‑100 was significantly associated with patients' age, TNM stage, metastasis and histological type (P<0.05), but not with sex (P>0.05). The proportion of patients with low miR‑100 expression was higher in patients who died than in those who survived (P<0.05). Univariate prognostic analysis showed that miR‑100 expression, age, TNM staging, and metastasis may be risk factors for poor prognosis in patients with NSCLC. Cox multivariate regression analysis showed that the downregulated miR‑100 expression, advanced TNM stage, and metastasis were independent risk factors for poor prognosis of NSCLC. The relatively low expression level of miR‑100 in NSCLC is associated with poor prognosis of patients. Therefore, miR‑100 shows potential as a prognostic marker for NSCLC.
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1 

Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, Lee W, Yuan J, Wong P, Ho TS, et al: Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 348:124–128. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Lortet-Tieulent J, Soerjomataram I, Ferlay J, Rutherford M, Weiderpass E and Bray F: International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer. 84:13–22. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Markou A, Sourvinou I, Vorkas PA, Yousef GM and Lianidou E: Clinical evaluation of microRNA expression profiling in non small cell lung cancer. Lung Cancer. 81:388–396. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Yang JJ, Chen HJ, Yan HH, Zhang XC, Zhou Q, Su J, Wang Z, Xu CR, Huang YS, Wang BC, et al: Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer. Lung Cancer. 79:33–39. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, et al: Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 373:123–135. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Herbst RS, Baas P, Kim DW, Felip E, Pérez-Gracia JL, Han JY, Molina J, Kim JH, Arvis CD, Ahn MJ, et al: Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 387:1540–1550. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Shaw AT, Kim DW, Nakagawa K, Seto T, Crinó L, Ahn MJ, De Pas T, Besse B, Solomon BJ, Blackhall F, et al: Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 368:2385–2394. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Molina R, Filella X, Augé JM, Fuentes R, Bover I, Rifa J, Moreno V, Canals E, Viñolas N, Marquez A, et al: Tumor markers (CEA, CA 125, CYFRA 21-1, SCC and NSE) in patients with non-small cell lung cancer as an aid in histological diagnosis and prognosis. Comparison with the main clinical and pathological prognostic factors. Tumour Biol. 24:209–218. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Okamura K, Takayama K, Izumi M, Harada T, Furuyama K and Nakanishi Y: Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer. Lung Cancer. 80:45–49. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, et al LifeLines Cohort Study; CARDIoGRAM Consortium; DIAGRAM Consortium; ICBP Consortium; MAGIC Consortium, : Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 45:145–154. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Chen P, Zhao X and Ma L: Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in hepatocellular carcinoma. Mol Cell Biochem. 383:49–58. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Xu C, Zeng Q, Xu W, Jiao L, Chen Y, Zhang Z, Wu C, Jin T, Pan A, Wei R, et al: miRNA-100 inhibits human bladder urothelial carcinogenesis by directly targeting mTOR. Mol Cancer Ther. 12:207–219. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Ashworth A, Rodrigues G, Boldt G and Palma D: Is there an oligometastatic state in non-small cell lung cancer? A systematic review of the literature. Lung Cancer. 82:197–203. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Fu HL, Wu DP, Wang XF, Wang JG, Jiao F, Song LL, Xie H, Wen XY, Shan HS, Du YX, et al: Altered miRNA expression is associated with differentiation, invasion, and metastasis of esophageal squamous cell carcinoma (ESCC) in patients from Huaian, China. Cell Biochem Biophys. 67:657–668. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Yang XD, Xu XH, Zhang SY, Wu Y, Xing CG, Ru G, Xu HT and Cao JP: Role of miR-100 in the radioresistance of colorectal cancer cells. Am J Cancer Res. 5:545–559. 2015.PubMed/NCBI

17 

Qin C, Huang RY and Wang ZX: Potential role of miR-100 in cancer diagnosis, prognosis, and therapy. Tumour Biol. 36:1403–1409. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Gong Y, He T, Yang L, Yang G, Chen Y and Zhang X: The role of miR-100 in regulating apoptosis of breast cancer cells. Sci Rep. 5:116502015. View Article : Google Scholar : PubMed/NCBI

19 

Huang JS, Egger ME, Grizzle WE and McNally LR: MicroRNA-100 regulates IGF1-receptor expression in metastatic pancreatic cancer cells. Biotech Histochem. 88:397–402. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Leite KR, Morais DR, Reis ST, Viana N, Moura C, Florez MG, Silva IA, Dip N and Srougi M: MicroRNA 100: a context dependent miRNA in prostate cancer. Clinics (São Paulo). 68:797–802. 2013. View Article : Google Scholar

21 

Chen J, Zheng B, Wang C, Chen Y, Du C, Zhao G, Zhou Y and Shi Y: Prognostic role of microRNA-100 in various carcinomas: evidence from six studies. Tumour Biol. 35:3067–3071. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Cao YH, Zhang HH, Xu HF, Duan YJ, Li Q and Huang B: Prognostic role of microRNA-100 in patients with bladder cancer. Genet Mol Res. 14:15948–15954. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma X, Zhou J, Mo H and Ying Y: Association of miR‑100 expression with clinicopathological features and prognosis of patients with lung cancer. Oncol Lett 18: 1318-1322, 2019.
APA
Ma, X., Zhou, J., Mo, H., & Ying, Y. (2019). Association of miR‑100 expression with clinicopathological features and prognosis of patients with lung cancer. Oncology Letters, 18, 1318-1322. https://doi.org/10.3892/ol.2019.10393
MLA
Ma, X., Zhou, J., Mo, H., Ying, Y."Association of miR‑100 expression with clinicopathological features and prognosis of patients with lung cancer". Oncology Letters 18.2 (2019): 1318-1322.
Chicago
Ma, X., Zhou, J., Mo, H., Ying, Y."Association of miR‑100 expression with clinicopathological features and prognosis of patients with lung cancer". Oncology Letters 18, no. 2 (2019): 1318-1322. https://doi.org/10.3892/ol.2019.10393
Copy and paste a formatted citation
x
Spandidos Publications style
Ma X, Zhou J, Mo H and Ying Y: Association of miR‑100 expression with clinicopathological features and prognosis of patients with lung cancer. Oncol Lett 18: 1318-1322, 2019.
APA
Ma, X., Zhou, J., Mo, H., & Ying, Y. (2019). Association of miR‑100 expression with clinicopathological features and prognosis of patients with lung cancer. Oncology Letters, 18, 1318-1322. https://doi.org/10.3892/ol.2019.10393
MLA
Ma, X., Zhou, J., Mo, H., Ying, Y."Association of miR‑100 expression with clinicopathological features and prognosis of patients with lung cancer". Oncology Letters 18.2 (2019): 1318-1322.
Chicago
Ma, X., Zhou, J., Mo, H., Ying, Y."Association of miR‑100 expression with clinicopathological features and prognosis of patients with lung cancer". Oncology Letters 18, no. 2 (2019): 1318-1322. https://doi.org/10.3892/ol.2019.10393
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