Diagnostic value and clinical significance of ultrasound combined with CT in cystic renal cell carcinoma

Sun,Minghui; Wang,Chao; Jiang,Fei; Fang,Xiuhong; Guo,Bingcheng

doi:10.3892/ol.2019.10422

Diagnostic value and clinical significance of ultrasound combined with CT in cystic renal cell carcinoma

Authors:
- Minghui Sun
- Chao Wang
- Fei Jiang
- Xiuhong Fang
- Bingcheng Guo
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Affiliations: Department of Medical Ultrasonics, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong 264000, P.R. China, CT Room, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Radiology Department, People's Hospital of Dongying, Dongying, Shandong 257091, P.R. China, Department of Ultrasound, Jining No. 1 People's Hospital, Jining, Shandong 272100, P.R. China
Published online on: May 30, 2019 https://doi.org/10.3892/ol.2019.10422
Pages: 1395-1401
Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This study investigated the value and clinical significance of ultrasound combined with CT in the diagnosis of cystic renal cell carcinoma. A total of 85 patients with cystic renal cell carcinoma, who were admitted to the Oncology Department of Yantai Yuhuangding Hospital Affiliated to Qingdao University from December 2015 to April 2017, were selected as the study group, and 70 patients with benign renal cyst, who were examined in Yantai Yuhuangding Hospital Affiliated to Qingdao University, were selected as the benign group. The patients in the two groups were examined by ultrasound and CT. The diagnostic value of ultrasound, CT, and ultrasound combined with CT in cystic renal cell carcinoma was analyzed. The sensitivity of ultrasound combined with CT was significantly higher than that of CT and ultrasound (P<0.05). The specificity and diagnostic coincidence rate of ultrasound combined with CT were significantly higher than those of CT (P<0.05). For unicapsular kidney cancer, there was no significant difference among ultrasound, CT and ultrasound combined with CT in the diagnosis of septum and wall nodule (P>0.05). For polycystic kidney cancer, there was no significant difference among ultrasound, CT and ultrasound combined with CT in the diagnosis of the presence or absence of septum (P>0.05). Ultrasound was significantly better than CT in cyst wall confounding (P<0.05). Ultrasound combined with CT was significantly better than ultrasound in calcification and blood supply of tumors (P<0.05). In conclusion, the accuracy of ultrasound combined with CT is higher than that of ultrasound or that of CT in the diagnosis of cystic renal cell carcinoma, which can be beneficial in accurately carrying out clinical diagnosis, reduce the incidence of missed diagnosis and misdiagnosis caused by a single diagnosis and treatment. Ultrasound combined with CT is good for clinical screening and can guide clinical symptomatic treatment, which is worthy of generalizing in clinic.

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1	Gummadi S, Eisenbrey JR and Lyshchik A: Contrast-enhanced ultrasonography in interventional oncology. Abdom Radiol (NY). 43:3166–3175. 2018. View Article : Google Scholar : PubMed/NCBI
2	Zhou D, Quan Z and Wang J: Current status of malignant mesothelioma with liver involvement in China: A brief report and review of the literature. Intractable Rare Dis Res. 7:112–119. 2018. View Article : Google Scholar : PubMed/NCBI
3	Liu B, Chen J, Jiang H, Wang S, Shen BH, Jin BY and Xie LP: Diagnosis and treatment of cystic renal cell carcinoma: A report of 14 cases. Zhonghua Yi Xue Za Zhi. 91:2861–2862. 2011.(In Chinese). PubMed/NCBI
4	Sirohi D, Smith SC, Agarwal N and Maughan BL: Unclassified renal cell carcinoma: Diagnostic difficulties and treatment modalities. Res Rep Urol. 10:205–217. 2018.PubMed/NCBI
5	Bindayi A, Mcdonald ML, Beksac AT, Rivera-Sanfeliz G, Shabaik A, Hughes F, Aganovic L, Hansel DE and Derweesh IH: Can multiphase CT scan distinguish between papillary renal cell carcinoma type 1 and type 2? Turk J Urol. 44:316–322. 2018.PubMed/NCBI
6	Kim SH, Kwon WA, Joung JY, Seo HK, Lee KH and Chung J: Clear cell papillary renal cell carcinoma: A case report and review of the literature. World J Nephrol. 7:155–160. 2018. View Article : Google Scholar : PubMed/NCBI
7	Mahajan A, Deshpande SS and Thakur MH: Diffusion magnetic resonance imaging: a molecular imaging tool caught between hope, hype and the real world of ‘personalized oncology’. World J Radiol. 9:253–268. 2017. View Article : Google Scholar : PubMed/NCBI
8	Deng B, Lundqvist M, Fang Q and Carp SA: Impact of errors in experimental parameters on reconstructed breast images using diffuse optical tomography. Biomed Opt Express. 9:1130–1150. 2018. View Article : Google Scholar : PubMed/NCBI
9	Deán-Ben XL, Gottschalk S, Mc Larney B, Shoham S and Razansky D: Advanced optoacoustic methods for multiscale imaging of in vivo dynamics. Chem Soc Rev. 46:2158–2198. 2017. View Article : Google Scholar : PubMed/NCBI
10	Baldari D, Capece S, Mainenti PP, Tucci AG, Klain M, Cozzolino I, Salvatore M and Maurea S: Comparison between computed tomography multislice and high-field magnetic resonance in the diagnostic evaluation of patients with renal masses. Quant Imaging Med Surg. 5:691–699. 2015.PubMed/NCBI
11	Sevcenco S, Spick C, Helbich TH, Heinz G, Shariat SF, Klingler HC, Rauchenwald M and Baltzer PA: Malignancy rates and diagnostic performance of the Bosniak classification for the diagnosis of cystic renal lesions in computed tomography - a systematic review and meta-analysis. Eur Radiol. 27:2239–2247. 2017. View Article : Google Scholar : PubMed/NCBI
12	Aboagye EO and Kraeber-Bodéré F: Highlights lecture EANM 2016: ‘Embracing molecular imaging and multi-modal imaging: a smart move for nuclear medicine towards personalized medicine’. Eur J Nucl Med Mol Imaging. 44:1559–1574. 2017. View Article : Google Scholar : PubMed/NCBI
13	Chung SD, Liu SP and Lin HC: A population-based study on the association between urinary calculi and kidney cancer. Can Urol Assoc J. 7:E716–E721. 2013. View Article : Google Scholar : PubMed/NCBI
14	Lévy P, Hélénon O, Merran S, Paraf F, Méjean A, Cornud F and Moreau JF: Cystic tumors of the kidney in adults: Radio-histopathologic correlations. J Radiol. 80:121–133. 1999.(In French). PubMed/NCBI
15	Sadiq M, Ahmad I, Shuja J, Ahmad Z, Ahmed R and Ahmad K: Astroblastoma in a young female patient: A case report and literature review of clinicopathological, radiological and prognostic characteristics and current treatment strategies. Brain Tumor Res Treat. 5:120–126. 2017. View Article : Google Scholar : PubMed/NCBI
16	Gao XH, Hua YQ, Ding JG, Zhan JX, Song T, Yin YL, Qian WQ and Song JD: Value of spiral CT in diagnosis of cystic renal cell carcinoma. Zhonghua Zhong Liu Za Zhi. 28:130–133. 2006.(In Chinese). PubMed/NCBI
17	Bah I, Fahiminiya S, Bégin LR, Hamel N, D'Agostino MD, Tanguay S and Foulkes WD: Atypical tuberous sclerosis complex presenting as familial renal cell carcinoma with leiomyomatous stroma. J Pathol Clin Res. 4:167–174. 2018. View Article : Google Scholar : PubMed/NCBI
18	Weibl P, Hora M, Kollarik B, Kalusova K, Pitra T, Remzi M, Hübner W, Balzer P and Klatte T: A practical guide and decision-making protocol for the management of complex renal cystic masses. Arab J Urol. 15:115–122. 2017. View Article : Google Scholar : PubMed/NCBI
19	Xu HX: Contrast-enhanced ultrasound: The evolving applications. World J Radiol. 1:15–24. 2009. View Article : Google Scholar : PubMed/NCBI
20	Israel GM, Hindman N and Bosniak MA: Evaluation of cystic renal masses: comparison of CT and MR imaging by using the Bosniak classification system. Radiology. 231:365–371. 2004. View Article : Google Scholar : PubMed/NCBI
21	Park BK, Kim B, Kim SH, Ko K, Lee HM and Choi HY: Assessment of cystic renal masses based on Bosniak classification: Comparison of CT and contrast-enhanced US. Eur J Radiol. 61:310–314. 2007. View Article : Google Scholar : PubMed/NCBI
22	Quaia E, Bertolotto M, Cioffi V, Rossi A, Baratella E, Pizzolato R and Cov MA: Comparison of contrast-enhanced sonography with unenhanced sonography and contrast-enhanced CT in the diagnosis of malignancy in complex cystic renal masses. AJR Am J Roentgenol. 191:1239–1249. 2008. View Article : Google Scholar : PubMed/NCBI
23	Ragel M, Nedumaran A and Makowska-Webb J: Prospective comparison of use of contrast-enhanced ultrasound and contrast-enhanced computed tomography in the Bosniak classification of complex renal cysts. Ultrasound. 24:6–16. 2016. View Article : Google Scholar : PubMed/NCBI
24	Lal A, Naranje P and Pavunesan SK: What's new in urologic ultrasound? Indian J Urol. 31:176–184. 2015. View Article : Google Scholar : PubMed/NCBI
25	Bukhari S, Amodu A, Akinyemi M and Wallach S: Persistent hematuria caused by renal cell carcinoma after aortic valve replacement and warfarin therapy. Proc Bayl Univ Med Cent. 30:327–329. 2017. View Article : Google Scholar : PubMed/NCBI
26	Rafailidis V, Fang C, Yusuf GT, Huang DY and Sidhu PS: Contrast-enhanced ultrasound (CEUS) of the abdominal vasculature. Abdom Radiol (NY). 43:934–947. 2018. View Article : Google Scholar : PubMed/NCBI
27	Seyam RM, Alkhudair WK, Kattan SA, Alotaibi MF, Alzahrani HM and Altaweel WM: The risks of renal angiomyolipoma: Reviewing the evidence. J Kidney Cancer VHL. 4:13–25. 2017. View Article : Google Scholar : PubMed/NCBI
28	Katabathina VS, Garg D, Prasad SR and Vikram R: Cystic renal neoplasms and renal neoplasms associated with cystic renal diseases in adults: cross-sectional imaging findings. J Comput Assist Tomogr. 36:659–668. 2012. View Article : Google Scholar : PubMed/NCBI
29	Xu L, Liang S, Yan N, Zhang L, Gu H, Fei X, Xu Y and Zhang F: Metastatic gastric cancer from breast carcinoma: A report of 78 cases. Oncol Lett. 14:4069–4077. 2017. View Article : Google Scholar : PubMed/NCBI