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Cervical carcinoma high‑expressed long non‑coding RNA 1 may promote growth of colon adenocarcinoma through interleukin‑17A

  • Authors:
    • Jue Wang
    • Hui Li
    • Cuiying Zhang
    • Liying Xue
    • Zhihui Cai
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010017, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1491-1496
    |
    Published online on: May 31, 2019
       https://doi.org/10.3892/ol.2019.10425
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Abstract

Cervical carcinoma high‑expressed long non‑coding RNA 1 (CCHE1) has been demonstrated to promote several different types of cancer; however, the involvement of CCHE1 in other types of cancer remains unknown. In the present study, the expression levels of CCHE1 and interleukin (IL)‑17A were increased in the plasma of patients with metastatic and non‑metastatic colon adenocarcinoma (MC and NMC, respectively) compared with the healthy controls. There was no significant difference in the plasma expression levels of CCHE1 and IL‑17A in patients with MC compared with patients with NMC. The plasma expression levels of CCHE1 and IL‑17A were positively associated with the primary tumor diameter. A significant correlation as demonstrated between the serum levels of CCHE1 and IL‑17A in patients with colon adenocarcinoma, but not in the healthy controls. CCHE1 and IL‑17A overexpression promoted colon adenocarcinoma cell proliferation. Transfection of small interfering RNA against IL‑17A partially reversed the effects of CCHE1 overexpression on cancer cell proliferation. Upregulation of IL‑17A was observed after CCHE1 overexpression, while IL‑17A overexpression did not significantly change the expression level of CCHE1. Therefore, CCHE1 may promote growth of colon adenocarcinoma through interactions with IL‑17A.
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1 

Siegel R, Desantis C and Jemal A: Colorectal cancer statistics, 2014. CA Cancer J Clin. 64:104–117. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Maddams J, Utley M and Moller H: Projections of cancer prevalence in the United Kingdom, 2010–2040. Br J Cancer. 107:1195–1202. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Wang L, Wilson SE, Stewart DB and Hollenbeak CS: Marital status and colon cancer outcomes in us Surveillance, epidemiology and end results registries: Does marriage affect cancer survival by gender and stage? Cancer Epidemiol. 35:417–422. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Chiu BC, Ji BT, Dai Q, Gridley G, McLaughlin JK, Gao YT, Fraumeni JF Jr and Chow WH: Dietary factors and risk of colon cancer in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 12:201–208. 2003.PubMed/NCBI

5 

Hou L, Ji BT, Blair A, Dai Q, Gao YT and Chow WH: Commuting physical activity and risk of colon cancer in Shanghai, China. Am J Epidemiol. 160:860–867. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Benson AB III, Bekaii-Saab T, Chan E, Chen YJ, Choti MA, Cooper HS, Engstrom PF, Enzinger PC, Fakih MG, Fenton MJ, et al: Metastatic colon cancer, version 3.2013: Featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 11:141–152. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Terzic J, Grivennikov S, Karin E and Karin M: Inflammation and colon cancer. Gastroenterology. 138:2101–2114.e5. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Rei M, Goncalves-Sousa N, Lanca T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ and Silva-Santos B: Murine CD27(−) Vgamma6(+) gammadelta T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci USA. 111:E3562–E3570. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Ma S, Cheng Q, Cai Y, Gong H, Wu Y, Yu X, Shi L, Wu D, Dong C and Liu H: IL-17A produced by gammadelta T cells promotes tumor growth in hepatocellular carcinoma. Cancer Res. 74:1969–1982. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Srivastava A, Nikamo P, Lohcharoenkal W, Li D, Meisgen F, Xu Landén N, Ståhle M, Pivarcsi A and Sonkoly E: MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis. J Allergy Clin Immunol. 139:550–561. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Yanagisawa N, Maeda K, Ajisawa A, Imamura A, Suganuma A, Ando M, Takayama N and Okuno Y: Reduced immune response to influenza A (H1N1) 2009 monovalent vaccine in HIV-infected Japanese subjects. Vaccine. 29:5694–5698. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Liao Y, Cheng S, Xiang J and Luo C: lncRNA CCHE1 increased proliferation, metastasis and invasion of non-small lung cancer cells and predicted poor survival in non-small lung cancer patients. Eur Rev Med Pharmacol Sci. 22:1686–1692. 2018.PubMed/NCBI

13 

Xu G, Zhang Y, Li N, Zhang JB and Xu R: LncRNA CCHE1 in the proliferation and apoptosis of gastric cancer cells. Eur Rev Med Pharmacol Sci. 22:2631–2637. 2018.PubMed/NCBI

14 

Yang M, Zhai X, Xia B, Wang Y and Lou G: Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregulating PCNA. Tumour Biol. 36:7615–7622. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Peng W and Fan H: Long noncoding RNA CCHE1 indicates a poor prognosis of hepatocellular carcinoma and promotes carcinogenesis via activation of the ERK/MAPK pathway. Biomed Pharmacother. 83:450–455. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Gaballah HH, Gaber RA, Elrashidy MA, Elshahat DA, Hablus MA and Ebeid AM: Expression of long non-coding RNA CCHE1 in colorectal carcinoma: Correlations with clinicopathological features and ERK/COX-2 pathway. Mol Biol Rep. 46:657–667. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Mace AG, Pai RK, Stocchi L and Kalady MF: American joint committee on cancer and college of american pathologists regression grade: A new prognostic factor in rectal cancer. Dis Colon Rectum. 58:32–44. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Xue Y, Ma G, Gu D, Zhu L, Hua Q, Du M, Chu H, Tong N, Chen J, Zhang Z and Wang M: Genome-wide analysis of long noncoding RNA signature in human colorectal cancer. Gene. 556:227–234. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Shi J, Li X, Zhang F, Zhang C, Guan Q, Cao X, Zhu W, Zhang X, Cheng Y, Ou K, et al: Circulating lncRNAs associated with occurrence of colorectal cancer progression. Am J Cancer Res. 5:2258–2265. 2015.PubMed/NCBI

21 

Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D and Yu H: IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med. 206:1457–1464. 2009. View Article : Google Scholar : PubMed/NCBI

22 

He D, Li H, Yusuf N, Elmets CA, Li J, Mountz JD and Xu H: IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. J Immunol. 184:2281–2288. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Yang B, Kang H, Fung A, Zhao H, Wang T and Ma D: The role of interleukin 17 in tumour proliferation, angiogenesis, and metastasis. Mediators Inflamm. 2014:6237592014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Li H, Zhang C, Xue L and Cai Z: Cervical carcinoma high‑expressed long non‑coding RNA 1 may promote growth of colon adenocarcinoma through interleukin‑17A. Oncol Lett 18: 1491-1496, 2019.
APA
Wang, J., Li, H., Zhang, C., Xue, L., & Cai, Z. (2019). Cervical carcinoma high‑expressed long non‑coding RNA 1 may promote growth of colon adenocarcinoma through interleukin‑17A. Oncology Letters, 18, 1491-1496. https://doi.org/10.3892/ol.2019.10425
MLA
Wang, J., Li, H., Zhang, C., Xue, L., Cai, Z."Cervical carcinoma high‑expressed long non‑coding RNA 1 may promote growth of colon adenocarcinoma through interleukin‑17A". Oncology Letters 18.2 (2019): 1491-1496.
Chicago
Wang, J., Li, H., Zhang, C., Xue, L., Cai, Z."Cervical carcinoma high‑expressed long non‑coding RNA 1 may promote growth of colon adenocarcinoma through interleukin‑17A". Oncology Letters 18, no. 2 (2019): 1491-1496. https://doi.org/10.3892/ol.2019.10425
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Li H, Zhang C, Xue L and Cai Z: Cervical carcinoma high‑expressed long non‑coding RNA 1 may promote growth of colon adenocarcinoma through interleukin‑17A. Oncol Lett 18: 1491-1496, 2019.
APA
Wang, J., Li, H., Zhang, C., Xue, L., & Cai, Z. (2019). Cervical carcinoma high‑expressed long non‑coding RNA 1 may promote growth of colon adenocarcinoma through interleukin‑17A. Oncology Letters, 18, 1491-1496. https://doi.org/10.3892/ol.2019.10425
MLA
Wang, J., Li, H., Zhang, C., Xue, L., Cai, Z."Cervical carcinoma high‑expressed long non‑coding RNA 1 may promote growth of colon adenocarcinoma through interleukin‑17A". Oncology Letters 18.2 (2019): 1491-1496.
Chicago
Wang, J., Li, H., Zhang, C., Xue, L., Cai, Z."Cervical carcinoma high‑expressed long non‑coding RNA 1 may promote growth of colon adenocarcinoma through interleukin‑17A". Oncology Letters 18, no. 2 (2019): 1491-1496. https://doi.org/10.3892/ol.2019.10425
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