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Expression of the immune checkpoint receptor TIGIT in seminoma

  • Authors:
    • Andrea Hinsch
    • Niclas C. Blessin
    • Ronald Simon
    • Martina Kluth
    • Kristine Fischer
    • Claudia Hube‑Magg
    • Wenchao Li
    • Georgia Makrypidi‑Fraune
    • Björn Wellge
    • Tim Mandelkow
    • Nicolaus F. Debatin
    • Doris Höflmayer
    • Maximilian Lennartz
    • Guido Sauter
    • Jakob R. Izbicki
    • Sarah Minner
    • Franziska Büscheck
    • Ria Uhlig
    • David Dum
    • Till Krech
    • Andreas M. Luebke
    • Corinna Wittmer
    • Frank Jacobsen
    • Eike Burandt
    • Stefan Steurer
    • Waldemar Wilczak
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, University Medical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany, ONCOdianova GmbH, D‑20354 Hamburg, Germany, Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany
    Copyright: © Hinsch et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1497-1502
    |
    Published online on: May 31, 2019
       https://doi.org/10.3892/ol.2019.10428
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Abstract

A characteristic feature of testicular seminoma is the abundance of immune cells in the tumor microenvironment, raising the possibility that immune checkpoint inhibitors may serve as a therapeutic option in these types of tumors. T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory immune checkpoint receptor in analogy to PD‑1, and drugs targeting TIGIT are currently being investigated in clinical trials. Little is known about the expression of these proteins in testicular seminomas. Therefore the present study performed immunohistochemical analysis to determine the relative abundance of TIGIT and PD‑1 in relation to the total CD3+ immune cell infiltration in a tissue microarray (TMA) constructed from 78 seminoma patients. The fraction of TIGIT+ and PD‑1+ lymphocytes was highly variable in individual cancers and ranged from 2.3 to 69.4% (mean: 32.2±14.7%) for TIGIT and from 0.8 to 56.5% (mean: 21.6±13.2%) for PD‑1. The same high degree of variability was also identified for the ratio of PD‑1 to TIGIT positive cells, which varied from a dominance of TIGIT (PD‑1: TIGIT ratio=0.02) in 74% of patients, to a predominance of PD‑1 (PD‑1: TIGIT ratio=12.5) in 23% of patients. In summary, the immune checkpoint receptors TIGIT and PD‑1 are abundantly expressed in human seminomas. Once available, anti‑TIGIT antibodies, possibly in combination with anti‑PD‑1 drugs, may be a reasonable therapeutic strategy for this type of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Hinsch A, Blessin NC, Simon R, Kluth M, Fischer K, Hube‑Magg C, Li W, Makrypidi‑Fraune G, Wellge B, Mandelkow T, Mandelkow T, et al: Expression of the immune checkpoint receptor TIGIT in seminoma. Oncol Lett 18: 1497-1502, 2019.
APA
Hinsch, A., Blessin, N.C., Simon, R., Kluth, M., Fischer, K., Hube‑Magg, C. ... Wilczak, W. (2019). Expression of the immune checkpoint receptor TIGIT in seminoma. Oncology Letters, 18, 1497-1502. https://doi.org/10.3892/ol.2019.10428
MLA
Hinsch, A., Blessin, N. C., Simon, R., Kluth, M., Fischer, K., Hube‑Magg, C., Li, W., Makrypidi‑Fraune, G., Wellge, B., Mandelkow, T., Debatin, N. F., Höflmayer, D., Lennartz, M., Sauter, G., Izbicki, J. R., Minner, S., Büscheck, F., Uhlig, R., Dum, D., Krech, T., Luebke, A. M., Wittmer, C., Jacobsen, F., Burandt, E., Steurer, S., Wilczak, W."Expression of the immune checkpoint receptor TIGIT in seminoma". Oncology Letters 18.2 (2019): 1497-1502.
Chicago
Hinsch, A., Blessin, N. C., Simon, R., Kluth, M., Fischer, K., Hube‑Magg, C., Li, W., Makrypidi‑Fraune, G., Wellge, B., Mandelkow, T., Debatin, N. F., Höflmayer, D., Lennartz, M., Sauter, G., Izbicki, J. R., Minner, S., Büscheck, F., Uhlig, R., Dum, D., Krech, T., Luebke, A. M., Wittmer, C., Jacobsen, F., Burandt, E., Steurer, S., Wilczak, W."Expression of the immune checkpoint receptor TIGIT in seminoma". Oncology Letters 18, no. 2 (2019): 1497-1502. https://doi.org/10.3892/ol.2019.10428
Copy and paste a formatted citation
x
Spandidos Publications style
Hinsch A, Blessin NC, Simon R, Kluth M, Fischer K, Hube‑Magg C, Li W, Makrypidi‑Fraune G, Wellge B, Mandelkow T, Mandelkow T, et al: Expression of the immune checkpoint receptor TIGIT in seminoma. Oncol Lett 18: 1497-1502, 2019.
APA
Hinsch, A., Blessin, N.C., Simon, R., Kluth, M., Fischer, K., Hube‑Magg, C. ... Wilczak, W. (2019). Expression of the immune checkpoint receptor TIGIT in seminoma. Oncology Letters, 18, 1497-1502. https://doi.org/10.3892/ol.2019.10428
MLA
Hinsch, A., Blessin, N. C., Simon, R., Kluth, M., Fischer, K., Hube‑Magg, C., Li, W., Makrypidi‑Fraune, G., Wellge, B., Mandelkow, T., Debatin, N. F., Höflmayer, D., Lennartz, M., Sauter, G., Izbicki, J. R., Minner, S., Büscheck, F., Uhlig, R., Dum, D., Krech, T., Luebke, A. M., Wittmer, C., Jacobsen, F., Burandt, E., Steurer, S., Wilczak, W."Expression of the immune checkpoint receptor TIGIT in seminoma". Oncology Letters 18.2 (2019): 1497-1502.
Chicago
Hinsch, A., Blessin, N. C., Simon, R., Kluth, M., Fischer, K., Hube‑Magg, C., Li, W., Makrypidi‑Fraune, G., Wellge, B., Mandelkow, T., Debatin, N. F., Höflmayer, D., Lennartz, M., Sauter, G., Izbicki, J. R., Minner, S., Büscheck, F., Uhlig, R., Dum, D., Krech, T., Luebke, A. M., Wittmer, C., Jacobsen, F., Burandt, E., Steurer, S., Wilczak, W."Expression of the immune checkpoint receptor TIGIT in seminoma". Oncology Letters 18, no. 2 (2019): 1497-1502. https://doi.org/10.3892/ol.2019.10428
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