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Article Open Access

Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions

  • Authors:
    • Qin Shi
    • Ling Xu
    • Rong Yang
    • Yaping Meng
    • Lihua Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201800, P.R. China, Department of Pathology, Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201800, P.R. China, Department of Obstetrics and Gynecology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1351-1355
    |
    Published online on: June 3, 2019
       https://doi.org/10.3892/ol.2019.10430
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Abstract

Expression of Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions were investigated. A total of 64 paraffin‑embedded specimens of uterus tissue from young female patients who were admitted to Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences from January 2015 to December 2017 were selected. According to pathological examination, the specimens were divided into chronic cervicitis group (control group, 10 cases), low‑grade squamous intraepithelial lesion (LSIL) group (12 cases), high‑grade squamous intraepithelial lesion (HSIL) group (20 cases) and squamous carcinoma of the cervix (SCC) group (22 cases). Expression of Ki‑67 and P16 protein was detected by immunohistochemistry and the diagnostic values were analyzed. Positive rates of Ki‑67 and P16 expression in HSIL and SCC groups were significantly higher than those in LSIL and control groups (P<0.05), but there was no significant difference between LSIL and control groups (P>0.05). Spearman's analysis showed that the expression levels of Ki‑67 and P16 were positively correlated with the degree of cervical lesions (rs=0.725; rs=0.829), and their expression levels were also positively correlated (rs=0.772). Sensitivity and specificity analysis showed that the Ki‑67 diagnosis has higher sensitivity (95.2%), but the specificity is poor (86.7%). Diagnosis using P16 has high specificity (94.6%), but the sensitivity is poor (85.4%). When the two were combined for diagnosis, sensitivity (94.8%) and specificity (93.2%) were both at a high level. The combined detection of Ki‑67 and P16 protein has a high application prospect as an auxiliary diagnosis of SCC.
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Copy and paste a formatted citation
Spandidos Publications style
Shi Q, Xu L, Yang R, Meng Y and Qiu L: Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions. Oncol Lett 18: 1351-1355, 2019.
APA
Shi, Q., Xu, L., Yang, R., Meng, Y., & Qiu, L. (2019). Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions. Oncology Letters, 18, 1351-1355. https://doi.org/10.3892/ol.2019.10430
MLA
Shi, Q., Xu, L., Yang, R., Meng, Y., Qiu, L."Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions". Oncology Letters 18.2 (2019): 1351-1355.
Chicago
Shi, Q., Xu, L., Yang, R., Meng, Y., Qiu, L."Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions". Oncology Letters 18, no. 2 (2019): 1351-1355. https://doi.org/10.3892/ol.2019.10430
Copy and paste a formatted citation
x
Spandidos Publications style
Shi Q, Xu L, Yang R, Meng Y and Qiu L: Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions. Oncol Lett 18: 1351-1355, 2019.
APA
Shi, Q., Xu, L., Yang, R., Meng, Y., & Qiu, L. (2019). Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions. Oncology Letters, 18, 1351-1355. https://doi.org/10.3892/ol.2019.10430
MLA
Shi, Q., Xu, L., Yang, R., Meng, Y., Qiu, L."Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions". Oncology Letters 18.2 (2019): 1351-1355.
Chicago
Shi, Q., Xu, L., Yang, R., Meng, Y., Qiu, L."Ki‑67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions". Oncology Letters 18, no. 2 (2019): 1351-1355. https://doi.org/10.3892/ol.2019.10430
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