Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2019 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2019 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ‑specific metastases in patients with advanced prostatic adenocarcinoma

  • Authors:
    • Yuyou Deng
    • Ran Bi
    • Zhenhua Zhu
    • Shengxian Li
    • Bo Xu
    • Wakeel Ahmad Rather
    • Chunxi Wang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130012, P.R. China, Department of Orthopedic Trauma, The First Hospital of Jilin University, Changchun, Jilin 130012, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1057-1070
    |
    Published online on: June 7, 2019
       https://doi.org/10.3892/ol.2019.10461
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Prostate cancer (PCa) survival markedly decreases with the occurrence of distant metastasis, and treatment decisions can be influenced by metastasis site, and affect patient survival outcomes. The aim of the present study was to evaluate the potential prognostic value of metastasis to specific sites and the prognostic value of prostatectomy in patients with only bone metastasis, and to determine potential risk factors for bone metastasis in prostatic adenocarcinoma using large scale clinical data. The Surveillance, Epidemiology and End Results (SEER) database (2010‑2013) was queried via the SEER*Stat (version 8.3.4) program. A total of 210,730 prostatic adenocarcinoma patients were identified from the SEER database between January 2010 and December 2013. Univariate and multivariate Cox regression analysis and Kaplan‑Meier curves were used for survival comparisons with corresponding 95% confidence intervals. Patients with PCa with only liver metastatic lesions had worse overall and cancer‑specific survival rates compared with those patients with only bone or lung metastasis. Multivariate Cox regression analysis revealed that age <50 years, married status, T1 and T3 tumor stage according to Tumor‑Node‑Metastasis (TNM) staging system from the 7th AJCC cancer staging manual, and prostatectomy were associated with better overall survival and cancer‑specific survival in patients with only bone metastasis. Binary logistic regression analysis revealed that unmarried status, African descent and undifferentiated histological grade were risk factors for PCa bone metastasis. Prostatic adenocarcinoma patients with only liver metastasis had worse prognostic outcomes compared with patients with other distant organ metastases. Prostatectomy improved the 3‑year survival rate in stage IV PCa patients and stage IV PCa patients with only bone metastasis. These findings were based on large‑scale clinical data and can provide novel perspectives for the treatment of patients with advanced prostate adenocarcinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Yamada Y, Naruse K, Nakamura K, Taki T, Tobiume M, Zennami K, Nishikawa G, Itoh Y, Muramatsu Y, Nanaura H, et al: Investigation of risk factors for prostate cancer patients with bone metastasis based on clinical data. Exp Ther Med. 1:635–639. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Heidenreich A, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, Mottet N, Schmid HP, van der Kwast T, Wiegel T, et al: EAU guidelines on prostate cancer. Part 1: Screening, diagnosis, and treatment of clinically localised disease. Eur Urol. 59:61–71. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Yang L, Drake BF and Colditz GA: Obesity and other cancers. J Clin Oncol. 34:4231–4237. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Humphrey PA: Histopathology of prostate cancer. Cold Spring Harb Perspect Med. 7:a0304112017. View Article : Google Scholar : PubMed/NCBI

6 

Bill-Axelson A, Holmberg L, Filén F, Ruutu M, Garmo H, Busch C, Nordling S, Häggman M, Andersson SO, Bratell S, et al: Radical prostatectomy versus watchful waiting in localized prostate cancer: The Scandinavian prostate cancer group-4 randomized trial. J Natl Cancer Inst. 100:1144–1154. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Veeratterapillay R, Goonewardene SS, Barclay J, Persad R and Bach C: Radical prostatectomy for locally advanced and metastatic prostate cancer. Ann R Coll Surg Engl. 99:259–264. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Culp SH, Schellhammer PF and Williams MB: Might men diagnosed with metastatic prostate cancer benefit from definitive treatment of the primary tumor? A SEER-based study. Eur Urol. 65:1058–1066. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Stephen B, David R, Carolyn C and April G: AJCC cancer staging manual seventh edition. Am Joint Committee Cancer. 2010, https://cancerstaging.org/references-tools/deskreferences/Pages/default.aspxAugust 29–2017

10 

Adamo M, Dickie L and Ruhl J: SEER program coding and staging manual 2016. National Cancer Institute; Bethesda, MD 20850-9765, U.S.: Department of Health and Human Services National Institutes of Health National Cancer Institute, . 2016, https://seer.cancer.gov/tools/codingmanuals/historical.htmlAugust 29–2017

11 

Fisher LD and Lin DY: Time-dependent covariates in the Cox proportional-hazards regression model. Annu Rev Public Health. 20:145–157. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Freedland SJ, Partin AW, Humphreys EB, Mangold LA and Walsh PC: Radical prostatectomy for clinical stage T3a disease. Cancer. 109:1273–1278. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Heng DY, Wells JC, Rini BI, Beuselinck B, Lee JL, Knox JJ, Bjarnason GA, Pal SK, Kollmannsberger CK, Yuasa T, et al: Cytoreductive nephrectomy in patients with synchronous metastases from renal cell carcinoma: Results from the international metastatic renal cell carcinoma database consortium. Eur Urol. 66:704–710. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Keutgen XM, Nilubol N, Glanville J, Sadowski SM, Liewehr DJ, Venzon DJ, Steinberg SM and Kebebew E: Resection of primary tumor site is associated with prolonged survival in metastatic nonfunctioning pancreatic neuroendocrine tumors. Surgery. 159:311–318. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Hüttner FJ, Schneider L, Tarantino I, Warschkow R, Schmied BM, Hackert T, Diener MK, Büchler MW and Ulrich A: Palliative resection of the primary tumor in 442 metastasized neuroendocrine tumors of the pancreas: A population-based, propensity score-matched survival analysis. Langenbecks Arch Surg. 400:715–723. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Abdel-Rahman O: Role of liver-directed local tumor therapy in the management of hepatocellular carcinoma with extrahepatic metastases: A SEER database analysis. Expert Rev Gastroenterol Hepatol. 11:183–189. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Abou-Alfa GK and Venook AP: The impact of new data in the treatment of advanced hepatocellular carcinoma. Curr Oncol Rep. 10:199–205. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Oweira H, Petrausch U, Helbling D, Schmidt J, Mannhart M, Mehrabi A, Schöb O, Giryes A, Decker M and Abdel-Rahman O: Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A surveillance epidemiology and end results database analysis. World J Gastroenterol. 23:1872–1880. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Shien T, Nakamura K, Shibata T, Kinoshita T, Aogi K, Fujisawa T, Masuda N, Inoue K, Fukuda H and Iwata H: A randomized controlled trial comparing primary tumour resection plus systemic therapy with systemic therapy alone in metastatic breast cancer (PRIM-BC): Japan Clinical Oncology Group Study JCOG1017. Jpn J Clin Oncol. 42:970–973. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Ruiterkamp J, Voogd AC, Tjan-Heijnen VC, Bosscha K, van der Linden YM, Rutgers EJ, Boven E, van der Sangen MJ and Ernst MF; Dutch Breast Cancer Trialists' Group (BOOG), : SUBMIT: Systemic therapy with or without up front surgery of the primary tumor in breast cancer patients with distant metastases at initial presentation. BMC Surg. 12:52012. View Article : Google Scholar : PubMed/NCBI

21 

Fields RC, Jeffe DB, Trinkaus K, Zhang Q, Arthur C, Aft R, Dietz JR, Eberlein TJ, Gillanders WE and Margenthaler JA: Surgical resection of the primary tumor is associated with increased long-term survival in patients with stage IV breast cancer after controlling for site of metastasis. Ann Surg Oncol. 14:3345–3351. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Comen E, Norton L and Massagué J: Clinical implications of cancer self-seeding. Nat Rev Clin Oncol. 8:369–377. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Norton L: Cancer stem cells, self-seeding, and decremented exponential growth: Theoretical and clinical implications. Breast Dis. 29:27–36. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Resel Folkersma L, San José Manso L, Galante Romo I, Moreno Sierra J and Olivier Gómez C: Prognostic significance of circulating tumor cell count in patients with metastatic hormone-sensitive prostate cancer. Urology. 80:1328–1332. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Cooperberg MR, Broering JM and Carroll PR: Risk assessment for prostate cancer metastasis and mortality at the time of diagnosis. J Natl Cancer Inst. 101:878–887. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Cook MM, Rosenberg PS, McCarty FA, Wu M, King J, Eheman C and Anderson WF: Racial disparities in prostate cancer incidence rates by census division in the United States, 1999–2008. Prostate. 75:758–763. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Brawley OW, Jani AB and Master V: Prostate cancer and race. Curr Probl Cancer. 31:211–225. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Guo X, Zhang C, Guo Q, Xu Y, Feng G, Li L, Han X, Lu F, Ma Y, Wang X and Wang G: The homogeneous and heterogeneous risk factors for the morbidity and prognosis of bone metastasis in patients with prostate cancer. Cancer Manag Res. 10:1639–1646. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Deng Y, Bi R, Zhu Z, Li S, Xu B, Rather WA and Wang C: A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ‑specific metastases in patients with advanced prostatic adenocarcinoma. Oncol Lett 18: 1057-1070, 2019.
APA
Deng, Y., Bi, R., Zhu, Z., Li, S., Xu, B., Rather, W.A., & Wang, C. (2019). A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ‑specific metastases in patients with advanced prostatic adenocarcinoma. Oncology Letters, 18, 1057-1070. https://doi.org/10.3892/ol.2019.10461
MLA
Deng, Y., Bi, R., Zhu, Z., Li, S., Xu, B., Rather, W. A., Wang, C."A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ‑specific metastases in patients with advanced prostatic adenocarcinoma". Oncology Letters 18.2 (2019): 1057-1070.
Chicago
Deng, Y., Bi, R., Zhu, Z., Li, S., Xu, B., Rather, W. A., Wang, C."A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ‑specific metastases in patients with advanced prostatic adenocarcinoma". Oncology Letters 18, no. 2 (2019): 1057-1070. https://doi.org/10.3892/ol.2019.10461
Copy and paste a formatted citation
x
Spandidos Publications style
Deng Y, Bi R, Zhu Z, Li S, Xu B, Rather WA and Wang C: A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ‑specific metastases in patients with advanced prostatic adenocarcinoma. Oncol Lett 18: 1057-1070, 2019.
APA
Deng, Y., Bi, R., Zhu, Z., Li, S., Xu, B., Rather, W.A., & Wang, C. (2019). A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ‑specific metastases in patients with advanced prostatic adenocarcinoma. Oncology Letters, 18, 1057-1070. https://doi.org/10.3892/ol.2019.10461
MLA
Deng, Y., Bi, R., Zhu, Z., Li, S., Xu, B., Rather, W. A., Wang, C."A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ‑specific metastases in patients with advanced prostatic adenocarcinoma". Oncology Letters 18.2 (2019): 1057-1070.
Chicago
Deng, Y., Bi, R., Zhu, Z., Li, S., Xu, B., Rather, W. A., Wang, C."A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ‑specific metastases in patients with advanced prostatic adenocarcinoma". Oncology Letters 18, no. 2 (2019): 1057-1070. https://doi.org/10.3892/ol.2019.10461
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team