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Achieving adequate lymph node dissection in treating esophageal squamous cell carcinomas by radical lymphadenectomy: Beyond the scope of numbers of harvested lymph nodes

  • Authors:
    • Zheng Lin
    • Weilin Chen
    • Yuanmei Chen
    • Xiane Peng
    • Siyou Yan
    • Fei He
    • Rong Fu
    • Yixian Jiang
    • Zhijian Hu
  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian 350108, P.R. China, Department of Radiation Oncology, Affiliated Zhangzhou Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, P.R. China, Department of Thoracic Surgery, Fujian Provincial Cancer Hospital, Fuzhou, Fujian 350014, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1617-1630
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    Published online on: June 12, 2019
       https://doi.org/10.3892/ol.2019.10465
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Abstract

Previous studies have recommended harvesting a large number of lymph nodes (LNs) to improve the survival of patients with esophageal squamous cell carcinoma (ESCC). These studies or clinical guidelines focus on the total harvested LNs during lymphadenectomy; however, the extent of LN dissection (LND) required in patients with ESCCs remains controversial. The present study proposed a novel individualized adequate LND (ALND) strategy to compliment current guidelines to improve individualized therapeutic efficacy. For N0 cases, ALND was defined as an LN harvest of >55% of the LNs from nodal zones adjacent to the tumor location; and for N+ cases, ALND was defined as 8, 8, 8, 8 or 16 LNs dissected from the involved cervical, upper, middle, lower and celiac zones, respectively. Retrospective analysis of the ESCC cohort revealed that the ALND was associated with improved patient survival [hazard ratio (HR)=0.45 and 95% CI=0.30‑0.66)]. Stratified analyses revealed that the protective role of ALND was prominent, with the exception of higher pN+ staged (pN2‑3) cases (HR=0.52, 95% CI=0.23‑1.18). Furthermore, ALND was associated with improved survival in local diseases (T1‑3/N0‑1; HR=0.50, 95% CI=0.30‑0.84) and locally advanced diseases (T4/Nany or T1‑3/N2‑3; HR=0.32, 95% CI=0.15‑0.68). These findings suggested that the proposed ALND strategy may effectively improve the survival of patients with ESCC.
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View References

1 

Vashist YK, Loos J, Dedow J, Tachezy M, Uzunoglu G, Kutup A, Yekebas EF and Izbicki JR: Glasgow prognostic score is a predictor of perioperative and long-term outcome in patients with only surgically treated esophageal cancer. Ann Surg Oncol. 18:1130–1138. 2011. View Article : Google Scholar : PubMed/NCBI

2 

O'Sullivan B, Brierley J and International Union against Cancer: UICC manual of clinical oncology. John Wiley and Sons Ltd.; Chichester, West Sussex, UK; Hoboken, NJ: 2015, View Article : Google Scholar

3 

Edge SB and American Joint Committee on Cancer, . AJCC cancer staging manual. Springer; New York: 2010

4 

Hu Y, Hu C, Zhang H, Ping Y and Chen LQ: How does the number of resected lymph nodes influence TNM staging and prognosis for esophageal carcinoma? Ann Surg Oncol. 17:784–790. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Peyre CG, Hagen JA, DeMeester SR, Altorki NK, Ancona E, Griffin SM, Hölscher A, Lerut T, Law S, Rice TW, et al: The number of lymph nodes removed predicts survival in esophageal cancer: An international study on the impact of extent of surgical resection. Ann Surg. 248:549–556. 2008.PubMed/NCBI

6 

Rizk NP, Ishwaran H, Rice TW, Chen LQ, Schipper PH, Kesler KA, Law S, Lerut TE, Reed CE, Salo JA, et al: Optimum lymphadenectomy for esophageal cancer. Ann Surg. 251:46–50. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Groth SS, Virnig BA, Whitson BA, DeFor TE, Li ZZ, Tuttle TM and Maddaus MA: Determination of the minimum number of lymph nodes to examine to maximize survival in patients with esophageal carcinoma: Data from the surveillance epidemiology and end results database. J Thorac Cardiovasc Surg. 139:612–620. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Chen YJ, Schultheiss TE, Wong JY and Kernstine KH: Impact of the number of resected and involved lymph nodes on esophageal cancer survival. J Surg Oncol. 100:127–132. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Schwarz RE and Smith DD: Clinical impact of lymphadenectomy extent in resectable esophageal cancer. J Gastrointest Surg. 11:1384–1394. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Rizk N: Surgery for esophageal cancer: Goals of resection and optimizing outcomes. Thorac Surg Clin. 23:491–498. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Phillips AW, Lagarde SM, Navidi M, Disep B and Griffin SM: Impact of extent of lymphadenectomy on survival, post neoadjuvant chemotherapy and transthoracic esophagectomy. Ann Surg. 265:750–756. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Baba Y, Watanabe M, Shigaki H, Iwagami S, Ishimoto T, Iwatsuki M and Baba H: Negative lymph-node count is associated with survival in patients with resected esophageal squamous cell carcinoma. Surgery. 153:234–241. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Bogoevski D, Onken F, Koenig A, Kaifi JT, Schurr P, Sauter G, Izbicki JR and Yekebas EF: Is it time for a new TNM classification in esophageal carcinoma? Ann Surg. 247:633–641. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Lin Z, Chen W, Chen Y, Peng X, Zhu K, Lin Y, Lin Q and Hu Z: A new classification of lymph node metastases according to the lymph node stations for predicting prognosis in surgical patients with esophageal squamous cell carcinoma. Oncotarget. 7:76261–76273. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Rice TW, Blackstone EH and Rusch VW: 7th edition of the AJCC cancer staging manual: Esophagus and esophagogastric junction. Ann Surg Oncol. 17:1721–1724. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Niwa Y, Koike M, Hattori M, Iwata N, Takami H, Hayashi M, Tanaka C, Kobayashi D, Kanda M, Yamada S, et al: The prognostic relevance of subcarinal lymph node dissection in esophageal squamous cell carcinoma. Ann Surg Oncol. 23:611–618. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Kato H and Nakajima M: Treatments for esophageal cancer: A review. Gen Thorac Cardiovasc Surg. 61:330–335. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Hsieh FY and Lavori PW: Sample-size calculations for the Cox proportional hazards regression model with nonbinary covariates. Control Clin Trials. 21:552–560. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Camp RL, Dolled-Filhart M and Rimm DL: X-tile: A new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 10:7252–7259. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Schoenfeld D: Partial residuals for the proportional hazards regression model. Biometrika. 69:239–241. 1982. View Article : Google Scholar

21 

Nafteux P, Lerut A, Moons J, Hölscher AH, Bollschweiler E, van Berge Henegouwen MI, Lagarde SM, van Lanschot JJ, Messager M, Mariette C, et al: International multicenter study on the impact of extracapsular lymph node involvement in primary surgery adenocarcinoma of the esophagus on overall survival and staging systems. Ann Surg. 262:809–816. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Lagergren J, Mattsson F, Zylstra J, Chang F, Gossage J, Mason R, Lagergren P and Davies A: Extent of lymphadenectomy and prognosis after esophageal cancer surgery. JAMA Surg. 151:32–39. 2016. View Article : Google Scholar : PubMed/NCBI

23 

van der Schaaf M, Johar A, Wijnhoven B, Lagergren P and Lagergren J: Extent of lymph node removal during esophageal cancer surgery and survival. J Natl Cancer Inst. 107(pii): djv0432015.PubMed/NCBI

24 

Talsma AK, Damhuis RA, Steyerberg EW, Rosman C, van Lanschot JJ and Wijnhoven BP: Determinants of improved survival after oesophagectomy for cancer. Br J Surg. 102:668–675. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Hulscher JB, van Sandick JW, de Boer AG, Wijnhoven BP, Tijssen JG, Fockens P, Stalmeier PF, ten Kate FJ, van Dekken H, Obertop H, et al: Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus. N Engl J Med. 347:1662–1669. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Chu KM, Law SY, Fok M and Wong J: A prospective randomized comparison of transhiatal and transthoracic resection for lower-third esophageal carcinoma. Am J Surg. 174:320–324. 1997. View Article : Google Scholar : PubMed/NCBI

27 

Nishihira T, Hirayama K and Mori S: A prospective randomized trial of extended cervical and superior mediastinal lymphadenectomy for carcinoma of the thoracic esophagus. Am J Surg. 175:47–51. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Hsu PK, Wang BY, Chou TY, Huang CS, Wu YC and Hsu WH: The total number of resected lymph node is not a prognostic factor for recurrence in esophageal squamous cell carcinoma patients undergone transthoracic esophagectomy. J Surg Oncol. 103:416–420. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Chao YK, Liu HP, Hsieh MJ, Wu YC, Liu YH, Yeh CH, Chang HK and Tseng CK: Impact of the number of lymph nodes sampled on outcome in ypT0N0 esophageal squamous cell carcinoma patients. J Surg Oncol. 106:436–440. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Miyata H, Yamasaki M, Makino T, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M and Doki Y: Therapeutic value of lymph node dissection for esophageal squamous cell carcinoma after neoadjuvant chemotherapy. J Surg Oncol. 112:60–65. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Rizk N, Venkatraman E, Park B, Flores R, Bains MS and Rusch V; American Joint Committee on Cancer staging system, : The prognostic importance of the number of involved lymph nodes in esophageal cancer: Implications for revisions of the American Joint Committee on Cancer staging system. J Thorac Cardiovasc Surg. 132:1374–1381. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Barbour AP, Rizk NP, Gonen M, Tang L, Bains MS, Rusch VW, Coit DG and Brennan MF: Lymphadenectomy for adenocarcinoma of the gastroesophageal junction (GEJ): Impact of adequate staging on outcome. Ann Surg Oncol. 14:306–316. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Lerut T, Nafteux P, Moons J, Coosemans W, Decker G, De Leyn P, Van Raemdonck D and Ectors N: Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections: Impact on staging, disease-free survival, and outcome: A plea for adaptation of TNM classification in upper-half esophageal carcinoma. Ann Surg. 240:962–974. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Chen J, Liu S, Pan J, Zheng X, Zhu K, Zhu J, Xiao J and Ying M: The pattern and prevalence of lymphatic spread in thoracic oesophageal squamous cell carcinoma. Eur J Cardiothorac Surg. 36:480–486. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Tachimori Y, Ozawa S, Numasaki H, Matsubara H, Shinoda M, Toh Y, Udagawa H, Fujishiro M, Oyama T, Uno T, et al: Efficacy of lymph node dissection by node zones according to tumor location for esophageal squamous cell carcinoma. Esophagus. 13:1–7. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Brotons ML, Bolca C, Fréchette E and Deslauriers J: Anatomy and physiology of the thoracic lymphatic system. Thorac Surg Clin. 22:139–153. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Motoyama S, Maruyama K, Sato Y, Usami S, Nakatsu T, Saito H, Minamiya Y and Ogawa J: Status of involved lymph nodes and direction of metastatic lymphatic flow between submucosal and t2-4 thoracic squamous cell esophageal cancers. World J Surg. 33:512–517. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Izbicki JR, Hosch SB, Pichlmeier U, Rehders A, Busch C, Niendorf A, Passlick B, Broelsch CE and Pantel K: Prognostic value of immunohistochemically identifiable tumor cells in lymph nodes of patients with completely resected esophageal cancer. N Engl J Med. 337:1188–1194. 1997. View Article : Google Scholar : PubMed/NCBI

39 

Imamura Y, Hayashi N, Sato N, Kinoshita K, Kurashige J, Saito S, Hirashima K, Karashima R, Hiyoshi Y, Nagai Y, et al: Extensive lymphatic spread of cancer cells in patients with thoracic esophageal squamous cell carcinoma: Detection of CEA-mRNA in the three-field lymph nodes. J Surg Oncol. 102:509–515. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Wang LS, Chow KC, Chi KH, Liu CC, Li WY, Chiu JH and Huang MH: Prognosis of esophageal squamous cell carcinoma: Analysis of clinicopathological and biological factors. Am J Gastroenterol. 94:1933–1940. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Zheng YZ, Zhao W, Hu Y, Ding-Lin XX, Wen J, Yang H, Liu QW, Luo KJ, Huang QY, Chen JY and Fu JH: Aggressive surgical resection does not improve survival in operable esophageal squamous cell carcinoma with N2-3 status. World J Gastroenterol. 21:8644–8652. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Stein HJ, Feith M, Bruecher BL, Naehrig J, Sarbia M and Siewert JR: Early esophageal cancer: Pattern of lymphatic spread and prognostic factors for long-term survival after surgical resection. Ann Surg. 242:566–575. 2005.PubMed/NCBI

43 

Smyth EC, Fassan M, Cunningham D, Allum WH, Okines AF, Lampis A, Hahne JC, Rugge M, Peckitt C, Nankivell M, et al: Effect of pathologic tumor response and nodal status on survival in the medical research council adjuvant gastric infusional chemotherapy trial. J Clin Oncol. 34:2721–2727. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Su D, Zhou X, Chen Q, Jiang Y, Yang X, Zheng W, Tao K, Wu J, Yan Z, Liu L, et al: Prognostic nomogram for thoracic esophageal squamous cell carcinoma after radical esophagectomy. PLoS One. 10:e01244372015. View Article : Google Scholar : PubMed/NCBI

45 

Haverkamp L, Seesing MF, Ruurda JP, Boone J and V Hillegersberg R: Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer. Dis Esophagus. 30:1–7. 2017.

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Copy and paste a formatted citation
Spandidos Publications style
Lin Z, Chen W, Chen Y, Peng X, Yan S, He F, Fu R, Jiang Y and Hu Z: Achieving adequate lymph node dissection in treating esophageal squamous cell carcinomas by radical lymphadenectomy: Beyond the scope of numbers of harvested lymph nodes. Oncol Lett 18: 1617-1630, 2019.
APA
Lin, Z., Chen, W., Chen, Y., Peng, X., Yan, S., He, F. ... Hu, Z. (2019). Achieving adequate lymph node dissection in treating esophageal squamous cell carcinomas by radical lymphadenectomy: Beyond the scope of numbers of harvested lymph nodes. Oncology Letters, 18, 1617-1630. https://doi.org/10.3892/ol.2019.10465
MLA
Lin, Z., Chen, W., Chen, Y., Peng, X., Yan, S., He, F., Fu, R., Jiang, Y., Hu, Z."Achieving adequate lymph node dissection in treating esophageal squamous cell carcinomas by radical lymphadenectomy: Beyond the scope of numbers of harvested lymph nodes". Oncology Letters 18.2 (2019): 1617-1630.
Chicago
Lin, Z., Chen, W., Chen, Y., Peng, X., Yan, S., He, F., Fu, R., Jiang, Y., Hu, Z."Achieving adequate lymph node dissection in treating esophageal squamous cell carcinomas by radical lymphadenectomy: Beyond the scope of numbers of harvested lymph nodes". Oncology Letters 18, no. 2 (2019): 1617-1630. https://doi.org/10.3892/ol.2019.10465
Copy and paste a formatted citation
x
Spandidos Publications style
Lin Z, Chen W, Chen Y, Peng X, Yan S, He F, Fu R, Jiang Y and Hu Z: Achieving adequate lymph node dissection in treating esophageal squamous cell carcinomas by radical lymphadenectomy: Beyond the scope of numbers of harvested lymph nodes. Oncol Lett 18: 1617-1630, 2019.
APA
Lin, Z., Chen, W., Chen, Y., Peng, X., Yan, S., He, F. ... Hu, Z. (2019). Achieving adequate lymph node dissection in treating esophageal squamous cell carcinomas by radical lymphadenectomy: Beyond the scope of numbers of harvested lymph nodes. Oncology Letters, 18, 1617-1630. https://doi.org/10.3892/ol.2019.10465
MLA
Lin, Z., Chen, W., Chen, Y., Peng, X., Yan, S., He, F., Fu, R., Jiang, Y., Hu, Z."Achieving adequate lymph node dissection in treating esophageal squamous cell carcinomas by radical lymphadenectomy: Beyond the scope of numbers of harvested lymph nodes". Oncology Letters 18.2 (2019): 1617-1630.
Chicago
Lin, Z., Chen, W., Chen, Y., Peng, X., Yan, S., He, F., Fu, R., Jiang, Y., Hu, Z."Achieving adequate lymph node dissection in treating esophageal squamous cell carcinomas by radical lymphadenectomy: Beyond the scope of numbers of harvested lymph nodes". Oncology Letters 18, no. 2 (2019): 1617-1630. https://doi.org/10.3892/ol.2019.10465
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