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Article

MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway

  • Authors:
    • Tao Song
    • Xinghua Hou
    • Bing Lin
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Weifang Maternity and Child Care Hospital, Weifang, Shandong 261042, P.R. China, Department of Women Health Care, Weifang Maternity and Child Care Hospital, Weifang, Shandong 261042, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1786-1792
    |
    Published online on: June 12, 2019
       https://doi.org/10.3892/ol.2019.10470
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Abstract

Cervical cancer (CC) remains a highly prevalent cancer and cause of mortality amongst women worldwide. miR‑758 has been demonstrated to be associated with tumorigenesis by controlling the expression of oncogenic or tumor suppressor genes. However, the function and mechanisms of miR‑758 in CC have not been well illustrated. The present study aimed to dissect the effect of miR‑758 on the proliferation, migration and invasion of CC cells and determine the potential underlying molecular mechanism of these effects. qPCR results revealed that the expression of miR‑758 was significantly decreased in CC tissues and cell lines compared with that in normal tissues and normal cells. Results of CCK‑8, colony formation and Transwell assays revealed that miR‑758 overexpression markedly decreased cell viability, proliferation, invasion and migration. However, miR‑758 inhibitors significantly increased viability, proliferation, invasion and migration. In the mechanism study, we demonstrated that high mobility group box 3 (HMGB3) was a direct target of miR‑758, and HMGB3 overexpression rescued the viability, proliferation, invasion and migration of HeLa cells reduced by an miR‑758 mimic. It was demonstrated that HMGB3 regulated the WNT/β‑catenin signaling pathway under miR‑758 regulation. In summary, these observations suggested that miR‑758 is a tumor suppressor gene that can inhibit the metastatic phenotype of CC cells by negatively regulating HMGB3, which may present a path to novel therapeutic stratagems for CC therapy.
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View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Smith RA, Brooks D, Cokkinides V, Saslow D and Brawley OW: Cancer screening in the United States, 2013: A review of current American cancer society guidelines, current issues in cancer screening, and new guidance on cervical cancer screening and lung cancer screening. CA Cancer J Clin. 63:88–105. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Dai S, Lu Y, Long Y, Lai Y, Du P, Ding N and Yao D: Prognostic value of microRNAs in cervical carcinoma: A systematic review and meta-analysis. Oncotarget. 7:35369–35378. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Kanekura K, Nishi H, Isaka K and Kuroda M: MicroRNA and gynecologic cancers. J Obstet Gynaecol Res. 42:612–617. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Kwan JY, Psarianos P, Bruce JP, Yip KW and Liu FF: The complexity of microRNAs in human cancer. J Radiat Res. 57 (Suppl 1):i106–i111. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Liu J, Jiang J, Hui X, Wang W, Fang D and Ding L: Mir-758-5p suppresses glioblastoma proliferation, migration and invasion by targeting ZBTB20. Cell Physiol Biochem. 48:2074–2083. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Wang S and Jiang M: The long non-coding RNA-DANCR exerts oncogenic functions in non-small cell lung cancer via miR-758-3p. Biomed Pharmacother. 103:94–100. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Jiang D, Cho W, Li Z, Xu X, Qu Y, Jiang Z, Guo L and Xu G: MiR-758-3p suppresses proliferation, migration and invasion of hepatocellular carcinoma cells via targeting MDM2 and mTOR. Biomed Pharmacother. 96:535–544. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Meng X, Zhao Y, Wang J, Gao Z, Geng Q and Liu X: Regulatory roles of miRNA-758 and matrix extracellular phosphoglycoprotein in cervical cancer. Exp Ther Med. 14:2789–2794. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Zhang Z, Chang Y, Zhang J, Lu Y, Zheng L, Hu Y, Zhang F and Li X, Zhang W and Li X: HMGB3 promotes growth and migration in colorectal cancer by regulating WNT/β-catenin pathway. PLoS One. 12:e01797412017. View Article : Google Scholar : PubMed/NCBI

12 

Vu M, Yu J, Awolude OA and Chuang L: Cervical cancer worldwide. Curr Probl Cancer. 42:457–465. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Nemeth MJ, Curtis DJ, Kirby MR, Garrett-Beal LJ, Seidel NE, Cline AP and Bodine DM: Hmgb3: An HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood. 102:1298–1306. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Chen X and Zeng L: Ginkgo biloba extract 761 enhances 5-fluorouracil chemosensitivity in colorectal cancer cells through regulation of high mobility group-box 3 expression. Am J Transl Res. 10:1773–1783. 2018.PubMed/NCBI

15 

Yamada Y, Nishikawa R, Kato M, Okato A, Arai T, Kojima S, Yamazaki K, Naya Y, Ichikawa T and Seki N: Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis. J Hum Genet. 63:195–205. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Gao J, Zou Z, Gao J, Zhang H, Lin Z, Zhang Y, Luo X, Liu C, Xie J and Cai C: Increased expression of HMGB3: A novel independent prognostic marker of worse outcome in patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 8:345–352. 2015.PubMed/NCBI

17 

Song N, Liu B, Wu JL, Zhang RF, Duan L, He WS and Zhang CM: Prognostic value of HMGB3 expression in patients with non-small cell lung cancer. Tumour Biol. 34:2599–2603. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Bahrami A, Hasanzadeh M, ShahidSales S, Yousefi Z, Kadkhodayan S, Farazestanian M, Joudi Mashhad M, Gharib M, Mahdi Hassanian S and Avan A: Clinical significance and prognosis value of Wnt signaling pathway in cervical cancer. J Cell Biochem. 118:3028–3033. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song T, Hou X and Lin B: MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway. Oncol Lett 18: 1786-1792, 2019.
APA
Song, T., Hou, X., & Lin, B. (2019). MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway. Oncology Letters, 18, 1786-1792. https://doi.org/10.3892/ol.2019.10470
MLA
Song, T., Hou, X., Lin, B."MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway". Oncology Letters 18.2 (2019): 1786-1792.
Chicago
Song, T., Hou, X., Lin, B."MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway". Oncology Letters 18, no. 2 (2019): 1786-1792. https://doi.org/10.3892/ol.2019.10470
Copy and paste a formatted citation
x
Spandidos Publications style
Song T, Hou X and Lin B: MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway. Oncol Lett 18: 1786-1792, 2019.
APA
Song, T., Hou, X., & Lin, B. (2019). MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway. Oncology Letters, 18, 1786-1792. https://doi.org/10.3892/ol.2019.10470
MLA
Song, T., Hou, X., Lin, B."MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway". Oncology Letters 18.2 (2019): 1786-1792.
Chicago
Song, T., Hou, X., Lin, B."MicroRNA‑758 inhibits cervical cancer cell proliferation and metastasis by targeting HMGB3 through the WNT/β‑catenin signaling pathway". Oncology Letters 18, no. 2 (2019): 1786-1792. https://doi.org/10.3892/ol.2019.10470
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