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Article Open Access

Exploration of the hub genes and miRNAs in lung adenocarcinoma

  • Authors:
    • Yuanyuan Zhai
    • Yingli Chen
    • Qianzhong Li
    • Luqiang Zhang
  • View Affiliations / Copyright

    Affiliations: Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University, Hohhot, Inner Mongolia 010021, P.R. China
    Copyright: © Zhai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1713-1722
    |
    Published online on: June 14, 2019
       https://doi.org/10.3892/ol.2019.10478
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Abstract

In order to investigate the oncogenic mechanisms of lung adenocarcinoma (LUAD), hub genes can be identified by constructing co‑expression networks, and the potential linkages between hub genes, transcription factors (TFs) and microRNAs (miRNAs/miRs) can be visualized and identified. In the present study, a total of 12 co‑expressed modules were constructed, and 9 of these were significantly correlated with clinical traits in LUAD. The differentially expressed genes and differentially expressed miRNAs were determined, and the targets of differentially expressed miRNA were identified from the hub genes or TFs. The results of the present study demonstrated that 10 hub genes and 12 TFs are the predicted targets for the 5 and 8 differentially expressed miRNAs, respectively. Genes in pink and red modules, which have a high correlation with the clinical trait of days to death, are significantly enriched in ‘nucleosome assembly’ and ‘microtubule‑based process’, respectively. These results indicated that miR‑206, miR‑137, miR‑153, hub genes and enriched TFs in the pink and red modules exert a potentially pivotal function in the development of LUAD.
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1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Youlden DR, Cramb SM and Baade PD: The international epidemiology of lung cancer: Geographical distribution and secular trends. J Thorac Oncol. 8:819–831. 2008. View Article : Google Scholar

3 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Mullany LE, Herrick JS, Wolff RK, Stevens JR, Samowitz W and Slattery ML: MicroRNA-transcription factor interactions and their combined effect on target gene expression in colon cancer cases. Genes Chromosomes Cancer. 57:192–202. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Fang X, Sastry A, Mih N, Kim D, Tan J, Yurkovich JT, Lloyd CJ, Gao Y, Yang L and Palsson BO: Global transcriptional regulatory network for Escherichia coli robustly connects gene expression to transcription factor activities. Proc Natl Acad Sci USA. 114:10286–10291. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Ruan J, Dean AK and Zhang W: A general co-expression network-based approach to gene expression analysis: Comparison and applications. BMC Syst Biol. 4:82010. View Article : Google Scholar : PubMed/NCBI

7 

Miller JA, Horvath S and Geschwind DH: Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc Natl Acad Sci USA. 107:12698–12703. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Carlson MR, Zhang B, Fang Z, Mischel PS, Horvath S and Nelson SF: Gene connectivity, function, and sequence conservation: Predictions from modular yeast co-expression networks. BMC Genomics. 7:402006. View Article : Google Scholar : PubMed/NCBI

9 

Oldham MC, Konopka G, Iwamoto K, Langfelder P, Kato T, Horvath S and Geschwind DH: Functional organization of the transcriptome in human brain. Nat Neurosci. 11:1271–1282. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Udyavar AR, Hoeksema MD, Clark JE, Zou Y, Tang Z, Li Z, Li M, Chen H, Statnikov A, Shyr Y, et al: Co-expression network analysis identifies SpleenTyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer. BMC Syst Bio. 5 (Suuppl):S12013. View Article : Google Scholar

11 

Tian F, Zhao J, Fan X and Kang Z: Weighted gene co-expression network analysis in identification of metastasis-related genes of lung squamous cell carcinoma based on the Cancer Genome Atlas database. J Thorac Dis. 9:42–53. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Gou Y and Xing Y: Weighted gene co-expression network analysis of pneumocytes under exposure to a carcinogenic dose of chloroprene. Life Sci. 151:339–347. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Anders S and Huber W: Differential expression analysis for sequence count data. Genome Biol. 11:R1062010. View Article : Google Scholar : PubMed/NCBI

14 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

15 

Huang DW, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID Bioinformatics Resources: Expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 35:W169–W175. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Dweep H, Sticht C, Pandey P and Gretz N: miRWalk-database: Prediction of possible miRNA binding sites by ‘walking’ the genes of three genomes. J Biomed Inform. 5:839–847. 2011. View Article : Google Scholar

17 

Chou CH, Shrestha S, Yang CD, Chang NW, Lin YL, Liao KW, Huang WC, Sun TH, Tu SJ, Lee WH, et al: miRTarBase update 2018: A resource for experimentally validated microRNA-target interactions. Nucleic Acids Res. 46:D296–D302. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Xing Y, Zhang J, Lu L, Li D, Wang Y, Huang S, Li C, Zhang Z, Li J and Meng A: Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene coexpression network analysis. Mol Med Rep. 13:107–116. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Subudhi AK, Boopathi PA, Pandey I, Kaur R, Middha S, Acharya J, Kochar SK, Kochar DK and Das A: Disease specific modules and hub genes for intervention strategies: A co-expression network based approach for Plasmodium falciparum clinical isolates. Infect Genet Evol. 35:96–108. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Ha M and Kim VN: Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 15:509–524. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich R, Negrini M and Croce CM: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA. 101:2999–3004. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Hong QY, Wu GM, Qian GS, Hu CP, Zhou JY, Chen LA, Li WM, Li SY, Wang K, Wang Q, et al: Prevention and management of lung cancer in China. Cancer. 121 (Suppl 17):S3080–S3088. 2015. View Article : Google Scholar

24 

Al-Rakan MA, Hendrayani SF and Aboussekhra A: CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6. BMC Cancer. 16:5752016. View Article : Google Scholar : PubMed/NCBI

25 

Wang Y, McKay JD, Rafnar T, Wang Z, Timofeeva MN, Broderick P, Zong X, Laplana M, Wei Y, Han Y, et al: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet. 46:736–741. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Siołek M, Cybulski C, Gąsior-Perczak D, Kowalik A, Kozak-Klonowska B, Kowalska A, Chłopek M, Kluźniak W, Wokołorczyk D, Pałyga I, et al: CHEK2 mutations and the risk of papillary thyroid cancer. Int J Cancer. 137:548–552. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Leedom TP, LaDuca H, McFarland R, Li S, Dolinsky JS and Chao EC: Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers. Cancer Genet. 209:403–407. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Nquyen MH, Ueda K, Nakamura Y and Daigo Y: Identification of a novel oncogene, MMS22L, involved in lung and esophageal carcinogenesis. Int J Oncol. 4:1285–1296. 2012.

29 

Piwko W, Mlejnkova LJ, Mutreja K, Ranjha L, Stafa D, Smirnov A, Brodersen MM, Zellweger R, Sturzenegger A, Janscak P, et al: The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress. EMBO J. 35:2584–2601. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Chen X, Tong ZK and Zhou JY, Yao YK, Zhang SM and Zhou JY: MicroRNA-206 inhibits the viability and migration of human lung adenocarcinoma cells partly by targeting MET. Oncol Lett. 12:1171–1177. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Chen QY, Jiao DM, Yan L, Wu YQ, Hu HZ, Song J, Yan J, Wu LJ, Xu LQ and Shi JG: Comprehensive gene and microRNA expression profiling reveals miR-206 inhibits MET in lung cancer metastasis. Mol Biosyst. 11:2290–2302. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Su TJ, Ku WH, Chen HY, Hsu YC, Hong QS, Chang GC, Yu SL and Chen JJ: Oncogenic miR-137 contributes to cisplatin resistance via repressing CASP3 in lung adenocarcinoma. Am J Cancer Res. 6:1317–1330. 2016.PubMed/NCBI

33 

Chang TH, Tsai MF, Gow CH, Wu SG, Liu YN, Chang YL, Yu SL, Tsai HC, Lin SW, Chen YW, et al: Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C. Cancer Lett. 402:190–202. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Chen WJ, Zhang EN, Zhong ZK, Jiang MZ, Yang XF, Zhou DM and Wang XW: MicroRNA-153 expression and prognosis in non-small cell lung cancer. Int J Clin Exp Pathol. 8:8671–8675. 2015.PubMed/NCBI

35 

Shan N, Shen L, Wang J, He D and Duan C: MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19. Biochem Biophys Res Commun. 456:385–391. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Boudjadi S, Chatterjee B, Sun W, Vemu P and Barr FG: The expression and function of PAX3 in development and disease. Gene. 666:145–157. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Pastuszak-Lewandoska D, Domańska D, Czarnecka KH, Kordiak J, Migdalska-Sęk M, Nawrot E, Kiszałkiewicz J, Antczak A, Górski P and Brzeziańska E: Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. PLoS One. 9:e1042652014. View Article : Google Scholar : PubMed/NCBI

38 

Cao S, Yan Y, Zhang X, Zhang K, Liu C, Zhao G, Han J, Dong Q, Shen B, Wu A and Cui J: EGF stimulates cyclooxygenase-2 expression through the STAT5 signaling pathway in human lung adenocarcinoma A549 cells. Int J Oncol. 39:383–391. 2011.PubMed/NCBI

39 

Silva FP, Hamamoto R and Nakamura Y: WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation. Neoplasia. 7:348–355. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, et al: Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics. 13:397–406. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Loucks CM, Bialas NJ, Dekkers MP, Walker DS, Grundy LJ, Li C, Inglis PN, Kida K, Schafer WR, Blacque OE, et al: PACRG, a protein linked to ciliary motility, mediates cellular signaling. Mol Biol Cell. 27:2133–2144. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Toma MI, Wuttig D, Kaiser S, Herr A, Weber T, Zastrow S, Koch R, Meinhardt M, Baretton GB, Wirth MP and Fuessel S: PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome. Gene Chromosome Canc. 3:265–273. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhai Y, Chen Y, Li Q and Zhang L: Exploration of the hub genes and miRNAs in lung adenocarcinoma. Oncol Lett 18: 1713-1722, 2019.
APA
Zhai, Y., Chen, Y., Li, Q., & Zhang, L. (2019). Exploration of the hub genes and miRNAs in lung adenocarcinoma. Oncology Letters, 18, 1713-1722. https://doi.org/10.3892/ol.2019.10478
MLA
Zhai, Y., Chen, Y., Li, Q., Zhang, L."Exploration of the hub genes and miRNAs in lung adenocarcinoma". Oncology Letters 18.2 (2019): 1713-1722.
Chicago
Zhai, Y., Chen, Y., Li, Q., Zhang, L."Exploration of the hub genes and miRNAs in lung adenocarcinoma". Oncology Letters 18, no. 2 (2019): 1713-1722. https://doi.org/10.3892/ol.2019.10478
Copy and paste a formatted citation
x
Spandidos Publications style
Zhai Y, Chen Y, Li Q and Zhang L: Exploration of the hub genes and miRNAs in lung adenocarcinoma. Oncol Lett 18: 1713-1722, 2019.
APA
Zhai, Y., Chen, Y., Li, Q., & Zhang, L. (2019). Exploration of the hub genes and miRNAs in lung adenocarcinoma. Oncology Letters, 18, 1713-1722. https://doi.org/10.3892/ol.2019.10478
MLA
Zhai, Y., Chen, Y., Li, Q., Zhang, L."Exploration of the hub genes and miRNAs in lung adenocarcinoma". Oncology Letters 18.2 (2019): 1713-1722.
Chicago
Zhai, Y., Chen, Y., Li, Q., Zhang, L."Exploration of the hub genes and miRNAs in lung adenocarcinoma". Oncology Letters 18, no. 2 (2019): 1713-1722. https://doi.org/10.3892/ol.2019.10478
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