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Article Open Access

MicroRNA‑181 inhibits glioblastoma cell growth by directly targeting CCL8

  • Authors:
    • Fengyu Zhai
    • Xinfeng Chen
    • Qianyi He
    • Heng Zhang
    • Yongqiang Hu
    • Dan Wang
    • Shasha Liu
    • Yi Zhang
  • View Affiliations / Copyright

    Affiliations: Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Radiotherapy, Puyang Oil Field General Hospital, Puyang, Henan 457000, P.R. China
    Copyright: © Zhai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1922-1930
    |
    Published online on: June 14, 2019
       https://doi.org/10.3892/ol.2019.10480
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Abstract

MicroRNAs (miRNAs/miRs), including miR‑181, are closely linked to the development and progression of glioblastoma. However, the function of miR‑181 in glioblastoma has not been fully clarified. The aim of the present study was to investigate the role of miR‑181 in glioblastoma. miR‑181 was revealed to be downregulated in glioblastoma tissues and cell lines, and associated with poor prognosis in patients with glioblastoma. Overexpression of miR‑181 inhibited glioblastoma cell proliferation, invasion and migration, arrested glioblastoma cell cycle in the G1 phase and induced glioblastoma cell apoptosis. miR‑181 was demonstrated to decrease expression of C‑C motif chemokine ligand 8 (CCL8) by directly interacting with its 3'‑untranslated region. Overexpression of CCL8 inversely reversed the proliferation, invasion and migration‑promoting effects of miR‑181 in glioblastoma cells. Furthermore, CCL8 was upregulated in glioblastoma tissues and was negatively correlated with miR‑181 expression. These results indicate that miR‑181 is a potential molecular biomarker or therapeutic target in the clinical management of glioblastoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhai F, Chen X, He Q, Zhang H, Hu Y, Wang D, Liu S and Zhang Y: MicroRNA‑181 inhibits glioblastoma cell growth by directly targeting CCL8. Oncol Lett 18: 1922-1930, 2019.
APA
Zhai, F., Chen, X., He, Q., Zhang, H., Hu, Y., Wang, D. ... Zhang, Y. (2019). MicroRNA‑181 inhibits glioblastoma cell growth by directly targeting CCL8. Oncology Letters, 18, 1922-1930. https://doi.org/10.3892/ol.2019.10480
MLA
Zhai, F., Chen, X., He, Q., Zhang, H., Hu, Y., Wang, D., Liu, S., Zhang, Y."MicroRNA‑181 inhibits glioblastoma cell growth by directly targeting CCL8". Oncology Letters 18.2 (2019): 1922-1930.
Chicago
Zhai, F., Chen, X., He, Q., Zhang, H., Hu, Y., Wang, D., Liu, S., Zhang, Y."MicroRNA‑181 inhibits glioblastoma cell growth by directly targeting CCL8". Oncology Letters 18, no. 2 (2019): 1922-1930. https://doi.org/10.3892/ol.2019.10480
Copy and paste a formatted citation
x
Spandidos Publications style
Zhai F, Chen X, He Q, Zhang H, Hu Y, Wang D, Liu S and Zhang Y: MicroRNA‑181 inhibits glioblastoma cell growth by directly targeting CCL8. Oncol Lett 18: 1922-1930, 2019.
APA
Zhai, F., Chen, X., He, Q., Zhang, H., Hu, Y., Wang, D. ... Zhang, Y. (2019). MicroRNA‑181 inhibits glioblastoma cell growth by directly targeting CCL8. Oncology Letters, 18, 1922-1930. https://doi.org/10.3892/ol.2019.10480
MLA
Zhai, F., Chen, X., He, Q., Zhang, H., Hu, Y., Wang, D., Liu, S., Zhang, Y."MicroRNA‑181 inhibits glioblastoma cell growth by directly targeting CCL8". Oncology Letters 18.2 (2019): 1922-1930.
Chicago
Zhai, F., Chen, X., He, Q., Zhang, H., Hu, Y., Wang, D., Liu, S., Zhang, Y."MicroRNA‑181 inhibits glioblastoma cell growth by directly targeting CCL8". Oncology Letters 18, no. 2 (2019): 1922-1930. https://doi.org/10.3892/ol.2019.10480
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