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Review Open Access

Metabolic reprogramming and its clinical application in thyroid cancer (Review)

  • Authors:
    • Shi-Shuai Wen
    • Ting-Ting Zhang
    • Di-Xin Xue
    • Wei-Li Wu
    • Yu-Long Wang
    • Yu Wang
    • Qing-Hai Ji
    • Yong-Xue Zhu
    • Ning Qu
    • Rong-Liang Shi
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China, Department of General Surgery, Τhe Third Affiliated Hospital of Wenzhou Medical University, Rui'an, Zhejiang 325200, P.R. China
    Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1579-1584
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    Published online on: June 18, 2019
       https://doi.org/10.3892/ol.2019.10485
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Abstract

Warburg found that tumor cells exhibit high‑level glycolysis, even under aerobic condition, which is known as the ‘Warburg effect’. As systemic changes in the entire metabolic network are gradually revealed, it is recognized that metabolic reprogramming has gone far beyond the imagination of Warburg. Metabolic reprogramming involves an active change in cancer cells to adapt to their biological characteristics. Thyroid cancer is a common endocrine malignant tumor whose metabolic characteristics have been studied in recent years. Some drugs targeting tumor metabolism are under clinical trial. This article reviews the metabolic changes and mechanisms in thyroid cancer, aiming to find metabolic‑related molecules that could be potential markers to predict prognosis and metabolic pathways, or could serve as therapeutic targets. Our review indicates that knowledge in metabolic alteration has potential contributions in the diagnosis, treatment and prognostic evaluation of thyroid cancer, but further studies are needed for verification as well.
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Copy and paste a formatted citation
Spandidos Publications style
Wen S, Zhang T, Xue D, Wu W, Wang Y, Wang Y, Ji Q, Zhu Y, Qu N, Shi R, Shi R, et al: Metabolic reprogramming and its clinical application in thyroid cancer (Review). Oncol Lett 18: 1579-1584, 2019.
APA
Wen, S., Zhang, T., Xue, D., Wu, W., Wang, Y., Wang, Y. ... Shi, R. (2019). Metabolic reprogramming and its clinical application in thyroid cancer (Review). Oncology Letters, 18, 1579-1584. https://doi.org/10.3892/ol.2019.10485
MLA
Wen, S., Zhang, T., Xue, D., Wu, W., Wang, Y., Wang, Y., Ji, Q., Zhu, Y., Qu, N., Shi, R."Metabolic reprogramming and its clinical application in thyroid cancer (Review)". Oncology Letters 18.2 (2019): 1579-1584.
Chicago
Wen, S., Zhang, T., Xue, D., Wu, W., Wang, Y., Wang, Y., Ji, Q., Zhu, Y., Qu, N., Shi, R."Metabolic reprogramming and its clinical application in thyroid cancer (Review)". Oncology Letters 18, no. 2 (2019): 1579-1584. https://doi.org/10.3892/ol.2019.10485
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Spandidos Publications style
Wen S, Zhang T, Xue D, Wu W, Wang Y, Wang Y, Ji Q, Zhu Y, Qu N, Shi R, Shi R, et al: Metabolic reprogramming and its clinical application in thyroid cancer (Review). Oncol Lett 18: 1579-1584, 2019.
APA
Wen, S., Zhang, T., Xue, D., Wu, W., Wang, Y., Wang, Y. ... Shi, R. (2019). Metabolic reprogramming and its clinical application in thyroid cancer (Review). Oncology Letters, 18, 1579-1584. https://doi.org/10.3892/ol.2019.10485
MLA
Wen, S., Zhang, T., Xue, D., Wu, W., Wang, Y., Wang, Y., Ji, Q., Zhu, Y., Qu, N., Shi, R."Metabolic reprogramming and its clinical application in thyroid cancer (Review)". Oncology Letters 18.2 (2019): 1579-1584.
Chicago
Wen, S., Zhang, T., Xue, D., Wu, W., Wang, Y., Wang, Y., Ji, Q., Zhu, Y., Qu, N., Shi, R."Metabolic reprogramming and its clinical application in thyroid cancer (Review)". Oncology Letters 18, no. 2 (2019): 1579-1584. https://doi.org/10.3892/ol.2019.10485
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