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Article Open Access

Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis

  • Authors:
    • Kok‑Tong Tan
    • Ping‑Wen Chen
    • Shiming Li
    • Te‑Min Ke
    • Sheng‑Hao Lin
    • Ching‑Chieh Yang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tungs' Taichung Metro Harbor Hospital, Taichung 433, Taiwan, R.O.C., Institute of Biomedical Science, National Chung‑Hsing University, Taichung 402, Taiwan, R.O.C., Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang, Hubei 438000, P.R. China, Department of Radiation Oncology, Chi‑Mei Medical Center, Tainan 710, Taiwan, R.O.C., Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan, R.O.C.
    Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1631-1640
    |
    Published online on: June 19, 2019
       https://doi.org/10.3892/ol.2019.10499
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Abstract

Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study aimed to investigate the antitumor effects and molecular mechanisms of pterostilbene in the human lung squamous cell carcinoma (SqCC) cell line, H520. The results of the present study indicate that pterostilbene significantly reduced cell viability and induced S phase arrest, and that treatment with pterostilbene was associated with the downregulation of cyclin A and cyclin E, as with the upregulation of p21 and p27 expression in H520 cells. In the apoptosis analysis, pterostilbene induced S phase accumulation and the activation of caspase‑3, ‑8 and ‑9 in H520 cells, potentially through the activation of extrinsic and intrinsic apoptotic pathways. Additionally, the in vivo study demonstrated that pterostilbene effectively inhibited lung SqCC growth in a H520 xenograft model. Given the in vitro and in vivo antitumor effects of pterostilbene demonstrated in the present study, pterostilbene may serve a novel and effective therapeutic agent to for patients with SqCC.
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Copy and paste a formatted citation
Spandidos Publications style
Tan KT, Chen PW, Li S, Ke TM, Lin SH and Yang CC: Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis. Oncol Lett 18: 1631-1640, 2019.
APA
Tan, K., Chen, P., Li, S., Ke, T., Lin, S., & Yang, C. (2019). Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis. Oncology Letters, 18, 1631-1640. https://doi.org/10.3892/ol.2019.10499
MLA
Tan, K., Chen, P., Li, S., Ke, T., Lin, S., Yang, C."Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis". Oncology Letters 18.2 (2019): 1631-1640.
Chicago
Tan, K., Chen, P., Li, S., Ke, T., Lin, S., Yang, C."Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis". Oncology Letters 18, no. 2 (2019): 1631-1640. https://doi.org/10.3892/ol.2019.10499
Copy and paste a formatted citation
x
Spandidos Publications style
Tan KT, Chen PW, Li S, Ke TM, Lin SH and Yang CC: Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis. Oncol Lett 18: 1631-1640, 2019.
APA
Tan, K., Chen, P., Li, S., Ke, T., Lin, S., & Yang, C. (2019). Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis. Oncology Letters, 18, 1631-1640. https://doi.org/10.3892/ol.2019.10499
MLA
Tan, K., Chen, P., Li, S., Ke, T., Lin, S., Yang, C."Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis". Oncology Letters 18.2 (2019): 1631-1640.
Chicago
Tan, K., Chen, P., Li, S., Ke, T., Lin, S., Yang, C."Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis". Oncology Letters 18, no. 2 (2019): 1631-1640. https://doi.org/10.3892/ol.2019.10499
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