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Case Report Open Access

Mixed adenoendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review

  • Authors:
    • Liang Zhang
    • Zhengtao Yang
    • Qing Chen
    • Mengxia Li
    • Xiaolu Zhu
    • Dalong Wan
    • Haiyang Xie
    • Shusen Zheng
  • View Affiliations / Copyright

    Affiliations: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China, Department of Pathology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1585-1596
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    Published online on: June 20, 2019
       https://doi.org/10.3892/ol.2019.10502
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Abstract

Neuroendocrine neoplasm (NEN) comprises a group of tumors that exhibit neuroendocrine phenotypes. NEN is subclassified into neuroendocrine tumor (NET), neuroendocrine carcinoma (NEC) and mixed adenoendocrine carcinoma (MANEC), based on histopathological parameters. NEN in the extrahepatic biliary tract (EHBT) is uncommon. Little is known about its clinicopathological features and prognostic indicators. The present study presented a case of MANEC in the distal common bile duct (CBD) and reviewed previous cases of NENs in the EHBT to characterize the clinical settings of this disease entity and to identify influencing factors of survival outcomes. A 64‑year‑old Chinese woman presented with abdominal pain and jaundice. Imaging studies demonstrated malignant stenosis in the distal CBD. Bile duct brush cytology revealed small clusters of atypical cells. Following an initial diagnosis of distal cholangiocarcinoma (CCA), the patient underwent pancreaticoduodenectomy. Histological analysis combined with immunohistochemical investigation of the resected specimen revealed a collision tumor that was composed of poorly differentiated adenocarcinoma and NEC. Each histological component accounted for >30% of the tumor. The definitive diagnosis was a MANEC in the distal CBD. Multiple intrahepatic and pulmonary metastases were observed postoperatively over 8 months. The patient succumbed to the disease 12 months after surgery. In conclusion, NEN occurs infrequently in the EHBT, with NET being the predominant type. NEN in the EHBT is extremely challenging to diagnose preoperatively due to its tendency to mimic CCA. Patients with NEN in the EHBT exhibited extremely distinct oncology outcomes according to pathological types. Additionally, old age (>60 years) and the presence of tumor recurrence were associated with decreased survival of patients with NEN.
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1 

Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, et al: Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol. 9:61–72. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Uccella S, La Rosa S, Volante M and Papotti M: Immunohistochemical biomarkers of gastrointestinal, pancreatic, pulmonary, and thymic neuroendocrine neoplasms. Endocr Pathol. 29:150–168. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Bosman FT, Carneiro F, Hruban RH and Theise ND: WHO Classification of Tumours of the Digestive System. Fourth Edition. IARC; Lyon: 2010

4 

La Rosa S, Marando A, Sessa F and Capella C: Mixed adenoneuroendocrine carcinomas (MANECs) of the gastrointestinal tract: An update. Cancers (Basel). 4:11–30. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Vakili K and Pomfret EA: Biliary anatomy and embryology. Surg Clin North Am. 881159–1174. (vii)2008. View Article : Google Scholar : PubMed/NCBI

6 

Rizvi S, Khan SA, Hallemeier CL, Kelley RK and Gores GJ: Cholangiocarcinoma-evolving concepts and therapeutic strategies. Nat Rev Clin Oncol. 15:95–111. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A and Evans DB: One hundred years after ‘carcinoid’: Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 26:3063–3072. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Michalopoulos N, Papavramidis TS, Karayannopoulou G, Pliakos I, Papavramidis ST and Kanellos I: Neuroendocrine tumors of extrahepatic biliary tract. Pathol Oncol Res. 20:765–775. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Sasatomi E, Nalesnik MA and Marsh JW: Neuroendocrine carcinoma of the extrahepatic bile duct: Case report and literature review. World J Gastroenterol. 19:4616–4623. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Zhang L, Wan D, Bao L, Chen Q, Xie H, Xu S and Lin S: Neuroendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review. Medicine (Baltimore). 97:e114872018. View Article : Google Scholar : PubMed/NCBI

11 

Acosta AM and Wiley EL: Primary biliary mixed adenoneuroendocrine carcinoma (MANEC): A short review. Arch Pathol Lab Med. 140:1157–1162. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Adsay V: Ki67 labeling index in neuroendocrine tumors of the gastrointestinal and pancreatobiliary tract: To count or not to count is not the question, but rather how to count. Am J Surg Pathol. 36:1743–1746. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Izumo W, Higuchi R, Yazawa T, Uemura S, Matsunaga Y, Shiihara M, Furukawa T and Yamamoto M: A long-term recurrence-free survival of a patient with the mixed adeno-neuroendocrine bile duct carcinoma: A case report and review of the literature. Int J Surg Case Rep. 39:43–50. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Komo T, Kohashi T, Nakashima A, Ohmori I, Hihara J, Mukaida H, Kaneko M and Hirabayashi N: Mixed adenoneuroendocrine carcinoma of the distal bile duct: A case report. Int J Surg Case Rep. 39:203–207. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Lee SW, Lee IS, Cho YK, Park JM, Kim SW, Choi MG, Choi KY, Lee MA, Hong TH, You YK and Jung ES: A case of mixed adenoneuroendocrine carcinoma of the common bile duct: Initially diagnosed as cholangiocarcinoma. Korean J Pathol. 48:445–448. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Linder R, Dorfman T, Ben-Ishay O, Kakiashvili E, Velodavsky E and Kluger Y: Mixed neuroendocrine tumor of the common bile duct. JOP. 14:71–73. 2013.PubMed/NCBI

17 

Masui T, Doi R, Kawaguchi Y, Iwanaga Y, Ito T, Koizumi M and Uemoto S: Adenoendocrine cell carcinoma of the extrahepatic bile duct: A case report and review of the literature. Clin J Gastroenterol. 4:174–178. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Onishi I, Kitagawa H, Harada K, Maruzen S, Sakai S, Makino I, Hayashi H, Nakagawara H, Tajima H, Takamura H, et al: Intraductal papillary neoplasm of the bile duct accompanying biliary mixed adenoneuroendocrine carcinoma. World J Gastroenterol. 19:3161–3164. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Priyanka Akhilesh S, Kamal Sunder Y, Chandralekha T, Samir P and Prasad Kashinath W: Common hepatic duct mixed adenoneuroendocrine carcinoma masquerading as cholangiocarcinoma. Case Rep Gastrointest Med. 2016:48270502016.PubMed/NCBI

20 

Wysocki J, Agarwal R, Bratton L, Nguyen J, Weidenhaft MC, Shores N and Kimbrell HZ: Mixed large cell neuroendocrine carcinoma and adenocarcinoma with spindle cell and clear cell features in the extrahepatic bile duct. Case Rep Pathol. 2014:3479492014.PubMed/NCBI

21 

Dancygier H, Klein U, Leuschner U, Hübner K and Classen M: Somatostatin-containing cells in the extrahepatic biliary tract of humans. Gastroenterology. 86:892–896. 1984.PubMed/NCBI

22 

Oshiro H, Matsuo K, Mawatari H, Inayama Y, Yamanaka S, Nagahama K, Endo I, Shimada H, Nakajima A and Kubota K: Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. Pathol Int. 58:780–786. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Harada K, Sato Y, Ikeda H, Maylee H, Igarashi S, Okamura A, Masuda S and Nakanuma Y: Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs. Virchows Arch. 460:281–289. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Harada K, Sato Y, Ikeda H, Hsu M, Igarashi S and Nakanuma Y: Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours. J Clin Pathol. 66:386–391. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Mia-Jan K, Munkhdelger J, Lee MR, Ji SY, Kang TY, Choi E and Cho MY: Expression of CD133 in neuroendocrine neoplasms of the digestive tract: A detailed immunohistochemical analysis. Tohoku J Exp Med. 229:301–309. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Scardoni M, Vittoria E, Volante M, Rusev B, Bersani S, Mafficini A, Gottardi M, Giandomenico V, Malleo G, Butturini G, et al: Mixed adenoneuroendocrine carcinomas of the gastrointestinal tract: Targeted next-generation sequencing suggests a monoclonal origin of the two components. Neuroendocrinology. 100:310–316. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Lewin K: Carcinoid tumors and the mixed (composite) glandular-endocrine cell carcinomas. Am J Surg Pathol. 11 (Suppl 1):S71–S86. 1987. View Article : Google Scholar

28 

Liu Z, Zhang DY, Lu Z, Zhang P, Sun WL, Ma X, Wu H, Wu BQ and Zhou S: Neuroendocrine tumor of the common bile duct: A case report and review of the literature. Onco Targets Ther. 11:2295–2301. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Squillaci S, Marchione R, Piccolomini M, Colombo F, Bucci F, Bruno M and Bisceglia M: Well-differentiated neuroendocrine carcinoma (malignant carcinoid) of the extrahepatic biliary tract: Report of two cases and literature review. APMIS. 118:543–556. 2010.PubMed/NCBI

30 

Zhan J, Bao G, Hu X, Gao W, Ruo X, Gong J, Zhu Q and Liu Y: Carcinoid tumor of the common bile duct in children: A case report. J Pediatr Surg. 45:2061–2063. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Cappell MS, Killeen TC and Jury R: Common bile duct carcinoid mimicking the clinical, EUS, and ERCP findings of cholangiocarcinoma: A rare but potentially curable cause of obstructive jaundice. Clin Gastroenterol Hepatol. 9:e112–e113. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Lee JH, Lee KG, Oh YH, Paik SS, Park HK and Lee KS: Carcinoid tumors of the extrahepatic biliary tract: Report of four cases. Surg Today. 41:430–435. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Bhalla P, Powle V, Shah RC and Jagannath P: Neuroendocrine tumor of common hepatic duct. Indian J Gastroenterol. 31:144–146. 2012. View Article : Google Scholar : PubMed/NCBI

34 

De Luca L, Tommasoni S, de Leone A, Bianchi ML, de Nictolis M and Baroncini D: Neuroendocrine tumor of the extrahepatic bile duct: A tumor in an unusual site visualized by cholangioscopy. Endoscopy. 45 (Suppl 2):E338–E339. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Jethava A, Muralidharan V, Mesologites T, Stoica-Mustafa E and Dasanu CA: An unusual presentation of a carcinoid tumor of the common bile duct. JOP. 14:85–87. 2013.PubMed/NCBI

36 

Yasuda T, Imai G, Takemoto M, Yamasaki M, Ishikawa H, Kitano M, Nakai T and Takeyama Y: Carcinoid tumor of the extrahepatic bile duct: Report of a case. Clin J Gastroenterol. 6:177–187. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Ayllon-Teran MD, Valverde-Martinez A, Diaz-Nieto R, Ciria-Bru R, Luque-Molina A, López-Cillero P and Briceño-Delgado J: Carcinoid tumor of the common bile duct. Rev Esp Enferm Dig. 106:560–561. 2014.PubMed/NCBI

38 

Khuroo S, Rashid A, Bali RS, Mushtaque M and Khuroo F: Carcinoid Klatskin tumour: A rare cause of obstructive jaundice. Australas Med J. 7:243–246. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Park SB, Moon SB, Ryu YJ, Hong J, Kim YH, Chae GB and Hong SK: Primary large cell neuroendocrine carcinoma in the common bile duct: First Asian case report. World J Gastroenterol. 20:18048–18052. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Yalav O, Ulku A, Demiryurek H and Doran F: A rare cause of bile duct obstruction in adolescence: Neuroendocrine tumor. Turk J Gastroenterol. 25 (Suppl 1):S311–S312. 2014. View Article : Google Scholar

41 

Kihara Y, Yokomizo H, Urata T, Nagamine M and Hirata T: A case report of primary neuroendocrine carcinoma of the perihilar bile duct. BMC Surg. 15:1252015. View Article : Google Scholar : PubMed/NCBI

42 

Banerjee JK, Saranga Bharathi R, Shrivastava S and Ranjan P: Neuroendocrine tumor of distal bile duct. Med J Armed Forces India. 72 (Suppl 1):S101–S104. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Hosoda K, Kobayashi A, Shimizu A, Kitagawa N, Ito T, Yamada A and Miyagawa S: Neuroendocrine tumor of the common bile duct. Surgery. 160:525–526. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Murakami M, Katayama K, Kato S, Fujimoto D, Morikawa M, Koneri K, Hirono Y and Goi T: Large-cell neuroendocrine carcinoma of the common bile duct: A case report and a review of literature. Surg Case Rep. 2:1412016. View Article : Google Scholar : PubMed/NCBI

45 

Oshiro Y, Gen R, Hashimoto S, Oda T, Sato T and Ohkohchi N: Neuroendocrine carcinoma of the extrahepatic bile duct: A case report. World J Gastroenterol. 22:6960–6964. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Raspanti C, Falco N, Silvestri V, Rotolo G, Bonventre S and Gulotta G: Neuroendocrine tumor of the common bile duct: Case report. G Chir. 37:275–280. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Abe T, Nirei A, Suzuki N, Todate Y, Azami A, Waragai M, Sato A, Takano Y, Nishino N, Sakuma H and Teranishi Y: Neuroendocrine tumor of the extrahepatic bile duct: A case report. Int J Surg Case Rep. 40:6–9. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Costin AI, Păun I, Păun M, Constantin VD and Vârcuş F: Primary neuroendocrine tumors-an extremely rare cause of obstruction of extrahepatic bile ducts: A case report. Rom J Morphol Embryol. 58:641–644. 2017.PubMed/NCBI

49 

Hoepfner L and White JA: Primary extrahepatic bile duct neuroendocrine tumor with obstructive jaundice masquerading as a Klatskin tumor. J Surg Case Rep. 2017:rjx1042017. View Article : Google Scholar : PubMed/NCBI

50 

Khan FA, Stevens-Chase A, Chaudhry R, Hashmi A, Edelman D and Weaver D: Extrahepatic biliary obstrution secondary to neuroendocrine tumor of the common hepatic duct. Int J Surg Case Rep. 30:46–49. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Sanchez Cabus S, Pittau G, Sebagh M and Cherqui D: Primary non-functioning neuroendocrine tumor of the extrahepatic bile duct. Rev Esp Enferm Dig. 109:228–229. 2017.PubMed/NCBI

52 

Sano I, Kuwatani M, Sugiura R, Kato S, Kawakubo K, Ueno T, Nakanishi Y, Mitsuhashi T, Hirata H, Haba S, et al: Hepatobiliary and pancreatic: A rare case of a well-differentiated neuroendocrine tumor in the bile duct with spontaneous regression diagnosed by EUS-FNA. J Gastroenterol Hepatol. 32:112017. View Article : Google Scholar : PubMed/NCBI

53 

Koo JY, Kim KH and Kim TN: Primary large cell neuroendocrine carcinoma of the common hepatic duct mimicking a Klatskin tumor. Korean J Intern Med. 34:452–453. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Oberg K, Knigge U, Kwekkeboom D and Perren A; ESMO Guidelines Working Group, : Neuroendocrine gastro-entero-pancreatic tumors: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 23 (Suppl 7):vii124–vii130. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Hong N, Kim HJ, Byun JH, Kim SY, Kim KW, Kim JH and Hong SM: Neuroendocrine neoplasms of the extrahepatic bile duct: Radiologic and clinical characteristics. Abdom Imaging. 40:181–191. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Sundin A, Arnold R, Baudin E, Cwikla JB, Eriksson B, Fanti S, Fazio N, Giammarile F, Hicks RJ, Kjaer A, et al: ENETS consensus guidelines for the standards of care in neuroendocrine tumors: Radiological, nuclear medicine & hybrid imaging. Neuroendocrinology. 105:212–244. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Perren A, Couvelard A, Scoazec JY, Costa F, Borbath I, Delle Fave G, Gorbounova V, Gross D, Grossma A, Jense RT, et al: ENETS consensus guidelines for the standards of care in neuroendocrine tumors: Pathology: Diagnosis and prognostic stratification. Neuroendocrinology. 105:196–200. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Kaltsas G, Caplin M, Davies P, Ferone D, Garcia-Carbonero R, Grozinsky-Glasberg S, Hörsch D, Tiensuu Janson E, Kianmanesh R, Kos-Kudla B, et al: ENETS consensus guidelines for the standards of care in neuroendocrine tumors: Pre- and perioperative therapy in patients with neuroendocrine tumors. Neuroendocrinology. 105:245–254. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Sorbye H, Welin S, Langer SW, Vestermark LW, Holt N, Osterlund P, Dueland S, Hofsli E, Guren MG, Ohrling K, et al: Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): The NORDIC NEC study. Ann Oncol. 24:152–160. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Brathwaite S, Yearsley MM, Bekaii-Saab T, Wei L, Schmidt CR, Dillhoff ME, Frankel WL, Hays JL, Wu C and Abdel-Misih S: Appendiceal mixed Adeno-Neuroendocrine carcinoma: A Population-based study of the surveillance, epidemiology, and end results registry. Front Oncol. 6:1482016. View Article : Google Scholar : PubMed/NCBI

61 

Rayhan N, Sano T, Qian ZR, Obari AK and Hirokawa M: Histological and immunohistochemical study of composite neuroendocrine-exocrine carcinomas of the stomach. J Med Invest. 52:191–202. 2005. View Article : Google Scholar : PubMed/NCBI

62 

La Rosa S, Marando A, Furlan D, Sahnane N and Capella C: Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: Insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers. Am J Surg Pathol. 36:601–611. 2012. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Zhang L, Yang Z, Chen Q, Li M, Zhu X, Wan D, Xie H and Zheng S: Mixed adenoendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review. Oncol Lett 18: 1585-1596, 2019.
APA
Zhang, L., Yang, Z., Chen, Q., Li, M., Zhu, X., Wan, D. ... Zheng, S. (2019). Mixed adenoendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review. Oncology Letters, 18, 1585-1596. https://doi.org/10.3892/ol.2019.10502
MLA
Zhang, L., Yang, Z., Chen, Q., Li, M., Zhu, X., Wan, D., Xie, H., Zheng, S."Mixed adenoendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review". Oncology Letters 18.2 (2019): 1585-1596.
Chicago
Zhang, L., Yang, Z., Chen, Q., Li, M., Zhu, X., Wan, D., Xie, H., Zheng, S."Mixed adenoendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review". Oncology Letters 18, no. 2 (2019): 1585-1596. https://doi.org/10.3892/ol.2019.10502
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Yang Z, Chen Q, Li M, Zhu X, Wan D, Xie H and Zheng S: Mixed adenoendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review. Oncol Lett 18: 1585-1596, 2019.
APA
Zhang, L., Yang, Z., Chen, Q., Li, M., Zhu, X., Wan, D. ... Zheng, S. (2019). Mixed adenoendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review. Oncology Letters, 18, 1585-1596. https://doi.org/10.3892/ol.2019.10502
MLA
Zhang, L., Yang, Z., Chen, Q., Li, M., Zhu, X., Wan, D., Xie, H., Zheng, S."Mixed adenoendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review". Oncology Letters 18.2 (2019): 1585-1596.
Chicago
Zhang, L., Yang, Z., Chen, Q., Li, M., Zhu, X., Wan, D., Xie, H., Zheng, S."Mixed adenoendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review". Oncology Letters 18, no. 2 (2019): 1585-1596. https://doi.org/10.3892/ol.2019.10502
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