Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2019 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2019 Volume 18 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effect of prophylactic TACE on 5‑year survival of patients with hepatocellular carcinoma after hepatectomy

  • Authors:
    • Shasha He
    • Xiaotang Fan
    • Hailin Ma
    • Hali Xiaerfuhazi
    • Aliya Rehato
    • Juan Feng
    • Xiujiang Shi
    • Fangping He
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, The Eighth Affiliated Hospital, Sun Yat‑Sen University, Shenzhen, Guangdong 518000, P.R. China, Department of Hepatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1824-1830
    |
    Published online on: June 21, 2019
       https://doi.org/10.3892/ol.2019.10517
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to establish a prediction index (PI) model for the 5‑year survival rate of patients with hepatitis B‑related hepatocellular carcinoma (HCC) after radical resection, and to evaluate the effect of prophylactic transcatheter arterial chemoembolization (TACE). A total of 201 patients with hepatitis B‑related HCC who had undergone radical hepatic resection at The First Affiliated Hospital of Xinjiang Medical University (Xinjiang, China) were enrolled, and the clinical, pathological and complete follow‑up data were collected. Univariate and multivariate Cox regression analyses were performed to identify which clinicopathological factors were considered significant risk factors and the PI model was established based on these factors. The receiver operating characteristic curve was generated, and the area under the curve (0.841) and the cut‑off value for PI were calculated. A Kaplan‑Meier plot was used for survival analysis and the log‑rank test was used to determine differences in survival. Cox regression analysis demonstrated that there were seven independent factors that may have affected the 5‑year survival of HCC patients: Neutrophil‑to‑lymphocyte ratio (NLR), maximum size of tumor (MTS), tumor histological grade (HG), positive resection margin (PRM), microvascular invasion (MVI), the amount of tumor (AT), and antivirus therapy (AVT). A PI model on 5‑year survival was established based on these factors, which was PI=0.32 x NLR + 0.39 x HG (high=1, medium=2, low=3) + 0.92 x PRM (yes=1, no=0) + 0.87 x MVI (yes=1, no=0) + 0.73 x AT (single=0, many=1) + 0.53 x MTS (≥5 cm=1, <5 cm=0)‑0.87 x AVT (yes=1, no=0). PI was an independent predictor for survival, with a cut‑off value of 2.75. For low‑risk patients (PI <2.75), there was no significant difference in cumulative survival between TACE and non‑TACE. For high‑risk patients (PI >2.75), the cumulative survival rates showed significant differences among patients who had received ≥3 TACE procedues, patients who had received <3 TACE procedures, and patients who had not undergone TACE. The PI model predicts the 5‑year survival rate of patients with hepatitis B‑related HCC. For high‑risk patients with a PI >2.75, if they had received ≥3 prophylactic TACE procedures, they demonstrated a more favorable outcome. For low‑risk patients (PI <2.75) with 1 or 2 risk factors, TACE is recommended 1‑2 times after surgery. TACE treatment is not required for low‑risk patients without any risk fctors. These results may contribute to the decision‑making process for whether prophylactic intervention is recommended after radical resection of HCC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Zhang XF, Qi X, Meng B, Liu C, Yu L, Wang B and Lv Y: Prognosis evaluation in alpha-fetoprotein negative hepatocellular carcinoma after hepatectomy: Comparison of five staging systems. Eur J Surg Oncol. 36:718–724. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Amarapurkar D, Han KH, Chan HL and Ueno Y; Asia-Pacific Working Party on Prevention of Hepatocellular C, : Application of surveillance programs for hepatocellular carcinoma in the Asia-Pacific Region. J Gastroenterol Hepatol. 24:955–961. 2009. View Article : Google Scholar : PubMed/NCBI

4 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Lai EC and Lau WY: The continuing challenge of hepatic cancer in Asia. Surgeon. 3:210–215. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Lau WY, Lai EC, Leung TW and Yu SC: Adjuvant intra-arterial iodine-131-labeled lipiodol for resectable hepatocellular carcinoma: A prospective randomized trial-update on 5-year and 10-year survival. Ann Surg. 247:43–48. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Cucchetti A, Zanello M, Cescon M, Ercolani G, Del Gaudio M, Ravaioli M, Grazi GL and Pinna AD: Improved diagnostic imaging and interventional therapies prolong survival after resection for hepatocellular carcinoma in cirrhosis: The university of bologna experience over 10 years. Ann Surg Oncol. 18:1630–1637. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Xie H, Wang H, An W, Ma W, Qi R, Yang B, Liu C, Gao Y, Xu B and Wang W: The efficacy of radiofrequency ablation combined with transcatheter arterial chemoembolization for primary hepatocellular carcinoma in a cohort of 487 patients. PLoS One. 9:e890812014. View Article : Google Scholar : PubMed/NCBI

9 

Lin Z, Ren Z and Xia J: Appraisal of postoperative transcatheter arterial chemoembolization (TACE) for prevention and treatment of hepatocellular carcinoma recurrence. Zhonghua Zhong Liu Za Zhi. 22:315–317. 2000.(In Chinese). PubMed/NCBI

10 

Lee JK, Chung YH, Song BC, Shin JW, Choi WB, Yang SH, Yoon HK, Sung KB, Lee YS and Suh DJ: Recurrences of hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization. J Gastroenterol Hepatol. 17:52–58. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Portolani N, Coniglio A, Ghidoni S, Giovanelli M, Benetti A, Tiberio GA and Giulini SM: Early and late recurrence after liver resection for hepatocellular carcinoma: Prognostic and therapeutic implications. Ann Surg. 243:229–235. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Samuel M, Chow PK, Chan Shih-Yen E, Machin D and Soo KC: Neoadjuvant and adjuvant therapy for surgical resection of hepatocellular carcinoma. Cochrane Database Syst Rev. 21:CD0011992009.

13 

Association HBaIDBoCM: Guidelines for prevention and treatment of chronic hepatitis B (2010 Edition). Chin J Hepatology Electronic Edition. 3:40–56. 2011.

14 

Sun HC, Zhang W, Qin LX, Zhang BH, Ye QH, Wang L, Ren N, Zhuang PY, Zhu XD, Fan J and Tang ZY: Positive serum hepatitis B e antigen is associated with higher risk of early recurrence and poorer survival in patients after curative resection of hepatitis B-related hepatocellular carcinoma. J Hepatol. 12:684–690. 2007. View Article : Google Scholar

15 

Roayaie S, Blume IN, Thung SN, Guido M, Fiel MI, Hiotis S, Labow DM, Llovet JM and Schwartz ME: A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma. Gastroenterology. 137:850–855. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Ardiles V, Sánchez Clariá R, Mazza OM, Ciardullo MA, Pekolj J and De Santibañes E: Prognostic factors after resection of hepatocellular carcinoma in the non-cirrhotic liver: Presentation of 51 cases. Cir Esp. 87:148–154. 2010.(In Spanish). View Article : Google Scholar : PubMed/NCBI

17 

Sumie S, Kuromatsu R, Okuda K, Ando E, Takata A, Fukushima N, Watanabe Y, Kojiro M and Sata M: Microvascular invasion in patients with hepatocellular carcinoma and its predictable clinicopathological factors. Ann Surg Oncol. 15:1375–1382. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Tian YH, Li JD, Peng Y, Li QL, Li DX and Li Q: Postoperative survival analysis of patients without liver cirrhosis. Chin J Digestive Surg. 10:305–306. 2011.

19 

Yamamoto J, Kosuge T, Takayama T, Shimada K, Yamasaki S, Ozaki H, Yamaguchi N and Makuuchi M: Recurrence of hepatocellular carcinoma after surgery. Br J Surg. 83:1219–1222. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Geschwind JF, Kudo M, Marrero JA, Venook AP, Chen XP, Bronowicki JP, Dagher L, Furuse J, Ladrón de Guevara L, Papandreou C, et al: TACE treatment in patients with sorafenib-treated unresectable hepatocellular carcinoma in clinical practice: Final analysis of GIDEON. Radiology. 279:630–640. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Hua YF, Li CD, Qiu F, Yu WM, Wu SD, Zhang GJ, Peng T and Yang HT: Transcatheter arterial chemoembolization after liver resection for hepatocellular carcinoma with portal vein tumor thrombus. Chin J Hepatobiliary Surg. 18:357–360. 2012.(In Chinese).

22 

Shah SA, Cleary SP, Wei AC, Yang I, Taylor BR, Hemming AW, Langer B, Grant DR, Greig PD and Gallinger S: Recurrence after liver resection for hepatocellular carcinoma: Risk factors, treatment and outcomes. Surgery. 141:330–339. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Tsurusaki M and Murakami T: Surgical and locoregional therapy of HCC: TACE. Liver Cancer. 4:165–175. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Zhu Q, Qiao GL, Yan JJ, Wu MC and Yan YQ: Prognosis after resection of early hepatocellular carcinoma in HBV-related cirrhotic patients. Chin J Hepatobiliary Surg. 20:258–264. 2014.

25 

Otto G, Heuschen U, Hofmann WJ, Krumm G, Hinz U and Herfarth C: Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: A retrospective analysis. Ann Surg. 227:424–432. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Pawlik TM, Delman KA, Vauthey JN, Nagorney DM, Ng IO, Ikai I, Yamaoka Y, Belghiti J, Lauwers GY, Poon RT and Abdalla EK: Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma. Liver Transpl. 11:1086–1092. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He S, Fan X, Ma H, Xiaerfuhazi H, Rehato A, Feng J, Shi X and He F: Effect of prophylactic TACE on 5‑year survival of patients with hepatocellular carcinoma after hepatectomy. Oncol Lett 18: 1824-1830, 2019.
APA
He, S., Fan, X., Ma, H., Xiaerfuhazi, H., Rehato, A., Feng, J. ... He, F. (2019). Effect of prophylactic TACE on 5‑year survival of patients with hepatocellular carcinoma after hepatectomy. Oncology Letters, 18, 1824-1830. https://doi.org/10.3892/ol.2019.10517
MLA
He, S., Fan, X., Ma, H., Xiaerfuhazi, H., Rehato, A., Feng, J., Shi, X., He, F."Effect of prophylactic TACE on 5‑year survival of patients with hepatocellular carcinoma after hepatectomy". Oncology Letters 18.2 (2019): 1824-1830.
Chicago
He, S., Fan, X., Ma, H., Xiaerfuhazi, H., Rehato, A., Feng, J., Shi, X., He, F."Effect of prophylactic TACE on 5‑year survival of patients with hepatocellular carcinoma after hepatectomy". Oncology Letters 18, no. 2 (2019): 1824-1830. https://doi.org/10.3892/ol.2019.10517
Copy and paste a formatted citation
x
Spandidos Publications style
He S, Fan X, Ma H, Xiaerfuhazi H, Rehato A, Feng J, Shi X and He F: Effect of prophylactic TACE on 5‑year survival of patients with hepatocellular carcinoma after hepatectomy. Oncol Lett 18: 1824-1830, 2019.
APA
He, S., Fan, X., Ma, H., Xiaerfuhazi, H., Rehato, A., Feng, J. ... He, F. (2019). Effect of prophylactic TACE on 5‑year survival of patients with hepatocellular carcinoma after hepatectomy. Oncology Letters, 18, 1824-1830. https://doi.org/10.3892/ol.2019.10517
MLA
He, S., Fan, X., Ma, H., Xiaerfuhazi, H., Rehato, A., Feng, J., Shi, X., He, F."Effect of prophylactic TACE on 5‑year survival of patients with hepatocellular carcinoma after hepatectomy". Oncology Letters 18.2 (2019): 1824-1830.
Chicago
He, S., Fan, X., Ma, H., Xiaerfuhazi, H., Rehato, A., Feng, J., Shi, X., He, F."Effect of prophylactic TACE on 5‑year survival of patients with hepatocellular carcinoma after hepatectomy". Oncology Letters 18, no. 2 (2019): 1824-1830. https://doi.org/10.3892/ol.2019.10517
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team