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Clinicopathological characteristics and survival of primary malignant melanoma of the esophagus

  • Authors:
    • Tadayoshi Hashimoto
    • Tomoki Makino
    • Makoto Yamasaki
    • Koji Tanaka
    • Yasuhiro Miyazaki
    • Tsuyoshi Takahashi
    • Yukinori Kurokawa
    • Masaaki Motoori
    • Yutaka Kimura
    • Kiyokazu Nakajima
    • Eiichi Morii
    • Masaki Mori
    • Yuichiro Doki
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan, Department of Surgery, Osaka General Medical Center, Osaka 558‑8558, Japan, Department of Surgery, Kindai University Faculty of Medicine, Osaka 589‑8511, Japan, Department of Pathology, Graduate School of Medicine, Osaka University, Osaka 565‑0871, Japan, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan
    Copyright: © Hashimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1872-1880
    |
    Published online on: June 21, 2019
       https://doi.org/10.3892/ol.2019.10519
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Abstract

Primary malignant melanoma of the esophagus (PMME) has been reported to be a rare and highly malignant disease, and to date a standard treatment strategy has not been established due to limited evidence. The aim of the present study was to investigate the clinicopathological characteristics of this extremely rare disease. A total of 6 out of 2,093 patients with PMME treated in our institution between 1995 and 2016 were retrospectively analyzed and their clinicopathological parameters including treatment course and long‑term survival were investigated. The major clinicopathological characteristics of patients were that they were >70 years of age, male sex, dysphagia at first diagnosis, and macroscopic black protruding tumors located in the lower third of the thoracic esophagus. Four of the five patients receiving pretherapeutic endoscopic biopsy were correctly diagnosed with PMME, and two patients received preoperative treatment with ineffective histopathological responses. There were two unresectable cases, one was treated with an immune‑checkpoint inhibitor and the other received palliative care. Three of the four patients receiving curative surgery developed hematogenous recurrence within two years of surgery and only one patient with pT1aN0M0 achieved long‑term survival. The median overall survival of all six patients was 19.6 (6.4‑40.5) months. Patients with stage I disease exhibited significantly more favorable prognoses than those with stage II‑IV (P=0.025) and surgically‑treated patients had significantly better prognoses than those who did not receive surgery (P=0.018). In conclusion, PMME was associated with highly malignant features and tended to develop hematogenous metastases even after radical resection. Early diagnosis appears to be important to cure this refractory disease.
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Copy and paste a formatted citation
Spandidos Publications style
Hashimoto T, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Motoori M, Kimura Y, Nakajima K, Nakajima K, et al: Clinicopathological characteristics and survival of primary malignant melanoma of the esophagus. Oncol Lett 18: 1872-1880, 2019.
APA
Hashimoto, T., Makino, T., Yamasaki, M., Tanaka, K., Miyazaki, Y., Takahashi, T. ... Doki, Y. (2019). Clinicopathological characteristics and survival of primary malignant melanoma of the esophagus. Oncology Letters, 18, 1872-1880. https://doi.org/10.3892/ol.2019.10519
MLA
Hashimoto, T., Makino, T., Yamasaki, M., Tanaka, K., Miyazaki, Y., Takahashi, T., Kurokawa, Y., Motoori, M., Kimura, Y., Nakajima, K., Morii, E., Mori, M., Doki, Y."Clinicopathological characteristics and survival of primary malignant melanoma of the esophagus". Oncology Letters 18.2 (2019): 1872-1880.
Chicago
Hashimoto, T., Makino, T., Yamasaki, M., Tanaka, K., Miyazaki, Y., Takahashi, T., Kurokawa, Y., Motoori, M., Kimura, Y., Nakajima, K., Morii, E., Mori, M., Doki, Y."Clinicopathological characteristics and survival of primary malignant melanoma of the esophagus". Oncology Letters 18, no. 2 (2019): 1872-1880. https://doi.org/10.3892/ol.2019.10519
Copy and paste a formatted citation
x
Spandidos Publications style
Hashimoto T, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Motoori M, Kimura Y, Nakajima K, Nakajima K, et al: Clinicopathological characteristics and survival of primary malignant melanoma of the esophagus. Oncol Lett 18: 1872-1880, 2019.
APA
Hashimoto, T., Makino, T., Yamasaki, M., Tanaka, K., Miyazaki, Y., Takahashi, T. ... Doki, Y. (2019). Clinicopathological characteristics and survival of primary malignant melanoma of the esophagus. Oncology Letters, 18, 1872-1880. https://doi.org/10.3892/ol.2019.10519
MLA
Hashimoto, T., Makino, T., Yamasaki, M., Tanaka, K., Miyazaki, Y., Takahashi, T., Kurokawa, Y., Motoori, M., Kimura, Y., Nakajima, K., Morii, E., Mori, M., Doki, Y."Clinicopathological characteristics and survival of primary malignant melanoma of the esophagus". Oncology Letters 18.2 (2019): 1872-1880.
Chicago
Hashimoto, T., Makino, T., Yamasaki, M., Tanaka, K., Miyazaki, Y., Takahashi, T., Kurokawa, Y., Motoori, M., Kimura, Y., Nakajima, K., Morii, E., Mori, M., Doki, Y."Clinicopathological characteristics and survival of primary malignant melanoma of the esophagus". Oncology Letters 18, no. 2 (2019): 1872-1880. https://doi.org/10.3892/ol.2019.10519
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