Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer

  • Authors:
    • Peng Jiang
    • Xiaoting Han
    • Yingnan Zheng
    • Jianchao Sui
    • Weiping Bi
  • View Affiliations

  • Published online on: June 24, 2019     https://doi.org/10.3892/ol.2019.10524
  • Pages: 2109-2117
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Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer‑associated mortality worldwide. The prognosis of patients with CRC at an advanced stage is poor. Biomarkers currently used in clinical practice, including carcinoembryonic antigen (CEA) and cancer antigen (CA) 19‑9, lack sufficient sensitivity and specificity for early diagnosis and prediction, therefore there remains a requirement to improve the prognosis of patients with CRC. Long non‑coding RNAs (lncRNAs) have been revealed to serve fundamental roles in various pathophysiological processes, including cancer initiation and progression. The present study investigated the expression and clinical significance of the lncRNA nuclear factor‑κB interacting long non‑coding RNA (NKILA) in CRC. It was identified that NKILA was downregulated in six CRC cell lines and tissues (n=173). Low NKILA expression was significantly associated with a poor differentiation grade, larger tumor size and advanced Tumor‑Node‑Metastases stages. Further statistical analyses revealed that low NKILA expression predicted poor overall survival (OS) rate and progression‑free survival (PFS) rate. In addition, low NKILA expression was determined as an independent risk factor for poor OS and PFS. Furthermore, NKILA exhibited a relatively high sensitivity and specificity compared with CEA and CA19‑9 in the early diagnosis of CRC. The serum level of NKILA was positively correlated with the level in tissues. In addition, a decreased NKILA level in serum was revealed to be partially restored post‑operatively. In conclusion, low NKILA expression has been demonstrated to accelerate CRC progression and NKILA may be a potential novel biomarker in early diagnosis and prognosis of patients with CRC.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jiang P, Han X, Zheng Y, Sui J and Bi W: Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer. Oncol Lett 18: 2109-2117, 2019.
APA
Jiang, P., Han, X., Zheng, Y., Sui, J., & Bi, W. (2019). Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer. Oncology Letters, 18, 2109-2117. https://doi.org/10.3892/ol.2019.10524
MLA
Jiang, P., Han, X., Zheng, Y., Sui, J., Bi, W."Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer". Oncology Letters 18.2 (2019): 2109-2117.
Chicago
Jiang, P., Han, X., Zheng, Y., Sui, J., Bi, W."Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer". Oncology Letters 18, no. 2 (2019): 2109-2117. https://doi.org/10.3892/ol.2019.10524