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Article

Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer

  • Authors:
    • Peng Jiang
    • Xiaoting Han
    • Yingnan Zheng
    • Jianchao Sui
    • Weiping Bi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Central Hospital of Weihai, Weihai, Shandong 264400, P.R. China, Department of General Surgery, The Central Hospital of Weihai, Weihai, Shandong 264400, P.R. China, Department of Gastroenterology, The Central Hospital of Rizhao, Shandong 276800, P.R. China
  • Pages: 2109-2117
    |
    Published online on: June 24, 2019
       https://doi.org/10.3892/ol.2019.10524
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Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer‑associated mortality worldwide. The prognosis of patients with CRC at an advanced stage is poor. Biomarkers currently used in clinical practice, including carcinoembryonic antigen (CEA) and cancer antigen (CA) 19‑9, lack sufficient sensitivity and specificity for early diagnosis and prediction, therefore there remains a requirement to improve the prognosis of patients with CRC. Long non‑coding RNAs (lncRNAs) have been revealed to serve fundamental roles in various pathophysiological processes, including cancer initiation and progression. The present study investigated the expression and clinical significance of the lncRNA nuclear factor‑κB interacting long non‑coding RNA (NKILA) in CRC. It was identified that NKILA was downregulated in six CRC cell lines and tissues (n=173). Low NKILA expression was significantly associated with a poor differentiation grade, larger tumor size and advanced Tumor‑Node‑Metastases stages. Further statistical analyses revealed that low NKILA expression predicted poor overall survival (OS) rate and progression‑free survival (PFS) rate. In addition, low NKILA expression was determined as an independent risk factor for poor OS and PFS. Furthermore, NKILA exhibited a relatively high sensitivity and specificity compared with CEA and CA19‑9 in the early diagnosis of CRC. The serum level of NKILA was positively correlated with the level in tissues. In addition, a decreased NKILA level in serum was revealed to be partially restored post‑operatively. In conclusion, low NKILA expression has been demonstrated to accelerate CRC progression and NKILA may be a potential novel biomarker in early diagnosis and prognosis of patients with CRC.
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1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Markowitz SD and Bertagnolli MM: Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med. 361:2449–2460. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Sinicrope FA, Okamoto K, Kasi PM and Kawakami H: Molecular biomarkers in the personalized treatment of colorectal cancer. Clin Gastroenterol Hepatol. 14:651–658. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Lipovich L, Johnson R and Lin CY: MacroRNA underdogs in a microRNA world: Evolutionary, regulatory and biomedical significance of mammalian long non-protein-coding RNA. Biochim Biophys Acta. 1799:597–615. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–166. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Mele M and Rinn JL: ‘Cat's cradling’ the 3D genome by the act of LncRNA transcription. Mol Cell. 62:657–664. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Amaral PP, Neyt C, Wilkins SJ, Askarian-Amiri ME, Sunkin SM, Perkins AC and Mattick JS: Complex architecture and regulated expression of the Sox2ot locus during vertebrate development. RNA. 15:2013–2027. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Fu X, Ravindranath L, Tran N, Petrovics G and Srivastava S: Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. DNA Cell Biol. 25:135–141. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Ravasi T, Suzuki H, Pang KC, Katayama S, Furuno M, Okunishi R, Fukuda S, Ru K, Frith MC, Gongora MM, et al: Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res. 16:11–19. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Evans JR, Feng FY and Chinnaiyan AM: The bright side of dark matter: LncRNAs in cancer. J Clin Invest. 126:2775–2782. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Slaby O: Non-coding RNAs as biomarkers for colorectal cancer screening and early detection. Adv Exp Med Biol. 937:153–170. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Li Q, Li N, Lao Y, Lin W, Jiang G, Wei N, Wang C, Liu K and Wu J: Variable levels of long noncoding RNA expression in dna mismatch repair-proficient early-stage colon cancer. Dig Dis Sci. 62:1235–1245. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Sawaki K, Kanda M and Kodera Y: Review of recent efforts to discover biomarkers for early detection, monitoring, prognosis, and prediction of treatment responses of patients with gastric cancer. Expert Rev Gastroenterol Hepatol. 12:657–670. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Lu Q, Yu T, Ou X, Cao D, Xie T and Chen X: Potential lncRNA diagnostic biomarkers for early gastric cancer. Mol Med Rep. 16:9545–9552. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Shang C, Zhu W, Liu T, Wang W, Huang G, Huang J, Zhao P, Zhao Y and Yao S: Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer. Oncol Rep. 35:3185–3197. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Liu B, Sun L, Liu Q, Gong C, Yao Y, Lv X, Lin L, Yao H, Su F, Li D, et al: A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. Cancer Cell. 27:370–381. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Bian D, Gao C, Bao K and Song G: The long non-coding RNA NKILA inhibits the invasion-metastasis cascade of malignant melanoma via the regulation of NF-κB. Am J Cancer Res. 7:28–40. 2017.PubMed/NCBI

19 

Lu Z, Li Y, Wang J, Che Y, Sun S, Huang J, Chen Z and He J: Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway. J Exp Clin Cancer Res. 36:542017. View Article : Google Scholar : PubMed/NCBI

20 

Lu Z, Chen Z, Li Y, Wang J, Zhang Z, Che Y, Huang J, Sun S, Mao S, Lei Y, et al: TGF-β-induced NKILA inhibits ESCC cell migration and invasion through NF-κB/MMP14 signaling. J Mol Med (Berl). 96:301–313. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Yang T, Li S, Liu J, Yin D, Yang X and Tang Q: lncRNA-NKILA/NF-κB feedback loop modulates laryngeal cancer cell proliferation, invasion, and radioresistance. Cancer Med. 7:2048–2063. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Vaiopoulos AG, Athanasoula KCh and Papavassiliou AG: NF-κB in colorectal cancer. J Mol Med (Berl). 91:1029–1037. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Pasparakis M: Role of NF-κB in epithelial biology. Immunol Rev. 246:346–358. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Sunami Y and Wirth T: Intestinal carcinogenesis: IKK can go all the way. J Clin Invest. 121:2551–2553. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Edge SB and Compton CC: The American Joint Committee on Cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Maida M, Macaluso FS, Ianiro G, Mangiola F, Sinagra E, Hold G, Maida C, Cammarota G, Gasbarrini A and Scarpulla G: Screening of colorectal cancer: Present and future. Expert Rev Anticancer Ther. 17:1131–1146. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Kuipers EJ, Grady WM, Lieberman D, Seufferlein T, Sung JJ, Boelens PG, van de Velde CJ and Watanabe T: Colorectal cancer. Nat Rev Dis Primers. 1:150652015. View Article : Google Scholar : PubMed/NCBI

29 

Davies JM and Goldberg RM: Treatment of metastatic colorectal cancer. Semin Oncol. 38:552–560. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Pohl M and Schmiegel W: Colorectal cancer-personalized, stage-adjusted tumour therapy. Dtsch Med Wochenschr. 138:1790–1795. 2013.(In German). PubMed/NCBI

31 

Beretta GD, Milesi L, Pessi MA, Mosconi S and Labianca R: Adjuvant treatment of colorectal cancer. Surg Oncol. 13:63–73. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Nesbitt C, Glendinning RJ, Byrne C and Poston GJ: Factors that influence treatment strategies in advanced colorectal cancer. Eur J Surg Oncol. 33 (Suppl 2):S88–S94. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Nguyen HT and Duong HQ: The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy. Oncol Lett. 16:9–18. 2018.PubMed/NCBI

34 

Heiss JA and Brenner H: Epigenome-wide discovery and evaluation of leukocyte DNA methylation markers for the detection of colorectal cancer in a screening setting. Clin Epigenetics. 9:242017. View Article : Google Scholar : PubMed/NCBI

35 

Vatandoost N, Ghanbari J, Mojaver M, Avan A, Ghayour-Mobarhan M, Nedaeinia R and Salehi R: Early detection of colorectal cancer: From conventional methods to novel biomarkers. J Cancer Res Clin Oncol. 142:341–351. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Link A, Balaguer F, Shen Y, Nagasaka T, Lozano JJ, Boland CR and Goel A: Fecal MicroRNAs as novel biomarkers for colon cancer screening. Cancer Epidemiol Biomarkers Prev. 19:1766–1774. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Pellino G, Gallo G, Pallante P, Capasso R, De Stefano A, Maretto I, Malapelle U, Qiu S, Nikolaou S, Barina A, et al: Noninvasive biomarkers of colorectal cancer: Role in diagnosis and personalised treatment perspectives. Gastroenterol Res Pract. 2018:23978632018. View Article : Google Scholar : PubMed/NCBI

38 

Nikolaou S, Qiu S, Fiorentino F, Rasheed S, Tekkis P and Kontovounisios C: Systematic review of blood diagnostic markers in colorectal cancer. Tech Coloproctol. 22:481–498. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Young GP, Pedersen SK, Mansfield S, Murray DH, Baker RT, Rabbitt P, Byrne S, Bambacas L, Hollington P and Symonds EL: A cross-sectional study comparing a blood test for methylated BCAT1 and IKZF1 tumor-derived DNA with CEA for detection of recurrent colorectal cancer. Cancer Med. 5:2763–2772. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Wu Y, Yang L, Zhao J, Li C, Nie J, Liu F, Zhuo C, Zheng Y, Li B, Wang Z and Xu Y: Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer. Mol Cancer. 14:1912015. View Article : Google Scholar : PubMed/NCBI

41 

Wu W, Chen F, Cui X, Yang L, Chen J, Zhao J, Huang D, Liu J, Yang L, Zeng J, et al: LncRNA NKILA suppresses TGF-β-induced epithelial-mesenchymal transition by blocking NF-κB Signaling in breast cancer. Int J Cancer. 143:2213–2224. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Yu X, Tang W, Yang Y, Tang L, Dai R, Pu B, Feng C and Xia J: Long noncoding RNA NKILA enhances the anti-cancer effects of baicalein in hepatocellular carcinoma via the regulation of NF-κB signaling. Chem Biol Interact. 285:48–58. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang P, Han X, Zheng Y, Sui J and Bi W: Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer. Oncol Lett 18: 2109-2117, 2019.
APA
Jiang, P., Han, X., Zheng, Y., Sui, J., & Bi, W. (2019). Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer. Oncology Letters, 18, 2109-2117. https://doi.org/10.3892/ol.2019.10524
MLA
Jiang, P., Han, X., Zheng, Y., Sui, J., Bi, W."Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer". Oncology Letters 18.2 (2019): 2109-2117.
Chicago
Jiang, P., Han, X., Zheng, Y., Sui, J., Bi, W."Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer". Oncology Letters 18, no. 2 (2019): 2109-2117. https://doi.org/10.3892/ol.2019.10524
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang P, Han X, Zheng Y, Sui J and Bi W: Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer. Oncol Lett 18: 2109-2117, 2019.
APA
Jiang, P., Han, X., Zheng, Y., Sui, J., & Bi, W. (2019). Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer. Oncology Letters, 18, 2109-2117. https://doi.org/10.3892/ol.2019.10524
MLA
Jiang, P., Han, X., Zheng, Y., Sui, J., Bi, W."Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer". Oncology Letters 18.2 (2019): 2109-2117.
Chicago
Jiang, P., Han, X., Zheng, Y., Sui, J., Bi, W."Long non‑coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer". Oncology Letters 18, no. 2 (2019): 2109-2117. https://doi.org/10.3892/ol.2019.10524
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